Herbal composition PHY906 and its use in chemotherapy
View Patent ↗This invention provides herbal compositions useful for increasing the therapeutic index of drugs, including those used in the treatment of disease, especially viral infections and neoplasms of cancer. This invention provides methods useful for improving the quality of life of an individual undergoing chemotherapy. Furthermore, this invention improves the treatment of disease by increasing the therapeutic index of chemotherapy drugs by administering the herbal composition PHY906 to a person undergoing such chemotherapy.
1. A composition comprising:
i) a pharmaceutically acceptable carrier;
ii) an herbal preparation consisting essentially of Scutellaria, Glycyrrhiza, Ziziphus and Paeonia; and
iii) a chemotherapeutic formulation comprising a chemotherapeutic compound selected from the group consisting of irinotecan (CPT-11). 5-fluorouracil (5-FU), etoposide (VP-16), leucovorin (LV), and beta-1-dioxolane-cytidine (OddC).
2. The composition of claim 1 wherein the herbal preparation consists of Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba, and Paeonia lactiflora.
3. The composition of claim 1 , wherein the chemotherapeutic formulation comprises CPT-11, 5-FU, and LV.
4. A method of treating tumors in a mammal comprising administering a therapeutically effective amount of a composition comprising:
i) a pharmaceutically acceptable carrier;
ii) an herbal preparation cosisting essentially of Scutellaria, Glycyrrhiza, Ziziphus and Paeonia; and
iii) a chemotherapeutic formulation comprising a chemotherapeutic compound selected from the group consisting of CPT-11, 5-FU, VP-16, LV, and OddC.
5. A method of relieving side effects of a chemotherapeutic compound in a mammal comprising administering a composition comprising:
i) a pharmaceutically acceptable carrier;
ii) an herbal preparation consisting essentially of Scutellaria, Glycyrrhiza, Ziziphus and Paeonia; and
iii) the chemotherapeutic formulation comprising the chemotherapeutic compound, wherein the chemotherapeutic compound is selected from the group consisting of CPT-11, 5-FU, VP-16, LV, and OddC.
6. A method of enhancing therapeutic effectiveness of a chemotherapeutic formulation in a mammal comprising administering a composition comprising:
i) a pharmaceutically acceptable carrier;
ii) an herbal preparation consisting essentially of Scutellaria, Glycyrrhiza, Ziziphus and Paeonia; and
iii) the chemotherapeutic formulation comprising a chemotherapeutic compound, wherein the chemotherapeutic compound is selected from the group consisting of CPT-11, 5-FU, VP-16, LV, and OddC.
7. A method of enhancing antitumor activity of a chemotherapeutic compound in a mammal comprising administering a composition comprising:
i) a pharmaceutically acceptable carrier;
ii) an herbal preparation consisting essentially of Scutellaria, Glycyrrhiza, Ziziphus and Paeonia; and
iii) the chemotherapeutic formulation comprising the chemotherapeutic compound, wherein the chemotherapeutic compound is selected from the group consisting of CPT-11, 5-FU, VP-16, LV, and OddC.
8. A method of inhibiting the growth of tumors in a mammal, comprising administering a composition comprising:
i) a pharmaceutically acceptable carrier;
ii) an herbal preparation consisting essentially of Scutellaria, Glycyrrhiza, Ziziphus and Paeonia; and
iii) a chemotherapeutic formulation comprising a chemotherapeutic compound selected from the group consisting of CPT-11, 5-FU, VP-16, LV, and OddC.
9. The method of any one of claims, 4 , 5 , 6 , 7 and 8 wherein the mammal is a human.
10. A method of inhibiting the growth of tumors, comprising administering a composition comprising:
i) a pharmaceutically acceptable carrier;
ii) an herbal preparation consisting essentially of Scutellaria, Glycyrrhiza, Ziziphus and Paeonia; and
iii) a chemotherapeutic formulation comprising a chemotherapeutic compound selected from the group consisting of CPT-11, 5-FU, VP-16, LV, and OddC.
11. The method of claim 10 , wherein the tumors are present in in vitro cells.
12. The method of any one of claims 5 , 6 , 7 , 8 , or 10 , wherein the chemotherapeutic formulation comprises CPT-11, 5-FU, and LV.
13. The method of any one of claims 4 , 5 , 6 , 7 , 8 , and 10 , wherein the herbal preparation consists of Scutellaria baicalensis, Glycyrrhiza uralensis, Ziziphus jujuba, and Paeonia lactiflora.