Chroman derivatives as estrogenic compounds
View Patent ↗The invention provides chroman compounds having Formula (1), wherein R 1 is (1C–4C)alkyl, (2C–4C)alkenyl or (2C–4C)alkynyl, and independently R 1 has a cis-orientation in relation to the exocyclic phenyl group at the 2-position of the skeleton; R 4 is Hal, CF 3 , OH or (1C–2C)alkyloxy; R 2 , R 3 , and R 5 are independently H, Hal, CF 3 , (1C–4C)alkyl, (2C–4C)alkenyl or (2C–4C)alkynyl and prodrugs thereof for the manufacture of a medicine for estrogen-receptor related treatments.
1. A chroman compound having formula 1
wherein
R 1 is (1C–4C)alkyl,
wherein R 1 , the exocyclic phenyl group at the 2-position and the exocyclic substituent at the 4-position of the chroman skeleton all have a cis-orientation;
R 2 is H, F or Cl;
R 3 and R 4 are H; and
R 5 is H or CH 3 ;
or a prodrug thereof.
2. The compound according to claim 1 , wherein
R 1 is methyl or ethyl, and
R 5 is H.
3. A pharmaceutical composition, comprising:
a pharmaceutically effective amount of the compound according to claim 1 , and
pharmaceutically acceptable auxiliaries.