Monoclonal antibodies to the human LDL receptor, their production and use
View Patent ↗There are provided monoclonal antibodies to the LDL receptor which are useful for the identification and purification of LDL and in treatment of e.g. hepatitis C infection.
1. A monoclonal antibody expressed by hybridoma clone 12.6 deposited at the CNCM under No.1-2390.
2. A monoclonal expressed by hybridoma clone 28 deposited at the CNCM under No. I-2391.
3. A monoclonal antibody expressed by hybridoma clone 29.8 deposited at the CNCM under No. I-2392.
4. A monoclonal antibody expressed by hybridoma clone 30 deposited at the CNCM under No. I-2393.
5. A monoclonal antibody expressed by hybridoma clone 50.30 deposited at the CNCM under No. I-2394.
6. A hybridoma clone 12.6 deposited at the CNCM under No.1-2390.
7. A hybridoma clone 28 deposited at the CNCM under No.1-2391.
8. A hybridoma clone 29.8 deposited at the CNCM under No.1-2392.
9. A hybridoma clone 30 deposited at the CNCM under No.1-2393.
10. A hybridoma clone 50.30 deposited at the CNCM under No. I-2394.
11. A method for purifying human low-density receptor (LDLR) which comprises contacting a material containing crude human LDLR with the monoclonal antibody according to any one of claims 1 - 5 to affinity purify human LDLR.
12. A method for neutralizing an antiviral biological activity of recombinant human soluble low-density lipoprotein receptor (r-hsLDLR) comprising contacting r-hsLDLR with the monoclonal antibody of claim 1 or 5 to neutralize an antiviral biological activity of r-hsLDLR.
13. A method for inhibiting replication of hepatitis C virus, comprising contacting cells with the monoclonal antibody of claim 1 , 2 or 3 prior to infection by hepatitis C virus to inhibit replication of hepatitis C in the cells.