Process for preparing a creatine heterocyclic acid salt and method of use
View Patent ↗This invention relates to a process for the synthesis and method of use of an effective amount of a creatine heterocyclic acid salt for the regulation athletic function in humans.
1. A process for the synthesis of creatine orotic acid, thioorotic acid, and dihydroorotic acid salt comprising the steps of:
a) mixing creatine with water appetent organic alcohol solvents, other water appetent organic solvents, or water at a temperature of 1 to 100 degree Celsius,
b) reacting the product of step a) with orotic acid, thioorotic acid, or dihydroorotic acid at a temperature of 1 to 100 degree Celsius;
C) filtering to remove the solvent and washing the residue with water appetent organic alcohol solvents, other water appetent organic solvents, or water for the recovery of a mono, di, or tricreatine orotic acid, thioorotic acid, and dihydroorotic acid salt.
2. The process according to claim 1 step a), wherein the reaction is carried out at a temperature under 22 degree Celsius.
3. The process according to claim 1 step a), wherein said creatine is creatine monohydrate and said water appetent organic alcohol solvent is selected from the group consisting of methanol, ethanol, or propanol.
4. The process according to claim 1 step b), wherein the reaction is carried out at a temperature under 22 degree Celsius.
5. The process according to claim 1 step c), wherein the said water appetent organic alcohol solvent is selected from the group consisting of methanol, ethanol, and propanol.
6. A method for providing creatine to a human, comprising: receiving a creatine orotic acid, thioorotic acid, and dihydroorotic acid salt by the human, wherein the creatine orotic acid, thioorotic acid, and dihydroorotic acid salt is suitable for being modified by the human to form creatine.
7. The method as described in claim 6 , wherein the creatine orotic acid, thioorotic acid, and dihydroorotic acid salt is suitable for peroral, transdermal, sublingual, and intranasal administration.
8. The method as described in claim 6 , wherein the creatine orotic acid, thioorotic acid, and dihydroorotic acid salt is suitable in a daily dose of 1 to 40,000 mg/day.
9. The method as described in claim 6 , wherein the creatine orotic acid, thioorotic acid, and dihydroorotic acid salt is received by the human, the creatine orotic acid, thioorotic acid, and dihydroorotic acid salt is modified by the human into creatine and orotic acid, thioorotic acid, and dihydroorotic acid.