Agent for diagnosing and treating malignant tumors
View Patent ↗A composition of a compound or derivative thereof in which at least one carbon atom of 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and where said derivative is an ester, amide, salt, hydrate or solvate of the compound, and a diagnostically acceptable carrier. A method for detecting malignant tumors, by administering a tumor detecting effective amount to a host in need of tumor detection of a compound or derivative thereof in which at least one carbon atom of 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and where said derivative is an ester, amide, salt, hydrate or solvate of said compound and detecting the malignant tumors using NMR.
1. A method for detecting malignant tumors, which method comprises administering a tumor detecting effective amount, to a host in need of malignant tumor detection, of 5-aminolevulinic acid or a derivative thereof in which at least one carbon atom of said 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and where said derivative is an ester, amide, salt, hydrate or solvate of said 5-aminolevulinic acid; and
detecting the malignant tumors using NMR.
2. The method of claim 1 wherein said 5-aminolevuliic acid or derivative thereof is used in combination with a diagnostically acceptable carrier.
3. The method of claim 1 , wherein the malignant tumors are detected in a living host.
4. The method of claim 1 , wherein the carbon isotope is used and it is the 13 C or 14 C isotope.
5. The method of claim 4 , wherein the carbon isotope is used and it is the 13 C isotope and the NMR is 13 C-NMR.
6. The method of claim 1 , wherein the nitrogen isotope is used and it is the 15 N isotope.
7. The method of claim 1 , wherein said derivative is used and said derivative is the ester.
8. The method of claim 1 , wherein said derivative is used and said derivative is the amide.
9. The method of claim 1 , wherein said derivative is used and said derivative is the salt.
10. The method of claim 1 , wherein said derivative is used and said derivative is the hydrate.
11. The method of claim 1 , wherein said derivative is used and said derivative is the solvate.
12. The method of claim 1 , wherein the detecting is conducted using a total dose of from 10 mg to 10 g per kg of body weight.
13. The method of claim 1 , wherein said malignant tumors exist in a deep region of tissue.