Sulfacetamide formulations for treatment of rosacea
View Patent ↗The present invention provides improved sulfacetamide and sulfur formulations including sunscreens for the treatment of rosacea.
1. A topical composition for the treatment of mammalian skin dermatoses comprising at least one sulfacetamide or a derivative thereof and at least one sunscreen.
2. The topical composition of claim 1 wherein the sulfacetamide is sodium sulfacetamide.
3. The topical composition of claim 1 used for the treatment of rosacea.
4. The topical composition of claim 1 wherein the formulation further comprises sulfur.
5. The topical composition of claim 1 wherein the sunscreen blocks the absorption of UV radiation.
6. The topical composition of claim 1 wherein the sunscreen absorbs UV A and UV B radiation.
7. The topical composition of claim 6 where the absorption of UV A and UV B is provided by at least two different sunscreens.
8. The topical composition of claim 6 wherein the sunscreen is selected from at least one of the following: avobenzone, octocrylene, octyl methoxycinnamate or oxybenzone.
9. A topical composition of claim 5 wherein the sunscreen is an inorganic oxide.
10. A topical composition of claim 9 wherein the sunscreen is selected from the group of titanium dioxide or zinc oxide.
11. The topical composition of claim 8 wherein the sunscreen is present from about 0.1% to about 25% by weight.
12. The composition of claim 1 wherein the sunscreen is present in a sufficient amount to produce a sun protection factor of at least 2.
13. The topical composition of claim 1 wherein the composition further comprises benzyl alcohol.
14. The topical composition of claim 13 wherein the benzyl alcohol is present from about 0.1 to about 10% by weight.
15. The topical composition of claim 13 wherein the benzyl alcohol is present from about 0.5 to 2.5% by weight.
16. A method of treating mammalian dermatoses by administering a topical composition comprising at least one sulfacetamide or a derivative thereof and at least one sunscreen.
17. The method of 16 wherein the sulfacetamide is sodium sulfacetamide.
18. The method of claim 16 wherein the topical composition further comprises sulfur.
19. The method of claim 16 wherein the sunscreen blocks the absorption of UV radiation.
20. The method of claim 16 wherein sunscreen absorbs UVA and UVB radiation.
21. The method of claim 16 wherein at least two different sunscreens are used to absorb UV A and UVB radiation.
22. The method of claim 16 wherein the sunscreen is selected from at least one of the following: avobenzone, octocrylene, octyl methoxycinnamate or oxybenzone.
23. The method of claim 16 wherein the sunscreen is selected from an inorganic oxide.
24. The method of claim 23 wherein the sunscreen is selected the group consisting of titanium dioxide or zinc oxide.
25. The method of claim 22 wherein the sunscreen is present from about 0.1 to about 10 percent by weight.
26. The method of claim 16 wherein the sunscreen is present in an amount sufficient to produce a sun protection factor of at least 2.
27. The method of claim 16 wherein the sunscreen is present from about 0.1 to about 10 percent by weight.
28. The method of claim 16 wherein topical composition further comprises benzyl alcohol.
29. The method of claim 16 wherein the treatment results in a reduction of redness, inflammation, lesions or microorganisms.
30. The method of claim 16 wherein the wherein the dermatoses is acne, rosacea, or a skin infection.
31. The method of claim 18 wherein treatment results in a reduction of redness, inflammation, lesions or microorganisms.
32. The method of claim 18 wherein the dermatoses is acne, rosacea, or a skin infection.
33. The method of claim 19 wherein treatment results in a reduction of redness, inflammation, lesions or microorganisms.
34. The method of claim 19 wherein the dermatoses is acne, rosacea, or a skin infection.
35. The method of claim 20 where treatment results in a reduction of redness, inflammation, lesions or microorganisms.
36. The method of claim 20 wherein the dermatoses is acne, rosacea, or a skin infection.
37. The method of claim 21 where treatment results in a reduction of redness, inflammation, lesions or microorganisms.
38. The method of claim 21 wherein the dermatoses is acne, rosacea, or a skin infection.
39. The method of claim 22 where treatment results in a reduction of redness, inflammation, lesions or microorganisms.
40. The method of claim 22 wherein the dermatoses is acne, rosacea, or a skin infection.
41. The method of claim 23 where treatment results in a reduction of redness, inflammation, lesions or microorganisms.
42. The method of claim 23 wherein the dermatoses is acne, rosacea, or a skin infection.
43. The method of claim 24 where treatment results in a reduction of redness, inflammation, lesions or microorganisms.
44. The method of claim 24 wherein the dermatoses is acne, rosacea, or a skin infection.
45. The method of claim 25 where treatment results in a reduction of redness, inflammation, lesions or microorganisms.
46. The method of claim 25 wherein the dermatoses is acne, rosacea, or a skin infection.
47. The method of claim 26 where treatment results in a reduction of redness, inflammation, lesions or microorganisms.
48. The method of claim 26 wherein the dermatoses is acne, rosacea, or a skin infection.
49. The method of claim 27 where treatment results in a reduction of redness, inflammation, lesions or microorganisms.
50. The method of claim 27 wherein the dermatoses is acne, rosacea, or a skin infection.
51. A topical composition for the treatment of mammalian skin dermatoses comprising at least one sulfacetamide and at least one sunscreen, wherein the composition is chemically stable for more than 180 days at 25° C.
52. A topical composition for the treatment of mammalian skin dermatoses comprising sulfacetamide and at least one sunscreen, wherein the composition exhibits less than 10% decomposition of claim sulfacetamide or sunscreen after storage at 25° C. for 180 days.
53. The composition of claim 51 wherein the composition further comprises sulfur.
54. The composition of claim 51 wherein the composition further comprises benzyl alcohol.
55. The composition of claim 52 wherein the composition further comprises sulfur.
56. The composition of claim 52 wherein the composition further comprises benzyl alcohol.
57. The composition of claim 51 wherein the sunscreen is selected from at least one of the following: avobenzone, octocrylene, octyl methoxycinnamate, oxybenzone, zinc oxide or titanium oxide.
58. The composition of claim 52 wherein the sunscreen is selected from at least one of the following: avobenzone, octocrylene, octyl methoxycinnamate, oxybenzone, zinc oxide or titanium oxide.
59. The composition of claim 51 wherein the sunscreen is present in an amount sufficient to provide a sun protection factor of at least 2.
60. The composition of claim 52 wherein the sunscreen is present in an amount sufficient to provide a sun protection factor of at least 2.