Compounds for the treatment of metabolic disorders
View Patent ↗Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
1. A compound of the formula:
wherein
n is 1 or 2;
m is 0 or 1;
p is 1 and R 1 is ethyl; or p is 2 and R 1 is hydrogen or ethyl;
one of R 2 and R 3 is methyl, methoxy or perfluoromethyl and the other is hydrogen or methyl;
or when R 1 is hydrogen, a pharmaceutically acceptable salt of the compound.
2. The compound or salt of claim 1 , wherein R 2 is methyl, methoxy or perfluoromethyl and R 3 is hydrogen.
3. The compound or salt of claim 2 , wherein the compound is 4-(4-(2-methyoxybenzyloxy)phenyl)-4-oxobutyric acid.
4. The compound or salt of claim 2 , wherein the compound is 4-(4-(2-methylbenzyloxy)phenyl)-4-oxobutyric acid.
5. The compound or salt of claim 2 , wherein the compound is 4-(3-(2-methylbenzyloxy)phenyl)-4-oxobutyric acid.
6. The compound or salt of claim 2 , wherein the compound is Ethyl 4-(4-(2-methylbenzyloxyl)phenyl)-4-oxobutyrate.
7. The compound or salt of claim 2 , wherein the compound is 4-(4-(2-trifluoromethylbenzyloxy)phenyl)-4-oxobutyric acid.
8. The compound or salt of claim 1 , wherein R 2 is methyl and R 3 is methyl.
9. The compound or salt of claim 8 , wherein the compound is 4-(4-(2,5-dimethylbenzyloxy)phenyl)-4-oxobutyric acid.
10. The compound or salt of claim 8 , wherein the compound is 4-(3-(2,6-dimethylbenzyloxy)phenyl)-4-oxobutyric acid.