IP Library Granted Patent US 7,074,767
Granted Patent B2
US 7,074,767 · App. 10/201,206 · Granted Jul 11, 2006

Preparation of a therapeutic composition

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Quick Facts
Patent No.
US 7,074,767
App. No.
10/201,206
Granted
Jul 11, 2006
Kind
B2
Abstract

Product R, a novel therapeutic composition for treating viral infections and stimulating the immune system, comprises a unique peptide having 31 amino acids and another unique peptide having 21 amino acids and connected with an oligo-nucleotide through a diphosphodiester or diphosphodithioate ester linkage. The composition has a light absorption spectrum with typical absorption ratios of 1.998 at 260 nm/280 nm and 1.359 at 260 nm/230 nm.

Claims (12)

1. A purified peptide of SEQ ID NO: 1.

2. The purified peptide of claim 1 , wherein said peptide is formed by a process comprising the steps of:

a) forming a mixture including a protein combination consisting of casein, beef peptone and bovine serum albumin, a plant RNA and a base in water, wherein the ratio of said protein combination to said water is in a range from about 1.5/100 to about 2.5/100 by weight.

b) processing said mixture at an elevated temperature and an elevated pressure so as to form a solution and insoluble elements;

c) removing said insoluble elements;

d) diluting said solution with water; and

e) after performing steps b, c and d, adjusting the pH of said solution to a physiologically acceptable pH.

3. The purified peptide of claim 1 , wherein said peptide is chemically synthesized.

4. A pharmaceutical composition, comprising a purified peptide of SEQ ID NO: 1 and a pharmaceutically acceptable carrier.

5. A pharmaceutical composition, comprising (a) a purified peptide of 31 amino acids, lacking any cysteine-cysteine cross links, comprising six proline residues and four glutamine residues, and being capable of stimulating the production of interleukin-8 in cultured cells; and (b) a pharmaceutically acceptable carrier.

6. A pharmaceutical composition, comprising (a) a purified peptide of 31 amino acids, lacking any cysteine-cysteine cross links, comprising six proline residues and four glutamine residues, and being capable of stimulating the production of monocyte chemotactic protein 1 in cultured cells; and (b) a pharmaceutically acceptable carrier.

7. The purified peptide of claim 2 , wherein said elevated temperature is about 150 to 300° F. and said elevated pressure is 5 to 15 lbs.

Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 30, 2013
From: FRIEDLAND, BERNARD; HIRSCHMAN, SHALOM Z.; TARAPOREWALA, IRACH B.
To: ADVANCED VIRAL RESEARCH CORP.
Reel/Frame 031858/0757 →
MERGER Recorded Dec 30, 2013
From: BBM HOLDINGS, INC.
To: OHR PHARMACEUTICAL, INC.
Reel/Frame 031858/0836 →
SECURITY AGREEMENT Recorded May 20, 2009
From: BBM HOLDINGS, INC.
To: YA GLOBAL INVESTMENTS, L.P.
Reel/Frame 022708/0679 →
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY PREVIOUSLY RECORDED ON REEL 022542 FRAME 0001. ASSIGNOR(S) HEREBY CONFIRMS THE OWNERSHIP TRANSFERED FROM ADVANCED VIRAL RESEARCH CORP. AND TRIAD BIOTHERAPEUTICS, INC. TO BBM HOLDINGS, INC. Recorded Apr 30, 2009
From: ADVANCED VIRAL RESEARCH CORP.; TRIAD BIOTHERAPEUTICS, INC.
To: BBM HOLDINGS, INC.
Reel/Frame 022629/0569 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNOR/ASSIGNEE NAMES PREVIOUSLY RECORDED ON REEL 022510 FRAME 0187. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNORS ARE ADVANCED VIRAL RESEARCH CORP. AND TRIAD BIOTHERAPEUTICS, INC., AND THE ASSIGNEE IS YA GLOBAL INVESTMENTS, L.P. Recorded Apr 14, 2009
From: ADVANCED VIRAL RESEARCH CORP.; TRIAD BIOTHERAPEUTICS, INC.
To: YA GLOBAL INVESTMENTS, L.P. (F/K/A CORNELL CAPITAL PARTNERS, L.P.)
Reel/Frame 022542/0001 →
FORECLOSURE BY THIRD PARTY Recorded Apr 6, 2009
From: YA GLOBAL INVESTMENTS, L.P. (F/K/A CORNELL CAPITAL PARTNERS, L.P.)
To: ADVANCED VIRAL RESEARCH CORP.; TRIAD BIOTHERAPEUTICS, INC.
Reel/Frame 022510/0187 →