Gene and use thereof
View Patent ↗A protein and DNA encoding the same are useful as preventives/remedies for diseases such as hypoglycemia, etc. The protein of the present invention is also useful as a reagent for screening a compound that inhibits the binding of the protein of the present invention to IRAP (insulin responsive aminopeptidase) or to GLUT4 (glucose transporter 4). The compound that inhibits the binding of the protein of the present invention to IRAP or GLUT4 is useful as a preventive/remedy for diseases, e.g., hyperglycemia, diabetes mellitus, etc.
1. An isolated protein containing the amino acid sequence represented by SEQ ID NO: 1 and having an activity of binding to IRAP or GLUT4, or a salt thereof.
2. An isolated protein containing the amino acid sequence represented by SEQ ID NO: 15, or a salt thereof.
3. A pharmaceutical comprising the protein or its salt according to claim 1 or 2 .
4. The pharmaceutical according to claim 3 , which is a preventive/therapeutic agent for hypoglycemia.
5. A method of using the protein or its salt according to claim 1 or 2 , for manufacturing the pharmaceutical comprising the protein or its salt according to claim 1 or 2 .