Protease inhibitors
View Patent ↗The present invention provides C 1-6 alkyl-4-amino-azepan-3-one protease inhibitors and pharmaceutically acceptable salts, hydrates and solvates thereof which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, novel intermediates of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia of malignancy; and metabolic bone disease; and parasitic diseases, including malaria, by administering to a patient in need thereof one or more compounds of the present invention.
1. A compound which is benzofuran-2-carboxylic acid {(S)-3-methyl-1-[(4S, 7R)-7-methyl-3-oxo-1-(pyridine-2-sulfonyl)-azepan-4-ylcarbamoyl]-butyl}-amide.
2. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier, diluent or excipient.
3. A method of treating osteoporosis by administering to a patient in need thereof an effective amount of a compound according to claim 1 .
4. A method of treating periodontitis by administering to a patient in need thereof an effective amount of a compound according to claim 1 .
5. A method of treating gingivitis by administering to a patient in need thereof an effective amount of a compound according to claim 1 .
6. A method of treating osteoarthritis by administering to a patient in need thereof an effective amount of a compound according to claim 1 .
7. A method of treating rheumatoid arthritis by administering to a patient in need thereof an effective amount of a compound according to claim 1 .