Quinoline and quinazoline derivatives and drugs containing the same
View Patent ↗There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. The compounds are those represented by formula (I) or pharmacologically acceptable salts or solvates thereof: wherein R 1 and R 2 represent hydrogen, alkyl or the like; R 3 , R 4 , R 5 and R 6 represent hydrogen, halogen, alkyl, alkoxy or the like; R 11 and R 12 represent hydrogen, alkyl, alkylcarbonyl or the like; and A represents any one of formulae (i) to (x), provided that compounds wherein R 3 , R 4 , R 5 and R 6 represent hydrogen and A represents group (v) wherein u is 0 (zero) and R 19 represents phenyl optionally substituted by halogen, alkyl, or alkoxy are excluded.
1. A compound represented by formula (I) or a pharmacologically acceptable salt or solvate thereof:
wherein
X and Z represent —CH
R 1 and R 2 , which may be the same or different, represent a hydrogen atom or C 1-4 alkoxy optionally substituted by a halogen atom;
R 3 , R 4 , R 5 , and R 6 , which may be the same or different, represent a hydrogen atom; a halogen atom; C 1-4 alkyl optionally substituted by a halogen atom; C 1-4 alkoxy optionally substituted by a halogen atom; nitro; amino; or morpholyl;
A represents a group selected from the group consisting of formulae (i) to (vii), wherein R 11 and R 12 , which may be the same or different, represent a hydrogen atom, C 1-4 alkyl optionally substituted by a halogen atom, or C 1-4 alkylcarbonyl optionally substituted by a halogen atom;
provided that compounds wherein R 3 , R 4 , R 5 and R 6 represent a hydrogen atom and A represents group (v) wherein u is 0 (zero) and R 19 represents phenyl optionally substituted by a halogen atom, C 1-4 alkyl, or C 1-4 alkoxy are excluded:
wherein
i is an integer of 1 to 4,
R 13 and R 14 , which may be the same or different, represent a hydrogen atom; C 1-6 alkyl optionally substituted by a halogen atom; or phenyl optionally substituted by a halogen atom or C 1-4 alkyl optionally substituted by a halogen atom,
R 13 and R 14 may form a five- to seven-membered saturated or unsaturated heterocyclic ring optionally containing one or more additional hetero-atoms together with the nitrogen atom to which they are attached, and this heterocyclic ring is optionally substituted by a halogen atom or C 1-4 alkyl optionally substituted by a halogen atom, or, R 13 or R 14 may form C 1-4 alkylene optionally substituted by a halogen atom together with R 12 ;
wherein
j is an integer of 0 to 3,
k is an integer of 0 to 3, provided that
both j and k are not 0 (zero),
m is an integer of 0 to 2,
carbon atoms in the following
are optionally substituted by one or more C 1-4 alkyl groups, which may be the same or different, optionally substituted by a halogen atom, and R 15 represents a hydrogen atom; cyclic C 3-7 alkyl optionally substituted by a halogen atom; phenyl optionally substituted by C 1-6 alkyl or a halogen atom; or C 1-4 alkoxycarbonyl;
wherein
n is 0 (zero) or 1,
p is an integer of 1 to 10, and
R 16 and R 17 , which may be the same or different, represent a hydrogen atom; C 1-6 alkyl optionally substituted by a halogen atom; C 1-4 alkylcarbonyl optionally substituted by a halogen atom; cyclic C 3-7 alkyl optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom; or phenyl optionally substituted by a halogen atom or C 1-4 alkyl optionally substituted by a halogen atom, or
R 16 and R 17 may form a five- to seven-membered saturated or unsaturated heterocyclic ring optionally containing one or more additional hetero-atoms together with the nitrogen atom to which they are attached, this heterocyclic ring is optionally condensed with another one or two carbocyclic or heterocyclic ring to form a ten- to twelve-membered saturated or unsaturated bicyclic carbocyclic ring or heterocyclic ring or a ten- to fifteen-membered saturated or unsaturated tricyclic carbocyclic ring or heterocyclic ring, and these heterocyclic rings are optionally substituted by an oxygen atom or C 1-4 alkyl optionally substituted by a halogen atom;
wherein
q is 0 (zero) or 1,
r is an integer of 0 to 3,
s is an integer of 0 to 3, provided that both
r and s are not 0 (zero),
t is an integer of 0 to 2,
carbon atoms in the following
are optionally substituted by one or more C 1-4 alkyl groups, which may be the same or different, and R 18 represents a hydrogen atom; phenyl optionally substituted by a halogen atom or C 1-6 alkyl optionally substituted by a halogen atom; or C 1-4 alkoxycarbonyl optionally substituted by a halogen atom;
wherein
u is 0 (zero) or 1,
R 19 represents
(1) phenyl which is optionally substituted by C 1-10 alkyl optionally substituted by a halogen atom; C 1-10 alkoxy optionally substituted by a halogen atom; —NR 31 R 32 wherein R 31 and R 32 , which may be the same or different, represent a hydrogen atom or C 1-4 alkyl optionally substituted by a halogen atom; phenyl optionally substituted by a halogen atom; a halogen atom; or cyano,
(2) phenoxy of which the phenyl portion is optionally substituted by C 1-10 alkyl optionally substituted by a halogen atom; C 1-10 alkoxy optionally substituted by a halogen atom; —NR 31 R 32 wherein R 31 and R 32 are as defined above; phenyl optionally substituted by a halogen atom; a halogen atom; or cyano,
(3) cyclic C 3-7 alkyl which is optionally condensed with another carbocyclic ring or heterocyclic ring to form an eight- to twelve-membered bicyclic saturated or unsaturated carbocyclic ring or heterocyclic ring and the carbocyclic ring and the heterocyclic ring are optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom; phenyl optionally substituted by a halogen atom; cyclic C 3-7 alkyl optionally substituted by a halogen atom; or a halogen atom,
(4) a five- to seven-membered saturated or unsaturated heterocyclic ring which is optionally condensed with another carbocyclic or heterocyclic ring to form a ten- to twelve-membered bicyclic saturated or unsaturated heterocyclic ring optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom, or a halogen atom,
wherein
R 20 represents:
(1) phenyl optionally substituted by C 1-6 alkyl optionally substituted by a halogen atom; C 1-6 alkoxy optionally substituted by a halogen atom; —NR 35 R 36 wherein R 35 and R 36 , which may be the same or different, represent a hydrogen atom or C 1-4 alkyl optionally substituted by a halogen atom; phenyl optionally substituted by a halogen atom; a halogen atom; or cyano,
(2) cyclic C 3-7 alkyl which is optionally condensed with another carbocyclic ring or heterocyclic ring to form an eight- to twelve-membered bicyclic saturated or unsaturated carbocyclic ring or heterocyclic ring and the carbocyclic ring and the heterocyclic ring are optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom, or a halogen atom,
(3) a five- to seven-membered saturated or unsaturated heterocyclic ring which is optionally condensed with another carbocyclic ring or heterocyclic ring to form a ten- to twelve-membered bicyclic saturated or unsaturated heterocyclic ring optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom, or a halogen atom,
(4) C 1-20 alkyl,
(5) C 2-6 alkenyl, or
(6) C 2-6 alkynyl, and
wherein (4) C 1-20 alkyl, (5) C 2-6 alkenyl, and (6) C 2-6 alkynyl are optionally substituted by one or more of the following groups:
(a) phenyl optionally substituted by C 1-6 alkyl optionally substituted by a halogen atom; C 1-6 alkoxy optionally substituted by a halogen atom; —NR 35 R 36 wherein R 35 and R 36 are as defined above; phenyl optionally substituted by a halogen atom; a halogen atom; or cyano,
(b) phenoxy of which the phenyl portion is optionally substituted by C 1-6 alkyl optionally substituted by a halogen atom; C 1-6 alkoxy optionally substituted by a halogen atom; —NR 35 R 36 wherein R 35 and R 36 are as defined above; phenyl optionally substituted by a halogen atom; a halogen atom; or cyano,
(c) phenylthio of which the phenyl portion is optionally substituted by C 1-6 alkyl optionally substituted by a halogen atom; C 1-6 alkoxy optionally substituted by a halogen atom; —NR 35 R 36 wherein R 35 and R 36 are as defined above; phenyl optionally substituted by a halogen atom; a halogen atom; or cyano,
(d) —NR 37 R 38 wherein R 37 and R 38 are as defined in R 13 and R 14 ,
(e) cyclic C 3-7 alkyl which is optionally condensed with another carbocyclic ring or heterocyclic ring to form an eight- to twelve-membered bicyclic saturated or unsaturated carbocyclic ring or heterocyclic ring and the carbocyclic ring and the heterocyclic ring are optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom, or a halogen atom,
(f) a five- to seven-membered saturated or unsaturated heterocyclic ring which is optionally condensed with another carbocyclic ring or heterocyclic ring to form a ten- to twelve-membered bicyclic saturated or unsaturated heterocyclic ring optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom, or a halogen atom,
(g) naphthyl, or
(h) cyano;
wherein
v is an integer of 0 to 2,
R 21 represents
(1) phenyl optionally substituted by C 1-6 alkyl optionally substituted by a halogen atom; C 1-6 alkoxy optionally substituted by a halogen atom; ——NR 39 R 40 wherein R 39 and R 40 , which may be the same or different, represent a hydrogen atom or C 1-4 alkyl optionally substituted by a halogen atom; phenyl optionally substituted by a halogen atom; a halogen atom; or cyano,
(2) cyclic C 3-7 alkyl which is optionally condensed with another carbocyclic ring or heterocyclic ring to form an eight- to twelve-membered bicyclic saturated or unsaturated carbocyclic ring or heterocyclic ring and the carbocyclic ring and the heterocyclic ring are optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom, or a halogen atom,
(3) a five- to seven-membered saturated or unsaturated heterocyclic ring which is optionally condensed with another carbocyclic ring or heterocyclic ring to form a ten- to twelve-membered bicyclic saturated or unsaturated heterocyclic ring optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom, or a halogen atom,
(4) C 1-20 alkyl,
(5) C 2-6 alkenyl, or
(6) C 2-6 alkynyl, and
wherein (4) C 1-20 alkyl, (5) C 2-6 alkenyl, and (6) C 2-6 alkynyl are optionally substituted by one or more of the following groups:
(a) phenyl optionally substituted by C 1-6 alkyl optionally substituted by a halogen atom; C 1-6 alkoxy optionally substituted by a halogen atom; —NR 39 R 40 wherein R 39 and R 40 are as defined above; phenyl optionally substituted by a halogen atom; a halogen atom; or cyano,
(b) phenoxy of which the phenyl portion is optionally substituted by C 1-6 alkyl optionally substituted by a halogen atom; C 1-6 alkoxy optionally substituted by a halogen atom; —NR 39 R 40 wherein R 39 and R 40 are as defined above; phenyl optionally substituted by a halogen atom; a halogen atom; or cyano,
(c) phenylthio of which the phenyl portion is optionally substituted by C 1-6 alkyl optionally substituted by a halogen atom; C 1-6 alkoxy optionally substituted by a halogen atom; —NR 39 R 40 wherein R 39 and R 40 are as defined above; phenyl optionally substituted by a halogen atom; a halogen atom; or cyano,
(d) —NR 41 R 42 wherein R 41 and R 42 are as defined in R 13 and R 14 ,
(e) cyclic C 3-7 alkyl which is optionally condensed with another carbocyclic ring or heterocyclic ring to form an eight- to twelve-membered bicyclic saturated or unsaturated carbocyclic ring or heterocyclic ring and the carbocyclic ring and the heterocyclic ring are optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom, or a halogen atom,
f) a five- to seven-membered saturated or unsaturated heterocyclic ring which is optionally condensed with another carbocyclic ring or heterocyclic ring to form a ten- to twelve-membered bicyclic saturated or unsaturated heterocyclic ring optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom, or a halogen atom,
(g) naphthyl, or
(h) cyano.
2. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy and at least one of R 3 , R 4 , R 5 , and R 6 represents a group other than a hydrogen atom.
3. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 represents a group other than a hydrogen atom, and R 4 , R 5 , and R 6 represent a hydrogen atom.
4. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy and A represents group (i) wherein i is an integer of 1 to 3; and R 13 and R 14 , which may be the same or different, represent C 1-4 alkyl, or may form a five- to seven-membered saturated heterocyclic ring optionally substituted by C 1-4 alkyl together with the nitrogen atom to which they are attached.
5. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 , R 4 , R 5 , and R 6 represent a hydrogen atom, and A represents group (i) wherein i is an integer of 1 to 3 and R 13 and R 14 , which may be the same or different, represent C 1-4 alkyl, or may form a five- to seven-membered saturated heterocyclic ring optionally substituted by C 1-4 alkyl together with the nitrogen atom to which they are attached.
6. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 represents a group other than a hydrogen atom, R 4 , R 5 , and R 6 represent a hydrogen atom, and A represents group (i) wherein i is an integer of 1 to 3 and R 13 and R 14 , which may be the same or different, represent C 1-4 alkyl, or may form a five- to seven-membered saturated heterocyclic ring optionally substituted by C 1-4 alkyl together with the nitrogen atom to which they are attached.
7. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 represents nitro, R 4 , R 5 , and R 6 represent a hydrogen atom, and A represents group (i) wherein i is an integer of 1 to 3 and R 13 and R 14 , which may be the same or different, represent C 1-4 alkyl, or may form a five- to seven-membered saturated heterocyclic ring optionally substituted by C 1-4 alkyl together with the nitrogen atom to which they are attached.
8. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy and A represents group (ii) wherein j is 1 or 2, k is 1 or 2, m is 1 or 2, and R 15 represents optionally substituted phenyl.
9. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 , R 4 , R 5 , and R 6 represent a hydrogen atom, and A represents group (ii) wherein j is 1 or 2, k is 1 or 2, m is 1 or 2, and R 15 represents optionally substituted phenyl.
10. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 represents a group other than a hydrogen atom, R 4 , R 5 , and R 6 represent a hydrogen atom, and A represents group (ii) wherein j is 1 or 2, k is 1 or 2, m is 1 or 2, and R 15 represents optionally substituted phenyl.
11. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy and A represents group (iii) wherein n is 0 (zero); p is an integer of 1 to 3; and R 16 and R 17 , which may be the same or different, represent C 1-4 alkyl, or may form a five- to seven-membered saturated heterocyclic ring optionally substituted by C 1-4 alkyl or an oxygen atom together with the nitrogen atom to which they are attached.
12. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 , R 4 , R 5 and R 6 represent a hydrogen atom, and A represents group (iii) wherein n is 0 (zero); p is an integer of 1 to 3; and R 16 and R 17 , which may be the same or different, represent C 1-4 alkyl, or may form a five- to seven-membered saturated heterocyclic ring optionally substituted by C 1-4 alkyl or an oxygen atom together with the nitrogen atom to which they are attached.
13. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 represents a group other than a hydrogen atom, R 4 , R 5 and R 6 represent a hydrogen atom, and A represents group (iii) wherein n is 0 (zero), p is an integer of 1 to 3, and R 16 and R 17 , which may be the same or different, represent C 1-4 alkyl, or may form a five- to seven-membered saturated heterocyclic ring optionally substituted by C 1-4 alkyl or an oxygen atom together with the nitrogen atom to which they are attached.
14. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy and A represents group (iv) wherein q is 0 (zero), r is 1 or 2, s is 1 or 2, t is 1 or 2, and R 18 represents optionally substituted phenyl.
15. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 , R 4 , R 5 and R 6 represent a hydrogen atom, and A represents group (iv) wherein q is 0 (zero), r is 1 or 2, s is 1 or 2, t is 1 or 2, and R 18 represents optionally substituted phenyl.
16. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 represents a group other than a hydrogen atom, R 4 , R 5 , and R 6 represent a hydrogen atom, and A represents group (iv) wherein q is 0 (zero), r is 1 or 2, s is 1 or 2, t is 1 or 2, and R 18 represents optionally substituted phenyl.
17. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy and A represents group (v) wherein u is 1 and R 19 represents optionally substituted phenyl.
18. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 , R 4 , R 5 , and R 6 represent a hydrogen atom, and A represents group (v) wherein u is 1 and R 19 represents optionally substituted phenyl.
19. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 5 represents a group other than a hydrogen atom, R 3 , R 4 , and R 6 represent a hydrogen atom, and A represents group (v) wherein u is 1 and R 19 represents optionally substituted phenyl.
20. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy and A represents group (vi) wherein R 20 represents optionally substituted phenyl, or C 1-6 alkyl optionally substituted by optionally substituted phenyl.
21. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy and A represents group (vii) wherein R 21 represents optionally substituted phenyl, or C 1-6 alkyl optionally substituted by optionally substituted phenyl.
22. The compound according to claim 1 , wherein R 1 and R 2 represent C 1-4 alkoxy, R 3 represents morpholyl, R 4 , R 5 , and R 6 represent a hydrogen atom.
23. The compound of claim 1 , selected from the group consisting of:
(4)1-(3-Chlorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(5) 1-(3-Chlorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(8) 4-FluorobenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(9) 4-FluorobenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(10) 4-FluorobenzylN-{4-[( 6 , 7 -dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(13) 1-(2-Chlorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(14) 1-(2-Chlorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(17) 3-(2-Chlorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(18) 3-(2-Chlorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(21) 4-(Trifluoromethyl)benzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(22) 4-(Trifluoromethyl)benzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(23) 4-(Trifluoromethyl)benzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(26) 3-(2-Chlorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(27) 3-(4-Chlorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(28) 3-(4-Chlorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylpheny}carbamate;
(29) 3-(4-Chlorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(32) 1-(4-Methoxyphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(33) 1-(4-Methoxyphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(34) 1-(4-Methoxyphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(37) 3-[(4-Methylphenyl)sulfanyl)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(38) 3-[(4-Methylphenyl)sulfanyl)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-carbamate;
(39) 3-[(4-Methylphenyl)sulfanyl)propylN-{4-[( 6 , 7 -dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-carbamate;
(42) 3-(4-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(43) 3-(4-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(44) 3-(4-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(47) 3-(3-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(48) 3-(3-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(49) 3-(3-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(52) 1-(3-Methoxyphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(53) 1-(3-Methoxyphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(54) 1-(3-Methoxyphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(57) 4-(Tert-butyl)benzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(58) 4-(Tert-butyl)benzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(59) 4-(Tert-butyl)benzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(62) 3,4-DimethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(63) 3,4-DimethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(64) 3,4-DimethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(67) 2,5-DimethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(68) 2,5-DimethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(69) 2,5-DimethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(72)3-{[4-(Tert-butyl)phenyl]sulfanyl}-propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(73) 3-{[4-(Tert-butyl)phenyl]sulfanyl}propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(74) 3-{[4-(Tert-butyl)phenyl]sulfanyl}propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(77) 3-[(4-Chloro-2-methylphenyl)sulfanyl]-propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-carbamate;
(78) 3-[(4-Chloro-2-methylphenyl)sulfanyl]-propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(79) 3-[(4-Chloro-2-methylphenyl)sulfanyl]-propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(82) 3-(Trifluoromethyl)phenethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(83) 3-(Trifluoromethyl)phenethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-carbamate;
(84) 3-(Trifluoromethyl)phenethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-carbamate;
(87)1-[3-(Trifluoromethyl)phenyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(88) 1-[3-(Trifluoromethyl)phenyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-carbamate;
(89) 1-[3-(Trifluoromethyl)phenyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-carbamate;
(92) 1-(2,4,5-Trifluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(93) 1-(2,4,5-Trifluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-carbamate;
(94) 1-(2,4,5-Trifluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-carbamate;
(97) 1-(3-Fluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(98) 1-(3-Fluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(99) 1-(3-Fluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(102) 1-(4-Fluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(103) 1-(4-Fluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(104) 1-(4-Fluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(107) 4-Methylbenzyl{4-[(6,7-dimethoxy-4-quinolyl)oxy]anilino}methanethioate;
(108) 4-Methylbenzyl{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylanilino}methanethioate;
(109) 4-Methylbenzyl{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylanilino}methanethioate;
(112) 1-(2-Bromophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(113) 1-(2-Bromophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(114) 1-(2-Bromophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(117) 1-(3-Bromophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(118) 1-(3-Bromophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbama;
(119) 1-(3-Bromophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(122) 1-(2-Fluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(123) 1-(2-Fluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(124) 1-(2-Fluorophenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(127) 1-(2-Ethoxyphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(128) 1-(2-Ethoxyphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(129) 1-(2-Ethoxyphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(132) 1-(4-Methylphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(133) 1-(4-Methylphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(134) 1-(4-Methylphenyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(137) 3-[(4-Methylphenyl)sulfanyl]ethylN-{4-[(dimethoxy-4-quinolyl)oxy]-phenyl}carbamate;
(138) 3-[(4-Methylphenyl)sulfanyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(139) 3-[(4-Methylphenyl)sulfanyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(142) 3-(2-Fluorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(143) 3-(2-Fluorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(144) 3-(2-Fluorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(147) 3-(3-Fluorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(148) 3-(3-Fluorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(149) 3-(3-Fluorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(152) 3-(4-Fluorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(153) 3-(4-Fluorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(154) 3-(4-Fluorophenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(157) 3-(2-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(158) 3-(2-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(159) 3-(2-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(161) 3-(3-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(162) 3-(3-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(163) 3-(3-Methoxyphenoxy)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(165) 2-[(2,5-dimethylphenyl)sulfanyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(166) 2-[(2,5-Dimethylphenyl)sulfanyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethyl-phenyl}carbamate;
(167) 2-[(2,5-Dimethylphenyl)sulfanyl]ethylN-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethyl-phenyl}carbamate;
(169)3-[(2,5-Dimethylphenyl)sulfanyl)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(170)3-[(2,5-Dimethylphenyl)sulfanyl]propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethyl-phenyl carbamate;
(171)3-[(2,5-Dimethylphenyl)sulfanyl]propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethyl-phenyl}carbamate;
(173) 3-(2-Pyridylsulfanyl)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-carbamate;
(174) 3-(2-Pyridylsulfanyl)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-carbamate;
(176) 4-Chloro-2-methylphenyl{4-[(6,7-dimethoxy-4-quinolyl)oxy]anilino}methanethioate;
(177) 4-Chloro-2-methylphenyl{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylanilino}methane-thioate;
(178) 4-Chloro-2-methylphenyl{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylanilino}methane-thioate;
(180) 1-[3-(Trifluoromethoxy)phenyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(181) 1-[3-(Trifluoromethoxy)phenyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-carbamate;
(182) 1-[3-(Tnfluoromethoxy)phenyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(184) 1-PhenylbutylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(185) 1-PhenylbutylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(186) 1-PhenylbutylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(188) 2-(Dimethylamino)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(189) 2-(Dimethylamino)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(190) 2-(Dimethylamino)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(192) 4-(Dimethylamino)butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(193) 4-(Dimethylamino)butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(195) 2-Methyl-1-phenylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(196) 2-Methyl-1-phenylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(197) 2-Methyl-1-phenylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(199) 1-[3-(Dimethylamino)phenyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(200) 1-[3-(Dimethylamino)phenyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-carbamate;
(201) 1-[3-(Dimethylamino)phenyl]ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(203) 2-(2-Fluorophenoxy)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(204) 2-(2-Fluorophenoxy)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(205) 2-(2-Fluorophenoxy)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(207) 2-(3-Fluorophenoxy)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(208) 2-(3-Fluorophenoxy)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(209) 2-(3-Fluorophenoxy)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(214) 3-MethoxyphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(215) PropylN-{4-[(6,7-Dimethoxy-4-quinolin)oxy]-2,3-dimethylphenyl}carbamate;
(216) PhenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(217) PhenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(218) BenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(219) BenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(221) CyclohexylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(222) CyclohexylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(223) 2-MethylphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(224) PhenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(226) 3-MethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(227) 2-ChlorobenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(228) 3-ChlorobenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(229) 4-ChlorobenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(230) CyclohexylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(231) BenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(232) 2-MethylbenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(233) 3-MethylbenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(234) 4-MethylbenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(235) 2-ChlorobenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(236) 3-ChlorobenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(237) 4-ChlorobenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(238) 3-MethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(239) 2-MethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(240) 3-MethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(241) 2-ChlorobenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(242) 3-ChlorobenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(243) 4-ChlorobenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(244) PropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(245) 2-MethylbenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(246) 2-NaphthylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(247) PropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(248) 2-MethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(249) 4-MethoxybenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(250) 2-MethylbenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(251) 3-MethylbenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(252) 4-MethylbenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(253) 2-MethylbenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(254) 3-MethylbenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(255) 4-MethylbenzylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(256) HexylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(257) 4-ButylphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(258) 1-EthylbutylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(259) 4-(Tert-butyl)phenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(260) 2-MethoxyphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(261) HexylN-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(262) HexylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(263) 1-PhenylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(264) 1-PhenylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(265) 1-PhenylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(266) 4-PentenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(267) 4-PentenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(268) 4-PentenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(269)2,6-DimethylphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(270) 2,6-DimethylphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(271) 2,6-DimethylphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(272) 4-ButylphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(273) 4-ButylphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(274) 4-(Tert-butyl)phenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(275) 4-(Tert-butyl)phenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(276) 1-EthylbutylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(277) 1-EthylbutylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(278) 2-MethoxyphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(279) 2-MethoxyphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(280) 2,6-DimethoxyphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(281) 2,6-DimethoxyphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(282) 2,6-DimethoxyphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(283) CyclohexylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(284) CyclohexylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(285) CyclohexylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(286) CycloheptylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(287) CycloheptylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(288) CycloheptylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(289) 2-MethylphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(290) 3-MethoxyphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(291) 3-MethoxyphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(292) 1,2,3,4-Tetrahydro-2-naphthalenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(293) 1,2,3,4-Tetrahydro-2-naphthalenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(294) 4-PhenylphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(295) 4-PhenylphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(296) 4-PhenylphenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(297) PhenethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(298) PhenethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(299) PhenethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(300) 2-(Tert-butyl)phenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(301) 2-(Tert-butyl)phenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(302) 2-(Tert-butyl)phenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(303) 2-PiperidinoethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(304) 2-PiperidinoethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(305) 2-PiperidinoethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(306) 2-MorpholinoethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(307) 2-MorpholinoethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(308) 2-MorpholinoethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(309) 6-(Dimethylamino)hexylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(310) 6-(Dimethylamino)hexylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(311) 6-(Dimethylamino)hexylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(321) ButylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(322) ButylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(323) ButylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(324) IsopropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(325) IsopropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(326) OctadecylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(327) OctadecylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(328) OctadecylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(329) 1-EthylpentylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(330) 1-EthylpentylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(331) 1-EthylpentylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(332) 1-PropylbutylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(333) 1-PropylbutylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(334) 1-PropylbutylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(347) IsopropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(348) CycloheptylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(349) CycloheptylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(350) CycloheptylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(353) 2-CyclohexylethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(354) 2-CyclohexylethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(355) 2-CyclohexylethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(358) 1-EthylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(359) 1-EthylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(360) 1-EthylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(363) CyclopentylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(364) CyclopentylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(365) CyclopentylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(368) 1-ButylpentylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(369) 1-ButylpentylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(370) 1-ButylpentylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(373) AllylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(374) AllylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(376) 3-PhenylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(377) 3-PhenylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(378) 3-PhenylpropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(380) CyclopropylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(381) CyclopropylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(382) CyclopropylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(385) CyclobutylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(386) CyclobutylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(387) CyclobutylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(394) CyclopentylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(395) CyclopentylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(396) CyclopentylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(404) 2-MethylallylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(405) 2-MethylallylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(406) 2-MethylallylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(408) 1-Ethyl-3-butynylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(409) 1-Ethyl-3-butynylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(410) 1-Ethyl-3-butynylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(411) 1-MethylhexylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(412) 1-MethylhexylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(413) 1-MethylhexylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(414) 3-PiperidinopropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(415) 3-PiperidinopropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(416) 1,3-Dioxo-2,3-dihydro-1H-2-isoindolylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(417) (1,3-Dioxo-2,3-dihydro-1H-2-isoindolyl)methylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy-2,5-dimethylphenyl}carbamate;
(418) (1,3-Dioxo-2,3-dihydro-1H-2-isoindolyl)methylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy-2,3-dimethylphenyl}carbamate;
(419) 2-(1,3-Dioxo-2,3-dihydro-1H-2-isoindolyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy-2,5-dimethylphenyl}carbamate;
(420) 2-(1,3-Dioxo-2,3-dihydro-1H-2-isoindolyl)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy-2,3-dimethylphenyl}carbamate;
(421) 3-MorpholinopropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(422) 3-MorpholinopropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(423) 3-MorpholinopropylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(424) 3-(4-Methylpiperazino)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(425) 3-(4-Methylpiperazino)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate
(426) 3-(Diethylamino)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(427) 3-(Diethylamino)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(428) 3-(Diethylamino)propylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(430) 2-PyridylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(431) 2-PyridylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(432) 3-PyridylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(433) 4-PyridylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(435) 2-(Diethylamino)ethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(437) 1-(2-Morpholinoethyl)butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(438) 1-(2-Morpholinoethyl)butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphey}carbamate;
(439) 1-(2-Morpholinoethyl)butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphey}carbamate;
(441) 1-[2-(Diethylamino)ethyl]butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(442) 1-[2-(Diethylamino)ethyl]butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(443) 1-[2-(Diethylamino)ethyl]butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(445) 1-(2-Piperidinoethyl)butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(446) 1-(2-Piperidinoethyl)butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(447) 1-(2-Piperidinoethyl)butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(449) 1-[2-(4-Methylpiperazino)ethyl]butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(450) 1-[2-(4-Methylpiperazino)ethyl]butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethyl-phenyl}carbamate;
(451) 1-[2-(4-Methylpiperazino)ethyl]butylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethyl-phenyl}carbamate;
(453) Cyano(phenyl)methylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(454) Cyano(phenyl)methylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(455) Cyano(phenyl)methylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(457) 3-CyanophenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(458) 3-CyanophenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(459) 3-CyanophenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(460) 4-CyanophenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(461) 4-CyanophenylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(462) 1-Methyl-3-piperidylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(463) 1-Methyl-3-piperidylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(464) 1-Methyl-3-piperidylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(466) 1-Methyl-4-piperidylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(467) 1-Methyl-4-piperidylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(468) 1-Methyl-4-piperidylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(470) Tetrahydro-2H-4-pyranylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}carbamate;
(471) Tetrahydro-2H-4-pyranylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}carbamate;
(472) Tetrahydro-2H-4-pyranylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}carbamate;
(483) CycloheptylmethylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}N-methylcarbamate;
(496) 1-Ethyl-3-butynylN-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}N-methylcarbamate;
(511) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(2-diethylaminoethyl)thiourea;
(512) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(2-piperidinylethyl)thiourea;
(513) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-[4-(N-benzyl)piperidinyl]thiourea;
(514) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-(2-piperidinylethyl)thiourea;
(515) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-(2-acetamidoethyl)thiourea;
(520) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(N-cyclohexylamino)thiourea;
(521) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(1-piperidinyl)thiourea;
(522) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-(1-piperidinyl)thiourea;
(523) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-(N -cyclohexylamino)thiourea;
(538) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-(2-dimethylaminoethyl)thiourea;
(539) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-[3-(1-imidazoyl)propyl]thiourea;
(540) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-{2-[N-ethyl-N-(o-tolyl)amino]-ethyl}thiourea;
(541) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-[2-(1-pyrrolidinyl)ethyl]thiourea;
(542) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(2-dimethylaminoethyl)thiourea;
(543) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-[3-(1-imidazoyl)propyl]thiourea;
(544) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-{2-[N-ethyl-N-(o -tolyl)amino]-ethyl}thiourea;
(545) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-[2-(1-morpholino)ethyl]thiourea;
(546) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(3-diethylaminopropyl)thiourea;
(547) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(3-dibutylaminopropyl)thiourea;
(548) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-[3-(1-morpholino)propyl]thiourea;
(549) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-[3-(2-methylpiperidinyl)propyl]-thiourea;
(550) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(2-diisopropylaminoethyl)thiourea;
(551) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-(3-diethylaminopropyl)thiourea;
(552) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-(3-dibutylaminopropyl)thiourea;
(553) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-[3-(1-morpholino)propyl]thiourea;
(554) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-[3-(2-methylpiperidinyl)propyl]-thiourea;
(555) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-(2-diisopropylaminoethyl)thiourea;
(556) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-[3-(4-methylpiperazinyl)propyl]-thiourea;
(557) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-[3-(4-methylpiperazinyl)propyl]-thiourea;
(558)-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-[3-(1-piperidinyl)propyl]thiourea;
(560) N-(1-Benzyltetrahydro-1H-3-pyrrolyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea;
(561) Ethyl4-[({4-[(6,7-dimethoxy-4-quinolyl)oxy]anilino}carbonyl)amino]-1-piperidine-carboxylate;
(562) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2,2,6,6-tetramethyl-4-piperidyl)urea;
(564) N-[(3R)-1-Benzyltetrahydro-1H-3-pyrrolyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea;
(565) N-[(3S)-1-Benzyltetrahydro-1H-3-pyrrolyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-urea;
(568) N-{4-[(6,7-Dimethoxy-4-quinolyl)-oxy]phenyl}-N′-[1-(2-methylbenzyl)-4-piperidyl]urea;
(572) N-{4-[(6,7-Dimethoxy-4-puinolyl)oxy]-2,3-dimethylphenyl}-N′-[1-(2-methylbenzyl)tetrahydro-1H-3-pyrrolyl]urea;
(574) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-[1-(2-methylbenzyl)tetrahydro-1H-3-pyrrolyl]-urea;
(579) N-[1-(2-Chlorobenzyl)tetrahydro-1H-3-pyrrolyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-urea;
(582) N-{1-[4-(Tert-butyl)benzyl]tetrahydro-1H-3-pyrrolyl}-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-phenyl}urea;
(585) N-[1-(Cyclohexylmethyl)tetrahydro-1H-3-pyrrolyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-phenyl}urea;
(588) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2-diethylaminopropyl)thiourea;
(589) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2-diethylaminoethyl)thiourea;
(590) N-{4-[(6,7-Dimethoxy-4-quinolyl)-oxy]phenyl}-N′-[4-(N-benzyl)piperidinyl]urea;
(604) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-[4-(N-benzyl)piperidinyl]urea;
(605) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-chlorophenyl}-N′-[4-(N-benzyl)piperidinyl]urea;
(607) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methoxyphenyl}-N′-[4-(N-benzyl)piperidinyl]urea;
(614) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2-methylbenzoyl)thiourea;
(616) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-(2-morpholinoethyl)urea;
(617) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(2-morpholinoethyl)urea;
(618) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2-tetrahydro-1H-1-pyrrolylethyl)urea;
(619) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-(2-tetrahydro-1H-1-pyrrolyl-ethyl)urea;
(620) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(2-tetrahydro-1H-1-pyrrolyl-ethyl)urea;
(622) N-[2-(Diethylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea;
(623) N-[2-(Diethylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}urea;
(624) N-[2-(Diethylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}urea;
(625) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-[2-(dimethylamino)ethyl]urea;
(626) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-[2-(dimethylamino)ethyl]urea;
(634) N-(1-Benzyl-4-piperidyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}urea;
(635) N-(1-Benzyl-4-piperidyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}urea;
(638) N-(1-Benzyl-4-piperidyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-nitrophenyl}urea;
(639) N-(1-Benzyl-4-piperidyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}urea;
(642) N-(1-Benzyl-4-piperidyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-methylphenyl}urea;
(643) N-(1-Benzyl-4-piperidyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-methylphenyl}urea;
(644) N-(1-Benzyl-4-piperidyl)-N′-{3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea;
(646) N-[2-(Diethylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-nitrophenyl}urea;
(648) N-[2-(Diethylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-methylphenyl}urea;
(649) N-[2-(Diethylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-methylphenyl}urea;
(650) N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[2-(diethylamino)ethyl]urea;
(651) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[2-(diethylamino)ethyl]urea;
(654) N-[2-(Diisopropylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea;
(655) N-[2-(Diisopropylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}urea;
(658) N-[2-(Diisopropylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-nitrophenyl}urea;
(661) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]phenyl}-N′-[2-(ethyl-3-methylanilino) -ethyl]urea;
(662) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-[2-(ethyl-3-methylanilino)ethyl]-urea;
(663) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-[2-(ethyl-3-methylanilino)ethyl]-urea;
(666) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-nitrophenyl}-N′-[2-(ethyl-3-methylanilino)ethyl]urea;
(669) N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[2-(ethyl-3-methylanilino)-ethyl]urea;
(670) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methoxyphenyl}-N′-[2-(ethyl-3-methylanilino)ethyl]urea;
(671) N-[2-(Diisopropylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}urea;
(672) N-[2-(Diisopropylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-methoxyphenyl}urea;
(673) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2-piperidinoethyl)urea;
(674) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-(2-piperidinoethyl)urea;
(675) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(2-piperidinoethyl)urea;
(678) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-nitrophenyl}-N′-(2-piperidinoethyl)urea;
(681) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methoxyphenyl}-N′-(2-piperidinoethyl)urea;
(682) N-[2-(Dibutylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}urea;
(683) N-[2-(Dibutylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}urea;
(684) N-[2-(Dibutylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}urea;
(689) N-[2-(Dibutylamino)ethyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-methoxyphenyl}urea; and
(692) N-[(5-Bromo-2-thienyl)carbonyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-methylphenyl}thiourea;
(693) N-[(5-Bromo-2-thienyl)carbonyl]-N′-{3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(694) N-[(5-Chloro-2-thienyl)carbonyl]-N′-{4[(6,7-dimethoxy-4-quinolyl)oxy]-2-methylphenyl}thio-urea;
(695) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(5-chloro-2-thienyl)carbonyl]-thiourea;
(698) N-{4-[(6,7-Dimethoxy-4-quinolyl)-oxy]-2-methylphenyl}-N′-[(2,5-dimethyl-3-furyl)-carbonyl]thiourea;
(699) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(2,5-dimethyl-3-furyl)-carbonyl]thiourea;
(706) N-Benzyl-N′-{3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea
(717) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N′-[(2,5-dimethyl-3-furyl)carbonyl]-thiourea;
(749) N-[(2,2-Dichloro-1-methylcyclopropyl)-carbonyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(750) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(2,2-dichloro-1-methylcyclo-propyl)carbonyl]thiourea;
(751) N-(4-Butoxybenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(752) N-(4-Butoxybenzoyl)-N′-{3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(753) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-[4-(pentyloxy)benzoyl]thiourea;
(754) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[4-(pentyloxy)benzoyl]thiourea;
(755) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-[4-(hexyloxy)benzoyl]thiourea;
(756) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-N′-[4-(hexyloxy)benzoyl]thiourea;
(759) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2,2,3,3-tetramethylcyclopropyl)carbonyl ]-thiourea;
(760) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(2,2,3,3-tetramethylcyclo-propyl)carbonyl]thiourea;
(765) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-tetrahydro-2-furanylcarbonylthiourea;
(766) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-tetrahydro-2-furanylcarbonyl-thiourea;
(767) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-[(3-methoxycyclohexyl)carbonyl]thiourea;
(768) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(3-methoxycyclohexyl)carbonyl]-thiourea;
(897) N-Benzoyl-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(898) N-(2-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(899) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2-fluorobenzoyl)thiourea;
(900) N-(2-Bromobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(901) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2-methoxybenzoyl)thiourea;
(902) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-[2-(trifluoromethyl)benzoyl]thiourea;
(903) N-Benzoyl-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(904) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(2-methylbenzoyl)thiourea;
(905) N-(2-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(906) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(2-fluorobenzoyl)thiourea;
(907) N-(2-Bromobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(908) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(2-iodobenzoyl)thiourea;
(909) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(2-methoxybenzoyl)thiourea;
(910) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-[2-(trifluoromethyl)benzoyl]thiourea;
(911) N-Benzoyl-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(912) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(2-methylbenzoyl)thiourea;
(913) N-(2-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(914) N-(2-Bromobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(915) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(2-iodobenzoyl)thiourea;
(916) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(2-methoxybenzoyl)thiourea;
(917) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-[2-(trifluoromethyl) benzoyl]thiourea;
(918) N-Benzoyl-N′-{3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(919) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2-methylbenzoyl)thiourea;
(921) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2-fluorobenzoyl)thiourea;
(922) N-(2-Bromobenzoyl)-N′-{3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(923) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2-methoxybenzoyl)thiourea;
(924) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[2-(trifluoromethyl)benzoyl}thiourea;
(925) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-nitrophenyl}-N′-(2-methylbenzoyl)thiourea;
(930) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(3-methylbenzoyl)thiourea;
(931) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(3-fluorobenzoyl)thiourea;
(932) N-(3-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(933) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(3-methoxybenzoyl)thiourea;
(934) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-[3-(trifluoromethyl)benzoyl]thiourea;
(935) N-(3-Bromobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(936) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(3-methylbenzoyl)thiourea;
(937) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(3-fluorobenzoyl)thiourea;
(938) N-(3-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(939) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(3-methoxybenzoyl)thiourea;
(940) N-(3-Bromobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(941) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(3-methylbenzoyl)thiourea;
(942) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(3-fluorobenzoyl)thiourea;
(943) N-(3-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(944) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(3-methoxybenzoyl)thiourea;
(945) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-[3-(trifluoromethyl)benzoyl]thiourea;
(946) N-(3-Bromobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(947) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(3-methylbenzoyl)thiourea;
(948) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(3-fluorobenzoyl)thiourea;
(949) N-(3-Chlorobenzoyl)-N′-[3-chloro-4-(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(950) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(3-methoxybenzoyl)thiourea;
(951) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[3-(trifluoromethyl)benzoyl]-thiourea;
(952) N-(3-Bromobenzoyl)-N′-{3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(953) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-nitrophenyl}-N′-(3-methylbenzoyl)thiourea;
(959) N-{4-[(6,7-Dimethoxy-4-quinolyl)-oxy]phenyl}-N′-(4-methylbenzoyl)thiourea;
(960) N-(4-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(961) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(4-fluorobenzoyl)thiourea;
(962) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(4-nitrobenzoyl)thiourea;
(963) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(4-methoxybenzoyl)thiourea;
(964) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(4-methylbenzoyl)thiourea;
(965) N-(4-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(966) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(4-fluorobenzoyl)thiourea;
(967) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(4-iodobenzoyl)thiourea;
(968) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(4-nitrobenzoyl)thiourea;
(969) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(4-methoxybenzoyl)thiourea;
(970) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(4-methylbenzoyl)thiourea;
(971) N-(4-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(972) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(4-fluorobenzoyl)thiourea;
(973) N-(4-Bromobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(974) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(4-iodobenzoyl)thiourea;
(975) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(4-nitrobenzoyl)thiourea;
(976) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(4-methoxybenzoyl)thiourea;
(977) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(4-methylbenzoyl)thiourea;
(978) N-(4-Chlorobenzoyl)-N′-[3-chloro-4-(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(979) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(4-fluorobenzoyl)thiourea;
(980) N-(4-Bromobenzoyl)-N′-{3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(981) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(4-iodobenzoyl)thiourea;
(982) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(4-nitrobenzoyl)thiourea;
(983) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(4-methoxybenzoyl)thiourea;
(989) N-(1,3-Benzodioxol-5-ylcarbonyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(990) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(4-ethoxybenzoyl)thiourea;
(991) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(4-phenylbenzoyl)thiourea;
(992) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(4-ethoxybenzoyl)thiourea;
(993) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluoropheny}-N′-(4-ethylbenzoyl)thiourea;
(994) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(4-propylbenzoyl)thiourea;
(995) N-(4-Butylbenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(996) N-[4-(Chloromethyl)benzoyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(997) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(4-ethylbenzoyl)thiourea;
(998) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(4-propylbenzoyl)thiourea;
(999) N-(4-Butylbenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(1000) N-[4-(Chloromethyl)benzoyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(1001) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(4-propylbenzoyl)thiourea;
(1003) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2,4-dimethylbenzoyl)thiourea;
(1004) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2,5-dimethylbenzoyl)thiourea;
(1005) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2,3-dimethylbenzoyl)thiourea;
(1006) N-(2,4-Difluorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1007) N-(2,6-Difluorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1008) N-(2,4-Dichlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1009) N-(3,5-Dichlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1010) N-(3,4-Dimethoxybenzoyl)-N′-{4-[(6,-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1011) N-(2,4-Dichlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(1012) N-(2,6-Dichlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(1013) N-(2,4-Difluorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(1014) N-(2,4-Dichlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(1015) N-(3,5-Dichlorobenzoyl)-N′-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(1016) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2,4-dimethylbenzoyl)thiourea;
(1017) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2,5-dimethylbenzoyl)thiourea;
(1018) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2,3-dimethylbenzoyl)thiourea;
(1019) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(3,5-dimethylbenzoyl)thiourea;
(1020) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2,6-difluorobenzoyl)thiourea;
(1033) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(2-furylcarbonyl)thiourea;
(1034) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(3-thienylcarbonyl)thiourea;
(1035) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(2-furylcarbonyl)thiourea;
(1036) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-(3-thienylcarbonyl)thiourea;
(1037) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-[(2,5-dimethyl-3-furyl)carbonyl]-thiourea;
(1038) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}-N′-[(3-methyl-2-thienyl)carbonyl]thio-urea;
(1039) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-[(2,5-dimethyl-3-furyl)carbonyl]thio-urea;
(1040) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-[(5-methyl-2-thienyl)carbonyl]thio-urea;
(1044) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-tetrahydro- 1H-1-pyrrolylcarbonylthiourea;
(1045) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-morpholinocarbonylthiourea;
(1051) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-tetrahydro-1H-1-pyrrolyl-carbonylthiourea;
(1052) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-morpholinocarbonylthiourea;
(1055) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-[(2-phenylcyclopropyl)carbonyl]thiourea;
(1056) N-Cyclopropylcarbonyl-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(1057) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-[(2-phenylcyclopropyl)carbonyl]thio-urea;
(1058) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-cyclopropylcarbonylthiourea;
(1059) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(2-phenylcyclopropyl)carbonyl]-thiourea;
(1061) N-Cyclopentylcarbonyl-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1062) N-Cyclohexylcarbonyl-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1063) N-Cyclopentylcarbonyl-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(1064) N-Cyclohexylcarbonyl-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(1070) N-(3,4-Dimethoxybenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(1078) N-(2-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}thiourea;
(1079) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(3-methylbenzoyl)thiourea;
(1080) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(4-methylbenzoyl)thiourea;
(1081) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(4-nitrobenzoyl)thiourea;
(1082) N-(4-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}thiourea;
(1083) N-(3-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}thiourea;
(1084) N-Benzoyl-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}thiourea;
(1085) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(2-methylbenzoyl)thiourea;
(1086) N-(2,4-Dichlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-22-dimethylphenyl}thiourea;
(1087) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N′-(4-methoxybenzoyl)thiourea;
(1088) N-(2,4-Difluorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}thiourea;
(1089) N-(4-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-methylphenyl}thiourea;
(1090) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methylphenyl}-N′-(2-methylbenzoyl)thiourea;
(1091) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methylphenyl}-N′-(3-fluorobenzoyl)thiourea;
(1092) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methylphenyl}-N′-(4-nitrobenzoyl)thiourea;
(1093) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methylphenyl}-N′-(4-fluorobenzoyl)thiourea;
(1094) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methylphenyl}-N′-(2-fluorobenzoyl)thiourea;
(1095) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methylphenyl}-N′-(4-methoxybenzoyl)thiourea;
(1096) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methylphenyl}-N′-(4-methylbenzoyl)thiourea;
(1097) N-(2-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-methylphenyl}thiourea;
(1098) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2-methylphenyl}-N′-(3-methylbenzoyl)thiourea;
(1099) N-Benzoyl-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-methylphenyl}thiourea;
(1100) N-(3-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-methylphenyl}thiourea;
(1101) N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2-methylbenzoyl)thiourea;
(1102) N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(4-methylbenzoyl)thiourea;
(1103) N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2-methoxybenzoyl)thiourea;
(1104) N-(2-Chlorobenzoyl)-N′-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1107) N-Benzoyl-N′-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1108) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-methylphenyl}-N′-(4-nitrobenzoyl)thiourea;
(1109) N-Benzoyl-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-methylphenyl}thiourea;
(1110) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-methylphenyl}-N′-(3-methylbenzoyl)thiourea;
(1111) N-(4-Chlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-methylphenyl}thiourea;
(1112) N-(2,6-Dichlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(1113) N-(2,4-Dimethoxybenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}thiourea;
(1114) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2,4-dichlorobenzoyl)thiourea;
(1115) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2,6-dichlorobenzoyl)thiourea;
(1116) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(3,5-dichlorobenzoyl)thiourea;
(1117) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2,4-dimethoxybenzoyl)thiourea;
(1118) N-(2,6-Dichlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1119) N-(2,4-Dimethoxybenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1120) N-(3,4-Dichlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1121) N-(2,4-Difluorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(1122) N-(3,5-Dichlorobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(1123) N-(2,4-Dimethoxybenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(1124) N-(4-Cyclohexylbenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1125) N-(4-Phenylbenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2-fluorophenyl}thiourea;
(1126) N-(1,3-Benzodioxol-5-ylcarbonyl)-N′-{3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thio-urea;
(1127) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(4-cyclohexylbenzoyl)thiourea;
(1128) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(4-octylbenzoyl)thiourea;
(1129) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(3,5-dimethylbenzoyl)thiourea;
(1130) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(1,2,3,4-tetrahydro-2-isoquinolylcarbonyl)-thiourea;
(1136) N-[4-(Chloromethyl)benzoyl]-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1137) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[4-(chloromethyl)benzoyl]thio-urea;
(1143) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}N-ethyl-N′-[(2-phenylcyclopropyl)carbonyl]thio-urea;
(1146) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-[(5-methyl-2-thienyl)carbonyl]thiourea;
(1152) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-(3-pyridylcarbonyl)thiourea;
(1153) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N′-[4-(morpholinomethyl)benzoyl]thiourea; (1159) N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(3,5-dichlorobenzoyl)thiourea;
(1160) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-fluorophenyl}-N′-(2-fluorobenzoyl)thiourea;
(1163) N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(3-fluorobenzoyl)thiourea;
(1165) N-(3-Bromobenzoyl)-N′-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1166) N-(4-Bromobenzoyl)-N′-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1167) N-(4-Bromobenzoyl)-N′-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1173) N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(4-methoxybenzoyl)thiourea;
(1174) N-(4-Chlorobenzoyl)-N′-{2-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}thiourea;
(1176) N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2,4dimethoxybenzoyl)thiourea;
(1179) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-cyclohexylcarbonylthiourea;
(1182) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-cyclopentylcarbonylthiourea;
(1190) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(2-methylcyclopropyl)carbonyl]thiourea;
(1192) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(1-methylcyclohexyl)carbonyl]-thiourea;
(1194) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(1-phenylcyclopropyl)carbonyl]-thiourea;
(1196) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-[(4-propylcyclohexyl)carbonyl]-thiourea;
(1202) N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2,4-difluorobenzoyl)thiourea;
(1204) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(3,4-dimethoxybenzoyl)thiourea;
(1208) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(2,4-difluorobenzoyl)thiourea; and
(1209) N-{3-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N′-(4-octylbenzoyl)thiourea.
24. A compound represented by formula (I) or a pharmacologically acceptable salt or solvate thereof:
wherein
X and Z represent —CH;
R 1 and R 2 represent C 1-4 alkoxy;
R 3 , R 4 , R 5 , and R 6 , which may be the same or different, represent a hydrogen atom; a halogen atom; C 1-4 alkyl optionally substituted by a halogen atom; C 1-4 alkoxy optionally substituted by a halogen atom; nitro; amino; or morpholyl; and
A represents group (viii):
wherein
w is an integer of 1 to 4,
L represents —O—, —S(═O) y —, wherein y is an integer of 0 to 2, or —N(—R 11 )—,
M represents —O—, —C(═O)—O—, —S(═O) z —, wherein z is an integer of 0 to 2, —N(—R 12 ) —, —C(═O)—N(—R 12 )—, or —C(═O)—,
R 11 and R 12 , which may be the same or different, represent a hydrogen atom, C 1-4 alkyl optionally substituted by a halogen atom, or C 1-4 alkylcarbonyl optionally substituted by a halogen atom;
R 22 represents a hydrogen atom; C 1-4 alkyl optionally substituted by a halogen atom; or phenyl optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom, C 1-4 alkoxy optionally substituted by a halogen atom, nitro, amino, or a halogen atom,
when M represents —N(—R )— or —C(═O)—N(—R 12 )—, R 22 and R 12 may form a five- to seven-membered saturated or unsaturated heterocyclic ring optionally containing one or more additional hetero-atoms together with the nitrogen atom to which they are attached, this heterocyclic ring is optionally condensed with another carbocyclic ring or heterocyclic ring to form a ten- to twelve-membered bicyclic saturated or unsaturated heterocyclic ring, and these heterocyclic rings are optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom; phenyl; benzyl; or piperidine;
wherein, when L represents —O—, then M represents —O—, —C(═O)—O—, —N(—R 12 )—, —C(═O)—N(R 12 )—, or —C(═O)—; when L represents —S(═O)—, M represents —O—; and, when L represents —N(—R 11 )—, then M represents —O—.
25. The compound of claim 25 , which is selected from the group consisting of:
(776) N1-(2-Methoxyphenyl)-2-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenoxy}acetamide;
(777) N-(2-{4-[(6,7-Dimethoxy-4-quinolyl)-oxy]phenoxy}ethyl)-N-(2-methoxyphenyl)amine;
(778) N1-(3-Methoxyphenyl)-2-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenoxy}acetamide;
(779) N-(2-{4-[(6,7-Dimethoxy-4-quinolyl)-oxy]phenoxy}ethyl)-N-(3-methoxyphenyl)amine;
(780) N1-(4-Methoxyphenyl)-2-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenoxy}acetamide;
(781) N-(2-{4-[(6,7-Dimethoxy-4-quinolyl)-oxy]phenoxy}ethyl)-N-(4-methoxyphenyl)amine;
(782) N1-(2-Methylphenyl)-2-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenoxy}acetamide;
(783) N-(2-{4-[(6,7-Dimethoxy-4-quinolyl)-oxy]phenoxy}ethyl)-N-(2-methylphenyl)amine;
(784) N1-(3-Methylphenyl)-2-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenoxy}acetamide;
(785) N-(2-{4-[(6,7-Dimethoxy-4-quinolyl)-oxy]phenoxy}ethyl)-N-(3-methylphenyl)amine;
(786) N1-(4-Methylphenyl)-2-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenoxy}acetamide;
(787) N-(2-{4-[(6,7-Dimethoxy-4-quinolyl)-oxy]phenoxy}ethyl)-N-(4-methylphenyl)amine;
(788) N1-(3-Chlorophenyl)-2-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenoxy}acetamide;
(789) N1-(4-Chlorophenyl)-2-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenoxy}acetamide;
(790) 6,7-Dimethoxy-4-{4-[3-(4-methyl-phenoxy)propoxy]phenoxy}quinoline;
(791) 6,7-Dimethoxy-4-{4-[3-(3-methyl-phenoxy)propoxy]phenoxy}quinoline;
(792) 6,7-Dimethoxy-4-{4-[3-(2-methyl-phenoxy)propoxy]phenoxy}quinoline;
(793) 6,7-Dimethoxy-4-{4-[3-(3-methoxy-phenoxy)propoxy]phenoxy}quinoline;
(794) 6,7-Dimethoxy-4-{4-[3-(4-methoxy-phenoxy)propoxy]phenoxy}quinoline;
(795) 6,7-Dimethoxy-4-{4-[3-(2-methoxy-phenoxy)propoxy]phenoxy}quinoline;
(796) 4-{4-[3-(2-Fluorophenoxy)propoxy]-phenoxy}-6,7-dimethoxyquinoline;
(797) 4-{4-[3-(3-Fluorophenoxy)propoxy]-phenoxy}-6,7-dimethoxyquinoline;
(798) 4-{4-[3-(4-Fluorophenoxy)propoxy]-phenoxy}-6,7-dimethoxyquinoline;
(799) 4-{4-[3-(2,6-Dimethylphenoxy)propoxy]-phenoxy}-6,7-dimethoxyquinoline;
(812) 6,7-Dimethoxy-4-(4-{[2-(3-methoxy-phenoxy)ethyl]sulfanyl}phenoxy)quinoline;
(813) 6,7-Dimethoxy-4-(4-{[2-(4-methoxy-phenoxy)ethyl]sulfanyl}phenoxy)quinoline;
(814) 6,7-Dimethoxy-4-(4-{[2-(4-methyl-phenoxy)ethyl]sulfanyl}phenoxy)quinoline;
(815) 4-(4-{[2-(2-Isopropylphenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(816) 4-(4-{[2-(4-Isopropylphenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(817) 6,7-Dimethoxy-4-(4-{[2-(2-methyl-phenoxy)ethyl]sulfanyl}phenoxy)quinoline;
(818) 4-(4-{[2-(4-Chlorophenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(819) 4-(4-{[2-(2-Chlorophenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(820) 4-(4-{[2-(3-Chlorophenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(821) 4-(4-{[2-(3-Fluorophenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(822) 4-(4-{[2-(2-Fluorophenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(823) 6,7-Dimethoxy-4-(4-{[2-(3-methyl-phenoxy)ethyl]sulfanyl}phenoxy)quinoline;
(824) 4-(4-{[2-(4-Fluorophenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(825) 4-(4-{[2-(2,4-Dichlorophenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(826) 4-(4-{[2-(2,4-Dimethylphenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(827) 4-(4-{[2-(3 ,4-Dimethylphenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(828) 4-(4-{[2-(2,6-Dimethylphenoxy)ethyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(829) 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl[2-(4-fluorophenoxy)ethyl]sulfone;
(830) 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl[2-(3-methoxyphenoxy)ethyl]sulfone;
(831) 2-(2,4-Dichlorophenoxy)ethyl{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}sulfone;
(832) 2-(3-Chlorophenoxy)ethyl{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}sulfone;
(833) 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenylll2-(3 ,4-dimethylphenoxy)ethyl]sulfone;
(834)-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl[2-(4-methylphenoxy)ethyl]sulfone;
(835) 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl[2-(4-isopropylphenoxy)ethyl]sulfone;
(836) 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl[2-(2-isopropylphenoxy)ethyl]sulfone;
(837) 4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl[2-(2-fluorophenoxy)ethyl]sulfone;
(838){4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}[2-(3-methoxy-4-nitrophenoxy) ethyl]sulfoxide;
(839){4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}[2-(4-fluoro-2-nitrophenoxy) ethyl]sulfoxide;
(840)[2-(2,4-Dichlorophenoxy)ethyl]{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}sulfoxide;
(841) 6,7-Dimethoxy-4-(4-{[3-(3-methyl-phenoxy)propyl]sulfanyl}phenoxy)quinoline;
(842) 4-(4-{[3-(2-Fluorophenoxy)propyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(843) 4-(4-{[4-(2-Fluorophenoxy)butyl]-sulfanyl}phenoxy)-6,7-dimethoxyquinoline;
(844) 6,7-Dimethoxy-4-(4-{[4-(3-methyl-phenoxy)butyl]sulfanyl}phenoxy)quinoline;
(851) N-[2-(2,4-Dichlorophenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}amine;
(852) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[2-(2-methylphenoxy)ethyl]amine;
(853) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[2-(2-methoxyphenoxy) ethyl]amine;
(854) N-[2-(2,6-Dichlorophenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}amine;
(855) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[2-(2,6-dimethylphenoxy) ethyl]amine;
(856) N-[2-(2,6-Dimethoxyphenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}amine;
(857) N-[2-(2,6-Difluorophenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}amine;
(858) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[2-(3 ,5-dimethylphenoxy) ethyl]amine;
(859) N-[2-(4-Chlorophenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}amine;
(860) N-[2-(3-Chlorophenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}amine;
(861) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[2-(2-ethylphenoxy)ethyl]amine;
(863) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[2-(4-methoxyphenoxy) ethyl]amine;
(864) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[2-(4-ethylphenoxy)ethyl]amine;
(865) N-[2-(2,5-Dichlorophenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}amine;
(866) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[2-(4-fluorophenoxy)ethyl]amine;
(867) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[2-(4-fluorophenoxy)ethyl]-N-methylamine;
(868) N-[2-(2-Chlorophenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}amine;
(869) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-(2-phenoxyethyl)amine;
(870) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[2-(4-methylphenoxy)ethyl]amine;
(871) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[2-(3-methylphenoxy)ethyl]amine;
(872) 2-(2-{4-[(6,7-Dimethoxy-4-quinolyl)-oxy]anilino}ethoxy)phenol;
(875) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-methylphenyl}-N-(2-phenoxyethyl)amine;
(876) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-methylphenyl}-N-[2-(2-methylphenoxy) ethyl]amine;
(877) N-[2-(2-Chlorophenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-methylphenyl}amine;
(878) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-methylphenyl}-N-[2-(3-methylphenoxy) ethyl]amine;
(879) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-methylphenyl}-N-[2-(4-methylphenoxy) ethyl]amine;
(880) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-methylphenyl}-N-[2-(2-methoxyphenoxy) ethyl]amine;
(881) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-3-methylphenyl}-N-[2-(2,6-dimethylphenoxy) ethyl]amine;
(882) N-[2-(2,6-Dimethoxyphenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-methylphenyl}amine;
(883) N-[2-(2,6-Difluorophenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-methylphenyl}amine;
(884) N-[2-(2,6-Dimethoxyphenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-amine;
(885) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-(3-phenoxypropyl)amine;
(886) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N-(3-phenoxypropyl)amine;
(887) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N-(3-phenoxypropyl)amine;
(888) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-phenyl}-N-[3-(2-methylphenoxy)propyl]amine;
(889) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N-[3-(2-methylphenoxy) propyl]amine;
(890) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N-[3-(2-methylphenoxy)propyl]amine;
(891) N-[3-(2-Chlorophenoxy)propyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}amine;
(892) N-[3-(2-Chlorophenoxy)propyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}amine;
(893) N-[3-(2-Chlorophenoxy)propyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}amine;
(894) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,3-dimethylphenyl}-N-[2-(2,6-dimethylphenoxy)ethyl]amine;
(895) N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}-N-[2-(2,6-dimethylphenoxy) ethyl]amine; and
(896) N-[2-(2,6-Dimethoxyphenoxy)ethyl]-N-{4-[(6,7-dimethoxy-4-quinolyl)oxy]-2,5-dimethylphenyl}amine.
26. A compound represented by formula (I) or a pharmacologically acceptable salt or solvate thereof:
wherein
X and Z represent —CH;
R 1 and R 2 represent C 1-4 alkoxy;
R 3 , R 4 , R 5 , and R 6 , which may be the same or different, represent a hydrogen atom; a halogen atom; C 1-4 alkyl optionally substituted by a halogen atom; C 1-4 alkoxy optionally substituted by a halogen atom; nitro; amino; or morpholyl;
wherein
at least one of R 3 , R 4 , R 5 , and R 6 represents a group other than a hydrogen atom, and
A represents group (viii):
wherein
w is an integer of 1 to 4,
L represents —O—, —S(═O) z —, wherein y is an integer of 0 to 2, or —N(—R 11 )—,
M represents —O—, —C(═O)—O—, —S(═O) z —, wherein z is an integer of 0 to 2, —N(—R 12 )—, —C(═O)—N(—R 12 )—, or —C(═O)—,
R 11 and R 12 , which may be the same or different, represent a hydrogen atom, C 1-4 alkyl optionally substituted by a halogen atom, or C 1-4 alkylcarbonyl optionally substituted by a halogen atom;
R 22 represents a hydrogen atom; C 1-4 alkyl optionally substituted by a halogen atom; or phenyl optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom, C 1-4 alkoxy optionally substituted by a halogen atom, nitro, amino, or a halogen atom,
when M represents —N(—R 12 )— or —C(═O)—N(—R 12 )—, R 22 and R 12 may form a five- to seven-membered saturated or unsaturated heterocyclic ring optionally containing one or more additional hetero-atoms together with the nitrogen atom to which they are attached, this heterocyclic ring is optionally condensed with another carbocyclic ring or heterocyclic ring to form a ten- to twelve-membered bicyclic saturated or unsaturated heterocyclic ring, and these heterocyclic rings are optionally substituted by C 1-4 alkyl optionally substituted by a halogen atom; phenyl; benzyl; or piperidine.
27. A composition comprising:
the compound of claim 1 or a pharmacologically acceptable salt thereof or a solvate thereof.
28. A method for treating a disease mediated by the autophosphorylation of a PDGF receptor comprising:
administering to a subject in need thereof an effective amount of the compound of claim 1 , wherein said disease is selected from the group consisting of angiostenosis, chronic rheumatism, and organ fibrosis.
29. A method for treating a disease mediated by the autophosphorylation of a PDGF receptor comprising administering to a subject in need thereof an effective amount of the compound of claim 1 , wherein said disease is myeloid leukemia.
30. A method for inhibiting angiostenosis comprising administering an amount of the compound of claim 1 effective to inhibit angiostenosis.