Devices and methods for treating defects in the tissue of a living being
View Patent ↗An implant for deployment in select locations or select tissue for regeneration of tissue is disclosed. The implant comprising collagen and or other bio-resorbable materials, where the implant may also be used for therapy delivery. Additionally, the implant may be “matched” to provide the implant with similar physical and/or chemical properties as the host tissue.
1. An implant for the repair or regeneration of a bone defect in a living being, said implant comprising an osteoconductive matrix, comprising a blend of soluble collagen and native collagen fibers, wherein at least a portion of said implant is porous, and further wherein said porous implant has a pore size that is at least about 100 microns, and still further wherein said porous implant is arranged to be implanted in the body of said living being.
2. The implant of claim 1 , wherein said matrix further comprises at least one osteoinductive factor.
3. The implant of claim 2 , wherein said osteoinductive factor comprises cells.
4. The implant of claim 1 , wherein said matrix further comprises at least one therapy.
5. The implant of claim 4 , wherein said therapy comprises at least one drug or biologically active agent.
6. The implant of claim 1 , wherein said matrix further comprises at least one additional polymer.
7. The implant of claim 6 , wherein said additional polymer is synthetic.
8. The implant of claim 6 , wherein said additional polymer is at least partially bio-resorbable.
9. The implant of claim 8 , wherein said additional polymer comprises chitin, PGA/PLLA copolymers, hydrogel, Lactide/μ-caprolactone copolymers, PGA, PLA, or PCL.
10. The implant of claim 6 , wherein said additional polymer comprises microspheres.
11. The implant of claim 10 , wherein said microspheres are arranged for a time-staged delivery of a therapy.
12. The implant of claim 11 , wherein said time-staged delivery comprises a plurality of delivery stages.
13. The implant of claim 12 , wherein said delivery stages deliver a plurality of therapies.
14. The implant of claim 13 , wherein said therapies are not compatible, said delivery stages being further arranged to be separated by a non-delivery stage.
15. The implant of claim 14 , wherein at least one of said therapies comprises a drug or biologically active agent.
16. The implant of claim 6 , wherein said additional polymer is osteoinductive.
17. The implant of claim 1 , wherein said osteoconductive matrix further comprises at least one ceramic.
18. The implant of claim 17 , wherein said ceramic comprises calcium phosphate, calcium sulfate, or hydroxyapatite.
19. The implant of claim 17 , wherein said at least one ceramic is in the form of particles blended with said osteoconductive matrix.
20. The implant of claim 1 , wherein said matrix further comprises reconstituted collagen.
21. The implant of claim 1 , wherein said osteoconductive matrix is bio-matched.
22. The implant of claim 21 , wherein said bio-matched, osteoconductive matrix comprise a matrix that is at least one of integrity matched, porosity matched, compliance matched or weight matched.
23. The implant of claim 1 , wherein said osteoconductive matrix exhibits elastic recovery after being compressed.
24. The implant of claim 1 , wherein said pores make up more than 50 percent by volume of said porous portion.
25. The implant of claim 1 , wherein said implant is located at a site of said bone defect.
26. An implant for the repair or regeneration of a bone defect of a living being, said implant comprising an osteoconductive matrix comprising a blend of soluble collagen and native collagen fibers, wherein at least a portion of said implant is porous, and further wherein said implant being in a form selected from the group consisting of a sponge and a loose, fibrous material, and still further wherein said implant is suitable for implantation in the body of said living being, and is in fact located at a site of said bone defect.