Methods and devices for analysis of x-ray images
View Patent ↗The present invention relates to methods and devices for analyzing x-ray images. In particular, devices, methods and algorithms are provided that allow for the accurate and reliable evaluation of bone structure from x-ray images.
1. A method to derive information on bone structure from image data using a computer system, the method comprising:
(a) deriving quantitative information on bone structure from image data of a subject in a computer system;
(b) comparing the derived information on bone structure to a database of bone structure measurements obtained from selected subjects;
(c) determining a bone condition based at least in part on the comparison; and
(d) reporting the bone condition to a user of the computer system.
2. The method of claim 1 , wherein the image data is x-ray image data.
3. The method of claim 1 , wherein the image data is electronic image data.
4. The method of claim 1 , wherein the image data comprises an external standard.
5. The method of claim 1 , wherein the selected subjects are normal subjects.
6. The method of claim 1 , wherein the selected subjects are osteoporosis subjects.
7. The method of claim 1 , wherein said database comprises demographic data and data on bone structure in the subjects.
8. The method of claim 1 , wherein said subjects are age, sex and race-matched to said subject.
9. A method of diagnosing a bone condition in a subject comprising analyzing information from image data according to the method of claim 1 , wherein if said analysis indicates that the bone structure information obtained from the subject differs from that of normal control subjects, a bone condition is diagnosed.
10. The method of claim 9 , wherein the bone condition is osteoporosis.
11. The method of claim 1 , further comprising the step of locating one or more regions of interest (ROI) in said image data.
12. The method of claim 11 , wherein said ROI is positioned using a regularized active shape algorithm.
13. A method to assess the presence or severity of a bone disease from image data using a computer system, the method comprising:
(a) computing quantitative information on bone structure from image data of a subject;
(b) generating an index of the severity of a bone disease associated with the bone structure based at least in part on the quantitative information;
(c) deriving diagnostic information at least in part from the index; and
(d) reporting the diagnostic information to a user of the computer system.
14. The method of claim 13 , wherein the bone disease is osteoporosis or fracture risk.
15. The method of claim 13 , wherein the image data is x-ray image data.
16. The method of claim 13 , wherein the image data is electronic image data.
17. The method of claim 13 , wherein the image data comprises an external standard.
18. The method of claim 13 , wherein said index is based at least in part on demographic data and data on bone structure in the subjects.
19. The method of claim 13 , further comprising the step of locating one or more regions of interest (ROI) in said image data.
20. The method of claim 19 , wherein said ROI is positioned using a regularized active shape algorithm.