Endoparasiticidal gel composition
View Patent ↗A homogenous, clear, veterinary gel composition which has a broad spectrum of efficacy against endoparasites over a prolonged period of time and which allows for higher concentrations of a mixture of parasiticidal agents in a single application. This composition is useful for treating and controlling endoparasiticidal infection and infestation in a homeothermic animal.
1. An endoparasiticidal gel composition which comprises: about 1.0% to 3.5% wt/wt of moxidectin; about 10.0% to 15.0% wt/wt of praziquantel; about 4.0% to 24.0% wt/wt of benzyl alcohol; about 1.0% to 34.0% wt/wt of ethanol; about 2.0% to 15.0% wt/wt of colloidal silicon dioxide; about 1.0% to 20.0% wt/wt of a surfactant; and about 35.0% to 61.0% wt/wt of an oil, wherein said composition is an oral gel.
2. The composition according to claim 1 wherein the oil is propylene glycol dicaprylate/dicaprate or dicaprylic/dicapric triglyceride.
3. The composition according to claim 1 wherein moxidectin is present at about 1.5% to 2.5% wt/wt.
4. The composition according to claim 1 wherein praziquantel is present at about 12.0% to 13.0% wt/wt.
5. The composition according to claim 1 wherein benzyl alcohol is present at about 18.0% to 22.0% wt/wt.
6. The composition according to claim 1 wherein ethanol is present at about 5.0% to 7.5% wt/wt.
7. The composition according to claim 5 wherein the surfactant is present at about 3.0% to 6.0%.
8. The composition according to claim 7 wherein the surfactant comprises a polyoxyethylene sorbitan ester.
9. The composition according to claim 8 wherein ethanol is present at about 5.0% to 7.5% wt/wt.
10. The composition according to claim 9 wherein the oil is propylene glycol dicaprylate/dicaprate.
11. The composition according to claim 10 wherein moxidectin is present at about 1.9% to 2.0% wt/wt and praziquantel is present at about 12.0% to 12.5% wt/wt.