Mutagenic nucleoside analogs for the treatment of viral disease
View Patent ↗The present invention relates to methods of treating viral disease using mutagenic nucleoside analogs. In particular, the invention provides 5-aldehydo-uracil nucleosides and derivatives thereof, and methods of administration thereof to increase the virus mutation rate in a virally infected cell.
1. A method of increasing the mutation rate of an RNA virus, comprising administering a viral mutation inducing amount of a compound to a virally infected cell, wherein the compound has the structure:
wherein,
R 1 is a member from the group consisting of:
R 6 and R 7 are —H;
Y is selected from the group consisting of —H and —OH,
X is selected from the group consisting of —H and —OH,
and at least one but not both of X and Y is —H;
wherein the virus is selected from the group consisting of bovine viral diarrhea virus (BVDV) and measles virus (MV).
2. The method according to claim 1 , wherein the cell is in cell culture.
3. The method according to claim 1 , wherein the cell is in an animal.
4. The method according to claim 1 , wherein the cell is a human cell.
5. The method of claim 1 wherein the RNA virus is measles virus.
6. The method of claim 1 wherein the RNA virus is bovine viral diarrhea virus.