Preventives or remedies for arthritis
View Patent ↗The present invention relates to pharmaceuticals, foods and drinks, food additives, animal feeds and feed additives comprising an N-acylated hydroxyproline derivative or a salt thereof, and an amino sugar or a salt thereof and/or a glycosaminoglycan or a salt thereof as active ingredients, use of an Nacylated hydroxyproline derivative or a salt thereof for the production of an arthritis preventing or treating agent, and a method for preventing or treating arthritis which comprises administering an N-acylated hydroxyproline derivative or a salt thereof, and an amino sugar or a salt thereof and/or a glycosaminoglycan or a salt thereof.
1. A pharmaceutical composition which comprises an N-acylated hydroxyproline derivative or a salt thereof, an amino sugar or a salt thereof, and a glycosaminoglycan or a salt thereof.
2. The pharmaceutical composition according to claim 1 , wherein said hydroxyproline is selected from the group consisting of cis-4-hydroxy-L-proline, cis-4-hydroxy-D-proline, cis-3-hydroxy-L-proline, cis-3-hydroxy-D-proline, trans-4-hydroxy-L-proline, trans-4-hydroxy-D-proline, trans-3-hydroxy-L-proline and trans-3-hydroxy-D-proline.
3. The pharmaceutical composition according to claim 1 or 2 , wherein the acyl moiety of said N-acylated hydroxyproline derivative is an acyl group having 2–23 carbon atoms.
4. The pharmaceutical composition according to claim 3 , wherein said N-acylated hydroxyproline derivative is N-acetylhydroxyproline.
5. The pharmaceutical composition according to claim 4 , wherein said amino sugar is glucosamine or a salt thereof.
6. The pharmaceutical composition according to claim 5 , comprising said glycosaminoglycan or salt thereof, wherein said glycosaminoglycan is chondroitin sulfate or a salt thereof.
7. A method for treating arthritis, comprising administering the pharmaceutical composition according to claim 6 to a patient in need thereof.
8. The method according to claim 7 , wherein said arthritis is rheumatoid arthritis.
9. A food, drink or an animal feed which comprises an N-acylated hydroxyproline derivative or a salt thereof, an amino sugar or a salt thereof, and a glycosaminoglycan or a salt thereof.
10. The food, drink or the animal feed according to claim 9 , wherein said hydroxyproline is selected from the group consisting of cis-4-hydroxy-L-proline, cis-4-hydroxy-D-proline, cis-3-hydroxy-L-proline, cis-3-hydroxy-D-proline, trans-4-hydroxy-L-proline, trans-4-hydroxy-D-proline, trans-3-hydroxy-L-proline and trans-3-hydroxy-D-proline.
11. The food, drink or the animal feed according to claim 9 or 10 , wherein the acyl moiety of said N-acylated hydroxyproline derivative is an acyl group having 2–23 carbon atoms.
12. The food, drink or the animal feed according to claim 11 , wherein said N-acylated hydroxyproline derivative is N-acetylhydroxyproline.
13. The food, drink or the animal feed according to claim 12 , wherein said amino sugar is glucosamine or a salt thereof.
14. The food, drink or the animal feed according to claim 13 , wherein said glycosaminoglycan is chondroitin sulfate or a salt thereof.
15. A method for treating arthritis in mammals, which comprises administering a composition comprising (I) and (II):
(I) an-N-acylated hydroxyproline derivative or a salt thereof,
(II) at least one of
(i) an amino sugar or a salt thereof, and
(ii) a glycosaminoglycan or a salt thereof
to a patient in need thereof.
16. The method according to claim 15 wherein the patient is a human.
17. The method according to claim 15 or 16 wherein said composition is administered orally.
18. The method according to claim 15 or 16 , wherein said composition comprises both (i) said amino sugar or salt thereof and (ii) said glycosaminoglycan or salt thereof.
19. The method according to claim 17 , wherein said composition comprises both (i) said amino sugar or salt thereof and (ii) said glycosaminoglycan or salt thereof.