IP Library › Granted Patent US 7,262,268
Granted Patent B2
US 7,262,268 · App. 10/213,218 · Granted Aug 28, 2007

Lipopeptide stereoisomers, methods for preparing same, and useful intermediates

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Quick Facts
Patent No.
US 7,262,268
App. No.
10/213,218
Granted
Aug 28, 2007
Kind
B2
Abstract

The present invention provides daptomycin stereoisomeric compounds, methods and intermediates for preparing daptomycin and daptomycin stereoisomoeric compounds, as well as pharmaceutical compositions of these compounds and methods of using these compositions as antibacterial agents.

Claims (8)

1. A composition comprising a compound having the following structure:

where R 5 is an ornithine protecting group and R 6 is hydrido or an asparagine protecting group.

2. The composition of claim 1 , wherein the compound comprises the following stereochemistry:

3. The composition of claim 1 , wherein the compound comprises the following stereochemistry:

4. The composition of any one of claims 1 , 2 , or 3 , wherein R 5 is allyloxycarbonyl, carbobenzyloxycarbonyl or tert-butoxycarbonyl.

5. The composition of claim 4 , wherein R 5 is allyloxycarbonyl.

6. The composition of claim 5 , wherein R 6 is hydrido.

7. A composition comprising a compound having the following structure:

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Jul 24, 2015
From: ROYAL BANK OF CANADA, AS ADMINISTRATIVE AGENT
To: CALIXA THERAPEUTICS, INC.; ADOLOR CORPORATION; CUBIST PHARMACEUTICALS, INC.
Reel/Frame 036180/0070 →
SECURITY AGREEMENT Recorded Nov 20, 2012
From: CUBIST PHARMACEUTICALS, INC.; ADOLOR CORPORATION; CALIXA THERAPEUTICS, INC.; CUBIST PHARMACEUTICALS HOLDINGS, INC.; CUBIST PHARMACEUTICALS U.S.
To: ROYAL BANK OF CANADA, AS ADMINISTRATIVE AGENT
Reel/Frame 029339/0669 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 5, 2003
From: MORYTKO, MICHAEL; ZHANG, YANZHI; JUNG, MICHAEL; FINN, JOHN; BOUCHARD, MARIO
To: CUBIST PHARMACEUTICALS, INC.
Reel/Frame 013707/0373 →