Generator for rhenium-188
View Patent ↗Radioisotope generators comprising inorganic layered hydroxide composition, such as magnesium aluminates and lithium aluminates. These inorganic layered hydroxides form anion exchange materials that exhibit surprisingly high selective affinities for certain radioisotopes. Inorganic layered hydroxides have been prepared and shown to have high affinity for tungstate anions, the anion form of tungsten-188, yet low affinity for perrhenate anions, the anion form of rhenium-188.
1. A rhenium-188 generator comprising an elutable container defining an eluant flow path, the container containing a matrix comprising a substantially non-elutable inorganic layered hydroxide compound containing tungsten-188.
2. The generator of claim 1 , wherein the inorganic layered hydroxide composition comprises hydrotaicite structured anion exchange material.
3. The generator of claim 2 , wherein the hydrotalcite structured material comprises a magnesium aluminate.
4. The generator of claim 3 , wherein the hydrotalcite is prepared by reacting aluminum hydroxide with a magnesium salt.
5. The generator of claim 4 , wherein the magnesium salt is magnesium chloride.
6. The generator of claim 1 , wherein the inorganic layered hydroxide composition comprises a lithium aluminate.
7. The generator of claim 6 , wherein the lithium aluminate is prepared by reacting a lithium salt wit hydrous alumina.
8. The generator of claim 1 , wherein the tungsten-188 is provided in the form of a tungstate anion.
9. The generator of claim 3 , wherein the tungsten-188 is provided in the form of a tungstate anion.
10. The generator of claim 6 , wherein the tungsten-188 is provided in the form of a tungstate anion.
11. The generator of claim 8 , wherein the tungstate anion is exchanged onto the inorganic layered hydroxide at a pH between 6.5 and 7.
12. The generator of claim 10 , wherein the tungstate anion is provided as a sodium tungstate solution.
13. A radionuclide generator for producing rhenium-188 comprising an insoluble inorganic layered hydroxide matrix including a tungstate compound containing tungsten-188, the matrix being permeable to fluid passage and permitting diffusion of rhenium-188 therethrough.
14. The radionuclide generator of claim 13 , wherein the matrix is prepared by reacting aluminum hydroxide with magnesium chloride.
15. The radionuclide generator of claim 13 , wherein the matrix has a hydrotalcite structure.
16. The radionuclide generator of claim 15 , wherein the hydratalcite structured compound has a magnesium to aluminum ratio of between about 0.5 and about 2.
17. The generator of claim 13 , wherein the matrix is prepared by reacting lithium salt with hydrous alumina.
18. The generator of claim 13 , wherein the matrix comprises a lithium aluminate.
19. A process for preparing a radionuclide generator useful for producing a solution containing rhenium-188, comprising:
disposing a substantially non-elutable inorganic layered hydroxide anion exchange composition into a container defining an eluant flow path; and
exchanging tungstate anions onto the anion exchange composition.
20. The process of claim 19 , wherein the anion exchange composition is a magnesium aluminate.
21. The process of claim 19 , wherein the anion exchange composition is a lithium aluminate.
22. The process of claim 19 , further comprising:
reacting aluminum hydroxide with a magnesium salt to form the anion exchange composition.
23. The process of claim 22 where the magnesium salt is magnesium chloride.
24. The process of claim 17 , wherein the tungstate anions are provided by a sodium tungstate solution.
25. The process of claim 20 , wherein the tungstate anions are provided by a sodium tungstate solution.
26. The process of claim 19 , wherein the step of exchanging is performed at a pH between 6.5 and 7.
27. The process of claim 19 , wherein the tungstate anions exchange with up to 10% of the theoretical anion exchange capacity of the anion exchange composition.
28. A process for preparing a perrhenate solution, comprising:
eluting perrhenate from a matrix consisting essentially of an insoluble inorganic layered hydroxide in the tungstate form.
29. The process of claim 28 , wherein the inorganic layered hydroxide comprises a combination of cations selected from magnesium/aluminum, lithium/aluminum, and magnesium/lithium.
30. The process of claim 28 , further comprising:
reacting aluminum hydroxide with a magnesium salt to form the insoluble inorganic layered hydroxide; and
loading the insoluble inorganic layered hydroxide with tungstate anions.
31. The process of claim 30 where the magnesium salt is magnesium chloride.
32. The process of claim 30 , wherein the step of loading further comprises:
forming an aqueous slurry of the insoluble inorganic layered hydroxide; and
adding sodium tungstate to the slurry.
33. The process of claim 32 , further comprising:
agitating the slurry.
34. The process of claim 32 , further comprising:
maintaining the pH of the slurry between 6.5 and 7.
35. The process of claim 32 , further comprising:
separating the insoluble inorganic layered hydroxide from the slurry.
36. The process of claim 28 , wherein the step of eluting is performed with an eluant that is an aqueous solution.
37. The process of claim 28 , wherein the step of eluting is performed with an eluant solution including a salt.
38. The process of claim 28 , wherein the step of eluting is performed with an eluant having neutral pH.
39. The process of claim 28 , wherein the perrhenate solution has a radiochemical purity of greater than 99%.
40. The process of claim 28 , wherein the insoluble inorganic layered hydroxide exhibits a tungstate distribution factor greater-tan 1,000 milliliters/gram.
41. The process of claim 28 , wherein the insoluble inorganic layered hydroxide exhibits a tungstate distribution factor greater than 5,000 milliliters/gram.
42. The process of claim 28 , wherein the insoluble inorganic layered hydroxide exhibits a tungstate distribution factor greater than 10,000 milliliters/gram.
43. The process of claim 28 , wherein the insoluble inorganic layered hydroxide exhibits a tungstate distribution factor greater than 15,000 milliliters/gram.
44. The process of claim 28 , further comprising:
purifying the perrhenate by passing the perrhenate trough a secondary matrix capable of adsorbing tungsten.
45. The process of claim 28 , further comprising:
obtaining rhenium-188 from the perrhenate; and
conjugating the rhenium-188 to an antibody.
46. The process of claim 28 , further comprising:
obtaining rhenium-188 from the perrhenate; and
conjugating the rhenium-188 to an antibody that recognizes tumor-associated antigens.
47. The process of claim 28 , wherein the elated perrhenate has the formula (ReO 4 ).
48. The process of claim 28 , wherein the perrhenate is formed by radioactive decay of the tungstate.
49. The process of claim 28 , wherein the eluted perrhenate is in the form of sodium perrhenate (Na + ReO 4 ).
50. The process of claim 28 , further comprising:
concentrating the perrhenate in a secondary anion exchange column; and
eluting the concentrated perrhenate from the anion-exchange column with a saline solution.
51. The process of claim 28 , characterized in that the perrhenate is eluted as a solution having a volume between 0.5 and 50 milliliters and containing greater than 10 millicuries of rhenium-188.
52. The process of claim 28 , wherein the inorganic layered hydroxide comprises a mixture of at least two cations with surrounding shells of bound hydroxyl groups.
53. The process of claim 28 , where the inorganic layered hydroxide is selected from magnesium aluminate and lithium aluminate.