Neisserial vaccine compositions and methods
View Patent ↗Methods and compositions for the treatment of microbial infection, and in particular meningococcal disease, comprise a commensal Neisseria or an extract of a commensal Neisseria . Further methods and compositions comprise conimensal Neisseria which express genes from virulent strains of Neisseria and/or heterologous gene products from non-Neisserial sources. Such compositions are used in vaccine preparations for the treatment of microbial infection.
1. A composition comprising an outer membrane preparation or an outer membrane vesicle preparation of a commensal Neisseria that expresses a gene product heterologous to said commensal Neisseria.
2. The composition of claim 1 , wherein said cormnensal Neisseria is selected from the group consisting of N. lactamica, N. cinerea, N. elongata, N. flavescens, N. polysaccharea, N. sicca , and N. subflava.
3. The composition of claim 1 , wherein said commensal Neisseria is N. lactamica.
4. The composition of claim 1 , wherein said heterologous gene product is of a pathogenic Neisseria.
5. The composition of claim 1 , wherein said heterologous gene product is selected from the group consisting of a transferrin binding protein, a porin, Neisserial surface protein A (NspA), an outer membrane protein, and a Cu, Zn-superoxide dismutase.
6. The composition of claim 1 , wherein said preparation is extracted from said commensal Neisseria.
7. A composition comprising an outer membrane preparation or an outer membrane vesicle preparation of a commensal Neisseria which comprises and expresses a gene of a pathogenic Neisseria and a pharmaceutically acceptable carrier.
8. The composition of claim 7 , wherein said commensal Neisseria is selected from the group consisting of N. lactamica, N. cinerea, N. elongata, N. flavescens, N. polysaccharea, N. sicca , and N. subflava.
9. The composition of claim 7 , wherein said commensal Neisseria is N. lactamica.
10. The composition of claim 7 , wherein said gene is a N. meningitidis gene which codes for a protein selected from the group consisting of a transferrin binding protein, a porin, Neisserial surface protein A (NspA), an outer membrane protein, and a Cu, Zn-superoxide dismutase.
11. The composition of claim 7 , wherein said preparation is extracted from said commensal Neisseria.