Biocompatible bonding method and electronics package suitable for implantation
View Patent ↗The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package, that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.
1. An implantable device comprising:
a substrate containing at least one electrically conductive feedtbrough attached to an electrically conductive routing on at least one side of said substrate;
a flexible assembly comprised of a first flexible electrically insulating substrate, a second flexible electrically insulating substrate, and at least one bond pad between said first and said second flexible electrically insulating substrates;
said first flexible electrically insulating substrate defining at least one hole that passes through said first flexible electrically insulating substrate, wherein said hole is aligned with said routing;
said second flexible electrically insulating substrate defining at least one hole that passes through said first flexible electrically insulating substrate, wherein said hole is aligned with said routing;
said at least one bond pad defining a hole therethrough, wherein said hole is aligned with said routing; and
wherein said substrate and said flexible assembly are bonded together with a deposited rivet.
2. The implantable device according to claim 1 wherein a biocompatible adhesive bonds said substrate and said flexible assembly.
3. The implantable device according to claim 1 wherein said rivet comprises a biocompatible material.
4. The implantable device according to claim 1 wherein said rivet comprises platinum or a platinum alloy.
5. The implantable device according to claim 1 wherein said deposited rivet is formed by electrochemical deposition.
6. The implantable device according to claim 5 wherein said electrochemical deposition is accomplished at a current density of 50 to 2000 mA/cm 2 .
7. The implantable device according to claim 5 wherein said electrochemical deposition is accomplished by pulse current control.
8. The implantable device according to claim 1 wherein said flexible assembly comprises polyimide.
9. The implantable device according to claim 1 wherein said substrate comprises a biocompatible ceramic.
10. The implantable device according to claim 9 wherein said biocompatible ceramic comprises alumina.
11. The implantable device according to claim 1 wherein said substrate is rigid.
12. The device according to claim 1 wherein said substrate is an electrically insulated integrated circuit.
13. The device according to claim 1 wherein said flexible assembly is a thin integrated circuit.
14. The device according to claim 1 wherein:
at least a part of said substrate forms an electronics control unit; and
said electronics control unit encapsulates electronics.
15. The device according to claim 1 , comprising:
a platinum layer electrochemically deposited on said substrate wherein said layer has a thickness greater than 5 microns and a Vickers hardness greater than 10.
16. The device according to claim 15 , wherein said substrate is platinum.
17. The device according to claim 15 , wherein said platinum layer is fractal.
18. The device according to claim 15 , wherein said platinum layer has a thickness greater than 10 microns.
19. The device according to claim 15 , wherein said platinum layer is biocompatible.
20. The device according to claim 15 , wherein said platinum layer does not contain lead.
21. The device according to claim 15 , wherein said platinum layer consists essentially of pure platinum.
22. The device according to claim 15 , wherein said platinum layer has an adhesive strength, as measured by scratch test, greater than 35 millinewtons critical load.
23. The device according to claim 15 , wherein said platinum layer electrochemically deposited on said substrate is accomplished at a current density that is selected based on a hole diameter defined by said substrate.
24. The device according to claim 15 further comprising:
a first electrically insulating layer deposited on a first side of said substrate; and
a second insulating layer deposited on a second side of said electrically conductive substrate wherein said second insulating layer defines a hole wherein said platinum layer is electrochemically deposited.
25. The device according to claim 15 , wherein said device is suitable for implantation within a living body.
26. The device according to claim 15 , wherein said device forms an electrode.
27. A method of making a device, according to claim 1 comprising:
said substrate at least a portion of which is electrically conductive; and
electrochemically depositing a layer of platinum greater than one micron thick, with a Vickers hardness greater then ten on said electrically conductive portion.
28. The method of claim 27 further comprising the step of selecting a charge density for electrochemically depositing that is proportional to the area of said electrically conductive portion.
29. The method of claim 27 wherein said electrochemically deposited layer is greater then ten microns thick.
30. The method of claim 27 wherein said step of electrochemically depositing uses a current density, in milliamps per square centimeter, equal to 19572x −1.46 , where x is the diameter in microns of said electrically conductive portion of said substrate.
31. The method according to claim 27 of electrochemically depositing a platinum layer, comprising:
electroplating the surface of a conductive substrate at a rate such that the particles of platinum form on the conductive substrate faster than necessary to form shiny platinum and slower than necessary to form platinum gray;
aligning an anode and a cathode;
immersing said anode and cathode in an electrochemical bath; and
plating said platinum layer.