Compositions and methods for darkening the skin
View Patent ↗The present invention relates to a method of darkening the skin by topically applying to the skin a peptide and compositions containing such peptides.
1. A method of darkening the skin, said method comprising topically applying to the skin a peptide of the formula
wherein R 1 , R 2 , and R 3 , independently, are selected from the group consisting or H, Cl, or F; and
R 4 is OH, NH 2 , C 1-12 alkoxy, C 7-10 phenylalkoxy, C 11-20 naphthylalkoxy, C 1-12 alkylamino, C 7-10 phenylalkylamino, or C 11-20 naphthylalkylamino;
or a cosmetically acceptable salt thereof.
2. A method of claim 1 , wherein said peptide is of the formula
3. A method of claim 1 , wherein R 1 , R 2 , and R 3 are all H and R 4 is OH or NH 2 .
4. A method of claim 2 , wherein R 1 , R 2 , and R 3 are all H and R 4 is OH or NH 2 .
5. A method of darkening the skin, said method comprising topically applying to the skin a composition comprising:
(a) a peptide of the formula
wherein R 1 , R 2 , and R 3 , independently, are selected from the group consisting or H, Cl, or F; and R 4 is OH, NH 2 , C 1-12 alkoxy, C 7-10 phenylalkoxy, C 11-20 naphthylalkoxy, C 1-12 alkylamino, C 7-10 phenylalkylamino, or C 11-20 naphthylalkylamino; or a cosmetically acceptable salt thereof; and
(b) a cosmetically-acceptable carrier.
6. A method of claim 5 , wherein said peptide is of the formula
7. A method of claim 5 , wherein R 1 , R 2 , and R 3 are all H and R 4 is OH or NH 2 .
8. A method of claim 6 , wherein R 1 , R 2 , and R 3 are all H and R 4 is OH or NH 2 .
9. A method of claim 5 , wherein said composition further comprises a pigment selected from the group consisting of melanin, a derivative of melanin, or a plant extract, wherein said derivative of melanin is a polymer comprising monomeric units selected from the group consisting of dihydroxyindole-carboxylic acids, 3-aminotyrosine, 3,4-dihydroxybenzoic acid, 3- amino,4-hydroxybenzoic acid, aloin, emodin, alizarin, tyrosine, dihydroxyphenylalanine, 4,5-dihydroxynaphthalene-2-sulfonic acid, 3-nitrotyrosine, 3-dimethylamino phenol and p-aminobenzoic acid and said plant extract is an extract from a plant of the hedychium genus or bearberry genus.
10. A method of claim 8 , wherein said composition further comprises a pigment selected from the group consisting of melanin, a derivative of melanin, or a plant extract, wherein said derivative of melanin is a polymer comprising monomeric units selected from the group consisting of dihydroxyindole-carboxylic acids, 3-aminotyrosine, 3,4-dihydroxybenzoic acid, 3- amino,4-hydroxybenzoic acid, aloin, emodin, alizarin, tyrosine, dihydroxyphenylalanine, 4,5-dihydroxynaphthalene-2-sulfonic acid, 3-nitrotyrosine, 3-dimethylamino phenol and p-aminobenzoic acid and said plant extract is an extract from a plant of the hedychium genus or bearberry genus.
11. A method of claim 5 , wherein said composition comprises from about 0.001 to about 1 percent, by weight, of said peptide.
12. A method of claim 8 , wherein said composition comprises from about 0.001 to about 1 percent, by weight, of said peptide.
13. A method of claim 9 , wherein said composition comprises from about 0.001 to about 1 percent, by weight, of said peptide and from about 0.0001 to about 1 percent, by weight, of said pigment.
14. A method of claim 10 , wherein said composition comprises from about 0.001 to about 1 percent, by weight, of said peptide and from about 0.000 1 to about 1 percent, by weight, of said pigment.
15. A composition comprising:
(a) a peptide of the formula
wherein R 1 , R 2 , and R 3 , independently, are selected from the group consisting or H, Cl, or F; and R 4 is OH, NH 2 , C 1-12 alkoxy, C 7-10 phenylalkoxy, C 11-20 naphthylalkoxy, C 1-12 alkylamino, C 7-10 phenylalkylamino, or C 11-20 naphthylalkylamino; or a cosmetically acceptable salt thereof; and
(b) a cosmetically-acceptable carrier.
16. A composition of claim 15 , wherein said peptide is of the formula
17. A composition of claim 15 , wherein R 1 , R 2 , and R 3 are all H and R 4 is OH or NH 2 .
18. A composition of claim 16 , wherein R 1 , R 2 , and R 3 are all H and R 4 is OH or NH 2 .
19. A composition of claim 15 , wherein said composition further comprises a pigment selected from the group consisting of melanin, a derivative of melanin, or a plant extract, wherein said derivative of melanin is a polymer comprising monomeric units selected from the group consisting of dihydroxyindole-carboxylic acids, 3-aminotyrosine, 3,4-dihydroxybenzoic acid, 3- amino,4-hydroxybenzoic acid, aloin, emodin, alizarin, tyrosine, dihydroxyphenylalanine, 4,5-dihydroxynaphthalene-2-sulfonic acid, 3-nitrotyrosine, 3-dimethylamino phenol and p-aminobenzoic acid and said plant extract is an extract from a plant of the hedychium genus or bearberry genus.
20. A composition of claim 18 , wherein said composition further comprises a pigment selected from the group consisting of melanin, a derivative of melanin, or a plant extract, wherein said derivative of melanin is a polymer comprising monomeric units selected from the group consisting of dihydroxyindole-carboxylic acids, 3-aminotyrosine, 3,4-dihydroxybenzoic acid, 3- amino,4-hydroxybenzoic acid, aloin, emodin, alizarin, tyrosine, dihydroxyphenylalanine, 4,5-dihydroxynaphthalene-2-sulfonic acid, 3-nitrotyrosine, 3-dimethylamino phenol and p-aminobenzoic acid and said plant extract is an extract from a plant of the hedychium genus or bearberry genus.
21. A composition of claim 15 , wherein said composition comprises from about 0.00 1 to about 1 percent, by weight, of said peptide.
22. A composition of claim 18 , wherein said composition comprises from about 0.00 1 to about 1 percent, by weight, of said peptide.
23. A composition of claim 19 , wherein said composition comprises from about 0.00 1 to about 1 percent, by weight, of said peptide and from about 0.0001 to about 1 percent, by weight, of said pigment.
24. A composition of claim 20 , wherein said composition comprises from about 0.00 1 to about 1 percent, by weight, of said peptide and from about 0.000 1 to about 1 percent, by weight, of said pigment.
25. A method of claim 9 , wherein said pigment is melanin or a derivative of melanin, wherein said derivative of melanin is a polymer comprising monomeric units selected from the group consisting of dihydroxyindole-carboxylic acids, 3-aminotyrosine, 3,4-dihydroxybenzoic acid, 3- amino,4-hydroxybenzoic acid, aloin, emodin, alizarin, tyrosine, dihydroxyphenylalanine, 4,5-dihydroxynaphthalene-2-sulfonic acid, 3- nitrotyrosine, 3-dimethylamino phenol and p-aminobenzoic acid.
26. A composition of claim 9 , wherein said pigment is melanin or a derivative of melanin, wherein said derivative of melanin is a polymer comprising monomeric units selected from the group consisting of dihydroxyindole-carboxylic acids, 3-aminotyrosine, 3,4-dihydroxybenzoic acid, 3- amino,4-hydroxybenzoic acid, aloin, emodin, alizarin, tyrosine, dihydroxyphenylalanine, 4,5-dihydroxynaphthalene-2-sulfonic acid, 3-nitrotyrosine, 3-dimethylamino phenol and p-aminobenzoic acid.
27. A method of claim 9 , wherein said pigment is a plant extract from a plant of the hedychium genus or bearberry genus.
28. A composition of claim 9 , wherein said pigment is a plant extract from a plant of the hedychium genus or bearberry genus.