Long lasting growth hormone releasing factor derivatives
View Patent ↗This invention relates to growth hormone releasing factor (GRF) derivatives. In particular, this invention relates to GRF peptide derivatives having an extended in vivo half-life, for promoting the endogenous production or release of growth hormone in humans and animals.
1. A growth hormone releasing factor derivative comprising:
Tyr-(D)ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(MPA)—CONH 2 (SEQ ID NO: 6).
2. A conjugate of the following formula:
3. A conjugate of the following formula:
4. A pharmaceutical composition comprising the derivative of claim 1 in combination with a pharmaceutical carrier.
5. The composition of claim 4 for the promotion of endogenous growth hormone production or release in a subject.
6. The composition of claim 4 treating diseases or conditions resulting from growth hormone production abnormalities.
7. A method for treating a disease or condition resulting from a growth hormone production abnormality in a subject, comprising administering to the subject an effective amount of the derivative of claim 1 , alone or in combination with a pharmaceutical carrier.
8. A method of promoting the endogenous production or release of growth hormone in a subject, comprising administering to the subject an effective amount of the derivative of claim 1 , alone or in combination with a pharmaceutical carrier.
9. A method for treating a disease or condition resulting from a growth hormone production abnormality in a subject, comprising administering to the subject an effective amount of the conjugate of claim 3 , alone or in combination with a pharmaceutical carrier.
10. A method of promoting the endogenous production or release of growth hormone in a subject comprising administering to the subject an effective amount of the conjugate of claim 3 , alone or in combination with a pharmaceutical carrier.
11. The method of claim 7 , wherein the subject is a human.
12. The method of claim 8 , wherein the subject is a human.
13. The method of claim 9 , wherein the subject is a human.
14. The method of claim 10 , wherein the subject is a human.
15. The method of claim 7 , wherein the subject is a non-human animal.
16. The method of claim 8 , wherein the subject is a non-human animal.
17. The method of claim 9 , wherein the subject is a non-human animal.
18. The method of claim 10 , wherein the subject is a non-human animal.
19. A pharmaceutical composition comprising the conjugate of claim 2 in combination with a pharmaceutical carrier.
20. A pharmaceutical composition comprising the conjugate of claim 3 in combination with a pharmaceutical carrier.