Gastrointestinal compositions

1. A composition for treating or gastrointestinal disorders, comprising:

a.) a safe and effective amount of an amino-ether and/or -ester oxide having the formula:

 in which: R 1 is a lower alkyl, R 2 and R 3 which are the same or different are hydrogen or lower alkyl, R 4 is a phenyl or phenoxy nucleus optionally monosubstituted to trisubstituted by substituents which are identical or different, halogen or lower alkoxy, R 5 is a phenyl radical optionally monosubstituted to trisubstituted by substituents which are the same or different, halogen, lower alkyl, lower alkoxy or nitro, a pyridyl radical or a lower alkyl radical, Q is —O— or —COO—, n is equal to zero 1 or 2, m and q are, independently of one another, equal to zero or to 1, wherein the amino-ether and/or -ester oxide is selected from the group consisting of trimebutine, fedotozine and mixtures thereof; and

b.) a safe and effective amount of a gastrointestinal active selected from the group consisting of laxatives, antidiarrheals, antibiotics, antiulceratives, gastric secretion inhibitors, peristalitc stimulants, serotonin (5HT 3 ) receptor antagonists, serotonin (5HT 4 ) receptor agonists, selective serotonin reuptake inhibitor and mixture thereof; and

c.) an anti-inflammatory compound.

2. A composition according to claim 1 , wherein the laxative is selected from the group consisting of methylcellulose, carboxymehylcellulose sodium, malt soup extract, polyacrylic resin, plantago seeds, dioctyl calcium sulfosuccinate, dioctyl potassium sulfosuccinate, dioctyl sodium sulfosuccinate, mineral oil, magnesium citrate, magnesium hydroxide, magnesium sulfate, dibasic sodium phosphate, monobasic sodium phosphate, sodium biphosphate, glycerin, anthraquinones, diphenylmethanes, castor oil and mixtures thereof.

3. A composition according to claim 1 , wherein the antidiarrheal is selected from the group consisting of natural opiates, synthetic opiates, anticholinergics, acetyltannic acid, albumin tannate, alkofanone, aluminum salicylates, catechin, lidamidine, mebiquine, trillium, uzarin and mixtures thereof.

4. A composition according to claim 1 , wherein the antiulcerative is selected from the group consisting of aceglutamide aluminum complex, ε-acetamidocaproic acid zinc salt, acetoxolone, arbaprostil, benexate hydrochloride, bismuth subcitrate sol (dried), carbenoxolone, cetraxate, cimetidine, enprostil, esaprazole, famotidine, ftaxilide, gefarnate, guaiazulene, irsogladine, nizatidine, omeprazole, omoprostil, γ-oryzanol, pifarnine, pirenzepine, plaunotol, ranitidine, rioprostil, rosaprostol, rotraxate, roxatidine acetate, sofalcone, spizofurone, sucralfate, teprenone, trimoprostil, thrithiozine, troxipide, zolimidine and mixtures thereof.

5. A composition according to claim 1 , wherein the gastric secretion inhibitor is selected from the group consisting of enterogastrone, octreotide and mixtures thereof.

6. A composition according to claim 1 , wherein the peristalitc stimulant is selected from the group consisting of metoclopromide, cisapride, domperidone and mixtures thereof.

7. A composition according to claim 1 , wherein the serotonin (5HT 3 ) receptor antagonist is selected from the group consisting of renzapride cilansetron, ondansetron, alosetron and mixtures thereof.

8. A composition according to claim 1 , wherein the serotonin (5HT 4 ) receptor agonist is selected from the group consisting of tegaserod, prucalopride and mixtures thereof.

9. A composition according to claim 1 , wherein the selective serotonin reuptake inhibitor is selected from the group consisting of fluoxetine, fluvoxamine, paroxetine, sertraline and mixtures thereof.

10. A composition according to claim 1 , wherein antibiotic is selected from the group consisting of nitroimidazole antibiotics, tetracyclines, pencillins, cephalosporins, carbopenems, amino-glycosides, macrolide antibiotics, lincosamide antibiotics, 4-quinolones, rifamycins, nitrofurantoin and derivatives of 10-(1-hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0.3.8]undec-2-ene-2-carboxylic acid and mixtures thereof.

11. A composition according to claim 1 , wherein the antiinflammatory compound is selected from the group consisting of corticosteroids, non-steroidal antiinflammatory compounds and mixtures thereof.

12. A composition according to claim 11 , wherein the antiinflammatory compound is a non-steroidal antiinflammatory compound.

13. A composition according to claim 1 , in the form of a tablet, capsule, microcapsule, suspension, solution, injectable, rectal suppository, rectal cream, rectal ointment, rectal gel.

14. A composition according to claim 1 , wherein the gastrointestinal active is a laxative.

15. A composition according to claim 1 , wherein the laxative is a bulk forming laxative.

16. A composition according to claim 1 , wherein the laxative is selected from the group consisting of polycarbophil, calcium polycarbophil and mixtures thereof.

17. A composition for treating or gastrointestinal disorders according claim 1 , comprising:

a.) a safe and effective amount of trimebutine, and

b.) a safe and effective amount of polycarbophil.

18. A composition for treating or gastrointestinal disorders according claim 1 , comprising:

a.) a safe and effective amount of fedotozine; and

c.) a safe and effective amount of polycarbophil.