IP Library › Patent Application 10247015
Patent Application
App. No. 10/247,015

Secreted and transmembrane polypeptides and nucleic acids encoding the same

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
10/247,015
Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Claims (70)

1 - 28 . (canceled)

29 . An isolated nucleic acid having at least 80% nucleic acid sequence identity to:

(a) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(b) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(e) the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97);

(f) the full-length coding sequence of the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97); or

(g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-2823.

30 . The isolated nucleic acid of claim 29 having at least 85% nucleic acid sequence identity to:

(a) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(b) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(e) the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97);

(f) the full-length coding sequence of the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97); or

(g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-2823.

31 . The isolated nucleic acid of claim 29 having at least 90% nucleic acid sequence identity to:

(a) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(b) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(e) the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97);

(f) the full-length coding sequence of the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97); or

(g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-2823.

32 . The isolated nucleic acid of claim 29 having at least 95% nucleic acid sequence identity to:

(a) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(b) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(e) the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97);

(f) the full-length coding sequence of the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97); or

(g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-2823.

33 . The isolated nucleic acid of claim 29 having at least 99% nucleic acid sequence identity to:

(a) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(b) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(e) the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97);

(f) the full-length coding sequence of the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97); or

(g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-2823.

34 . An isolated nucleic acid comprising:

(a) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(b) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(e) the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97);

(f) the full-length coding sequence of the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97); or

(g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-2823.

35 . The isolated nucleic acid of claim 34 comprising a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98).

36 . The isolated nucleic acid of claim 34 comprising a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide.

37 . The isolated nucleic acid of claim 34 comprising a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98).

38 . The isolated nucleic acid of claim 34 comprising a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide.

39 . The isolated nucleic acid of claim 34 comprising the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97).

40 . The isolated nucleic acid of claim 34 comprising the full-length coding sequence of the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97).

41 . The isolated nucleic acid of claim 34 comprising the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-2823.

42 . An isolated nucleic acid that hybridizes to:

(a) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(b) a nucleic acid sequence encoding the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(c) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98);

(d) a nucleic acid sequence encoding the extracellular domain of the polypeptide shown in FIG. 98 (SEQ ID NO:98), lacking its associated signal peptide;

(e) the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97);

(f) the full-length coding sequence of the nucleic acid sequence shown in FIG. 97 (SEQ ID NO:97); or

(g) the full-length coding sequence of the cDNA deposited under ATCC accession number PTA-2823.

43 . The isolated nucleic acid of claim 42 , wherein said hybridization occurs under stringent conditions.

44 . The isolated nucleic acid of claim 42 which is at least 10 nucleotides in length.

45 . A vector comprising the nucleic acid of claim 29 .

46 . The vector of claim 45 , wherein said nucleic acid is operably linked to control sequences recognized by a host cell transformed with the vector.

47 . A host cell comprising the vector of claim 45 .

48 . The host cell of claim 47 , wherein said cell is a CHO cell, an E. coli or a yeast cell.