Drug delivery particle
View Patent ↗A drug delivery particle including a reservoir region having primarily large pores and a metering region. The particle can be highly spherical.
1. A drug delivery device comprising:
a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size,
wherein the second predominant pore size is from about 50% to about 70% of the first predominant pore size.
2. The device of claim 1 wherein the polyvinyl alcohol is 1,3 diol acetalized.
3. The device of claim 1 wherein the polyvinyl alcohol is modified by graft polymerization.
4. The device of claim 2 wherein the particle further comprises alginate.
5. The device of claim 1 including a coating of polymer.
6. The device of claim 5 wherein the coating is erodable.
7. The device of claim 5 including a therapeutic agent on the surface of the particle.
8. The device of claim 1 wherein the therapeutic agent is effective for the treatment of cancer.
9. The device of claim 1 wherein the particle has a sphericity of about 80% or more.
10. The device of claim 1 wherein the particle has a diameter of about 1 cm or less.
11. The device of claim 1 comprising a collection of particles.
12. A method of manufacturing a drug delivery particle, the method comprising:
generating drops comprising polyvinyl alcohol and alginate;
forming the drops into particles; and
combining the particles with a therapeutic agent,
wherein each of the particles is a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size.
13. The method of claim 12 , wherein the particles comprise alginate and the method further comprises reacting the polyvinyl alcohol with a cross-linking agent and removing the alginate.
14. The method of claim 13 comprising drying the particle and exposing the dried particle to therapeutic agent.
15. The method of claim 12 comprising combining therapeutic agent prior to generating said drops.
16. The method of claim 12 comprising contacting the drops with a gelling agent.
17. The method of claim 16 wherein the gelling agent is a divalent agent.
18. The method of claim 12 , wherein the particles comprise alginate and the method further comprises reacting the polyvinyl alcohol by acetalization.
19. The method of claim 12 wherein the polyvinyl alcohol has a molecular weight of about 75,000 g/mole or greater.
20. The method of claim 12 comprising modifying the viscosity of the polyvinyl alcohol and alginate prior to forming said drops.
21. The method of claim 20 comprising modifying the viscosity by heating.
22. The method of claim 12 comprising forming said drops by vibratory nebulization.
23. The method of claim 12 wherein the therapeutic agent is an anti-cancer agent.
24. A method of delivering a substantially spherical particle to a patient, the method comprising administering to a patient the substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size.
25. The delivery method of claim 24 wherein the method of administration is by percutaneous injection.
26. The delivery method of claim 24 wherein the method of administration is by a catheter.
27. The delivery method of claim 24 wherein the therapeutic agent is effective for treatment of uterine fibroids.
28. The delivery method of claim 24 wherein the therapeutic agent is effective for treatment of cancerous lesions.
29. The delivery method of claim 27 , wherein the method is used to treat uterine fibroids.
30. The delivery method of claim 28 wherein the method is used to treat a cancerous legion.
31. A method of delivering a therapeutic agent to a patient, the method comprising:
administering to a patient a substantially spherical polymer particle comprising polyvinyl alcohol and having a first region including pores having a first predominant pore size and containing therapeutic agent, and a second region substantially surrounding the first region and including pores having a second predominant pore size, the second predominant pore size being from about 50% to about 70% of the first predominant pore size; and
releasing the therapeutic agent in the patient.