IP Library › Granted Patent US 7,164,001
Granted Patent B2
US 7,164,001 · App. 10/213,044 · Granted Jan 16, 2007

Compositions and methods for the treatment of immune related diseases

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,164,001
App. No.
10/213,044
Granted
Jan 16, 2007
Kind
B2
Abstract

The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.

Claims (19)

1. An isolated polypeptide having at least 95% amino acid sequence identity to:

(a) the amino acid sequence of the polypeptide shown in FIG. 16 (SEQ ID NO:16);

(b) the amino acid sequence of the polypeptide shown in FIG. 16 (SEQ ID NO:16, lacking its associated signal peptide of amino acids 1–24; or

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-1179;

where the polypeptide of (a), (b), or (c), inhibits the proliferation of T-lymphocytes.

2. The isolated polypeptide of claim 1 having at least 99% amino acid sequence identity to:

(a) the amino acid sequence of the polypeptide shown in FIG. 16 (SEQ ID NO:16);

(b) the amino acid sequence of the polypeptide shown in FIG. 16 (SEQ ID NO:16, lacking its associated signal peptide of amino acids 1–24 or

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-1179;

where the polypeptide of (a), (b), or (c), inhibits the proliferation of T-lymphocytes.

3. A chimeric polypeptide comprising a polypeptide according to claim 1 fused to a heterologous polypeptide.

4. The chimeric polypeptide of claim 3 , wherein said heterologous polypeptide is an epitope tag or an Fc region of an immunoglobulin.

5. An isolated polypeptide comprising:

(a) the amino acid sequence of the polypeptide shown in FIG. 16 (SEQ ID NO:16);

(b) the amino acid sequence of the polypeptide shown in FIG. 16 (SEQ ID NO:16, lacking its associated signal peptide of amino acids 1–24 or

(c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-1179.

6. The isolated polypeptide of claim 5 comprising the amino acid sequence of the polypeptide shown in FIG. 16 (SEQ ID NO:16).

7. The isolated polypeptide of claim 5 comprising the amino acid sequence of the polypeptide shown in FIG. 16 (SEQ ID NO:16), lacking its associated peptide of amino acids 1–24.

8. The isolated polypeptide of claim 5 comprising the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-1179.