Method for treating a demyelinating condition
View Patent ↗Methods for treating a demyelinating condition in a subject in need of treatment are provided. In some aspects the methods encompass administering to the subject an amount of a Ca 2+ -channel blocker effective to treat the demyelinating condition. In other aspects, the methods encompass administering to the subject an amount of a glutamate inhibitor effective to treat the demyelinating condition. In additional aspects, the methods encompass administering to the subject a Ca 2+ -channel blocker in combination with a glutamate inhibitor, in amounts effective to treat the demyelinating condition. In still other aspects, the methods encompass administering to the subject a Ca 2+ -channel blocker in combination with a hypertensive agent, in amounts effective to treat the demyelinating condition. Also provided are pharmaceutical compositions having a Ca 2+ -channel blocker, a glutamate inhibitor, and a pharmaceutically-acceptable carrier. Additionally, pharmaceutical compositions having a Ca 2+ -channel blocker, a hypertensive agent, and a pharmaceutically-acceptable carrier are provided.
1. A method for treating multiple sclerosis in a subject in need of treatment, the method comprising administering to the subject an amount of a drug effective to treat the multiple sclerosis in the subject, wherein the drug is bepridil or nitrendipine.
2. The method of claim 1 , wherein the drug is bepridil.
3. The method of claim 1 , wherein the drug is nitrendipine.
4. The method of claim 1 , wherein the drug is administered orally.
5. The method of claim 1 , wherein the drug is administered parenterally.
6. The method of claim 1 , wherein the drug is administered by an osmotic mini-pump.