Peptide compounds

1. A compound of the formula (I):

wherein

R 1 is benzofuranyl substituted by halogen, or styryl substituted by halogen;

R 2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and

X is

or pharmaceutically acceptable salts thereof.

2. The compound of claim 1 , wherein R 2 is a group of the formula:

—Y—R 3 wherein R 3 is lower alkyl, halo(lower)alkyl, optionally substituted heterocyclic group or optionally substituted aryl, and Y is —O—, —S— or —SO 2 —, or a pharmaceutically acceptable salt thereof.

3. The compound of claim 2 , wherein R 3 is lower alkyl; halo(lower)alkyl; heterocyclic group optionally substituted by one or more substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, halogen and halo(lower)alkyl; or aryl optionally substituted by one or more substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, halogen and halo(lower)alkyl, or a pharmaceutically acceptable salt thereof.

4. The compound of claim 3 , wherein R 3 is lower alkyl; halo(lower)alkyl; heterocyclic group selected from the group consisting of pyridyl, pyrazinyl, thiazolyl, pyridazinyl and pyrimidinyl, said heterocyclic group is optionally substituted by one or more substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, halogen and halo(lower)alkyl; or phenyl optionally substituted by one or more substituent(s) selected from the group consisting of lower alkyl, lower alkoxy, halogen and halo(lower)alkyl, or a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 , wherein X is

or a pharmaceutically acceptable salt thereof.

6. The compound of claim 5 , wherein R 2 is substituted hydroxy, or or a pharmaceutically acceptable salt thereof.

7. The compound of claim 6 , wherein R 2 is a group of the formula:

—O—R 3 wherein R 3 is lower alkyl, halo(lower)alkyl, optionally substituted heterocyclic group or optionally substituted aryl, or a pharmaceutically acceptable salt thereof.

8. The compound of claim 7 , wherein R 3 is lower alkyl, halo(lower)alkyl, pyridyl, pyrazinyl, thiazolyl or phenyl, each of said pyridyl, pyrazinyl, thiazolyl and phenyl is optionally substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen and halo(lower)alkyl, or a pharmaceutically acceptable salt thereof.

9. The compound of claim 8 , wherein R 3 is lower alkyl, halo(lower)alkyl, pyridyl, pyrazinyl, thiazolyl or phenyl, said pyridyl is optionally substituted by a substituent selected from the group consisting of lower alkyl, lower alkoxy, halogen and halo(lower)alkyl, or a pharmaceutically acceptable salt thereof.

10. The compound of claim 1 , wherein R 1 is benzofuranyl substituted by chlorine, or styryl substituted by chlorine, or a pharmaceutically acceptable salt thereof.

11. The compound of claim 1 , wherein R 1 is 5-chloro-1-benzofuran-2-yl or 2-(4-chlorophenyl)ethenyl, or a pharmaceutically acceptable salt thereof.

12. The compound of claim 1 , which is selected from the group consisting of:

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(1,3-thiazol-2-yloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(1,3-thiazol-2-yloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyrazinyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyrazinyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(4-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(4-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl)}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-methoxy-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1 S)-2-[(2-{4-[(6-methoxy-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{3-[(5-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-[(2-{3-[(5-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-methyl-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5 -Chloro-N-[(1S)-2-[(2-{4-[(6-methyl-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[5-(trifluoromethyl)-2-pyridyl]oxy}-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[5-(trifluoromethyl)-2-pyridyl]oxy}-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(5-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(5-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-phenoxy-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-phenoxy-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2,2,2-trifluoroethoxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2,2,2-trifluoroethoxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridytmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-{[2-(4-isopropoxy-1-piperidinyl)-2-oxoethyl]amino}-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-{[2-(4-isopropoxy-1 -piperidinyl)-2-oxoethyl]amino}-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-N-[(1S)-2-{[2-(4-Butoxy-1-piperidinyl)-2-oxoethyl]amino}-2-oxo-1-(2-pyridylmethyl)ethyl]-3 -(4-chlorophenyl)acrylamide;

N-[(1S)-2-{[2-(4-Butoxy-1-piperidinyl)-2-oxoethyl]amino}-2-oxo-1-(2-pyridylmethyl)ethyl]-5-chloro-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-chloro-2-pyrazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-chloro-2-pyrazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofaran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-chloro-3-pyridazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-chloro-3-pyridazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-methoxy-3-pyridazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-methoxy-3-pyridazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(3-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(3-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-chloro-4-pyrimidinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-chloro-4-pyrimidinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[6-(trifluoromethyl)-4-pyrimidinyl]oxy}-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[6-(trifluoromethyl)-4-pyrimidinyl]oxy}-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

5-Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[2-(trifluoromethyl)-4-pyrimidinyl]oxy}-1-piperidinyl)ethyl]amino }-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(5-chloro-2-pyrazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(5-methyl-1,3-thiazol-2-yl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(5-methyl-1,3 -thiazol-2-yl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(5-chloro-1,3 -thiazol-2-yl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(5-chloro-1,3-thiazol-2-yl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{(3R)-3-[(5 -chloro-2-pyridyl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{(3R)-3-[(5-chloro-2-pyridyl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{(3S)-3-[(5-chloro-2-pyridyl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-[(2-{(3S)-3-[(5-chloro-2-pyridyl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{(3R)-3-[(6-chloro-2-pyrazinyl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{(3R)-3-[(6-chloro-2-pyrazinyl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{(3R)-3-[(5-methyl-1,3-thiazol-2-yl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{(3R)-3-[(5-methyl-1,3-thiazol-2-yl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(3-{[6-(trifluoromethyl)-4-pyrimidinyl]oxy}-1-azetidinyl)ethyl]amino }-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[6-(tnfluoromethyl)-4-pyrimidinyl]oxy}-1-azetidinyl)ethyl]amino }-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(3,5-dichloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-[(2-{4-[(3,5-dichloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[3-(trifluoromethyl)-2-pyridyl]oxy}-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[3-(trifluoromethyl)-2-pyridyl]oxy}-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]-1-benzofiiran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-({2-[4-(4-fluorophenoxy)-1-piperidinyl]-2-oxoethyl}amino)-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-({2-[4-(4-fluorophenoxy)-1-piperidinyl]-2-oxoethyl}amino)-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-[(2-oxo-2-{4-[4-(trifloromethyl)phenoxy]-1-piperidinyl}ethyl)amino]-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-oxo-2-[(2-oxo-2-{4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl}ethyl)amino]-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-({2-[4-(4-chlorophenoxy)-1-piperidinyl]-2-oxoethyl}amino)-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-({2-[4-(4-chlorophenoxy)-1-piperidinyl]-2-oxoethyl}amino)-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridylthio)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridylthio)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridylsulfonyl)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridylsulfonyl)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(5 -chloro-2-pyridyl)thio]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(5-chloro-2-pyridyl)thio]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(4-pyridylthio)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(4-pyridylthio)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(4-chlorophenyl)thio]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(4-chlorophenyl)thio]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(4-chlorophenyl)sulfonyl]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(4-chlorophenyl)sulfonyl]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide; and

pharmaceutically acceptable salts thereof.

13. The compound of claim 1 , which is selected from the group consisting of:

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(1,3-thiazol-2-yloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyrazinyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-methoxy-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-phenoxy-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2,2,2-trifluoroethoxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-{[2-(4-isopropoxy-1-piperidinyl)-2-oxoethyl]amino }-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide; and

pharmaceutically acceptable salts thereof.

14. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable carrier.

15. A pharmaceutical composition comprising FK506 and a compound of claim 1 or a pharmaceutically acceptable salt thereof.

16. The pharmaceutical composition of claim 14 , which comprises a compound selected from the group consisting of:

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(1,3-thiazol-2-yloxy)-1-piperidinyl]ethyl }amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(1,3-thiazol-2-yloxy)-1-piperidinyl]ethyl }amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyrazinyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyrazinyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(4-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(4-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-pipendinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-methoxy-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-methoxy-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{3-[(5-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-[(2-{3-[(5-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridytmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-methyl-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-methyl-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[5-(trifluoromethyl)-2-pyridyl]oxy}-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[5-(trifluoromethyl)-2-pyridyl]oxy}-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(5 -chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(5-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-phenoxy-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-phenoxy-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2,2,2-trifluoroethoxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2,2,2-trifluoroethoxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-{[2-(4-isopropoxy-1-piperidinyl)-2-oxoethyl]amino }-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide;

5-Chloro-N-[(1S)-2-{[2-(4-isopropoxy-1-piperidinyl)-2-oxoethyl]amino}-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-N-[(1S)-2-{[2-(4-Butoxy-1-piperidinyl)-2-oxoethyl]amino }-2-oxo-1-(2-pyridylmethyl)ethyl]-3-(4-chlorophenyl)acrylamide;

N-[(1S)-2-{[2-(4-Butoxy-1-piperidinyl)-2-oxoethyl]amino}-2-oxo-1-(2-pyridylmethyl)ethyl]-5-chloro-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-chloro-2-pyrazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-chloro-2-pyrazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-chloro-3-pyridazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-[(2-{4-[(6-chloro-3-pyridazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-methoxy-3-pyridazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-methoxy-3-pyridazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(3-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(3-chloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(6-chloro-4-pyrimidinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(6-chloro-4-pyrimidinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[6-(trifluoromethyl)-4-pyrimidinyl]oxy}-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[6-(trifluoromethyl)-4-pyrimidinyl]oxy}-1-piperidinyl)ethyl]amino }-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

5-Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[2-(trifluoromethyl)-4-pyrimidinyl]oxy}-1-piperidinyl)ethyl]amino }-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(5 -chloro-2-pyrazinyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(5-methyl-1,3-thiazol-2-yl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(5-methyl-1,3-thiazol-2-yl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(5-chloro-1,3-thiazol-2-yl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(5-chloro-1,3-thiazol-2-yl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{(3R)-3-[(5-chloro-2-pyridyl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{(3R)-3-[(5-chloro-2-pyridyl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{(3S)-3-[(5-chloro-2-pyridyl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{(3S)-3-[(5-chloro-2-pyridyl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{(3R)-3-[(6-chloro-2-pyrazinyl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{(3R)-3-[(6-chloro-2-pyrazinyl)oxy]-1-pyrrolidinyl }-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{(3R)-3-[(5-methyl-1,3-thiazol-2-yl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{(3R)-3-[(5 -methyl-1,3-thiazol-2-yl)oxy]-1-pyrrolidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(3-{[6-(trifluoromethyl)-4-pyrimidinyl]oxy}-1-azetidinyl)ethyl]amino }-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[6-(trifluoromethyl)-4-pyrimidinyl]oxy}-1-azetidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(3,5-dichloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-[(2-{4-[(3,5-dichloro-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[3-(trifluoromethyl)-2-pyridyl]oxy}-1-piperidinyl)ethyl]amino }-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-{[3-(trifluoromethyl)-2-pyridyl]oxy}-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-({2-[4-(4-fluorophenoxy)-1-piperidinyl]-2-oxoethyl}amino)-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-({2-[4-(4-fluorophenoxy)-1-piperidinyl]-2-oxoethyl}amino)-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-[(2-oxo-2-{4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl}ethyl)amino]-1-(2-pyridylrnethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-oxo-2-[(2-oxo-2-{4-[4-(trifluoromethyl)phenoxy]-1-piperidinyl}ethyl)amino]-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-({2-[4-(4-chlorophenoxy)-1-piperidinyl]-2-oxoethyl}amino)-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-({2-[4-(4-chlorophenoxy)-1-piperidinyl]-2-oxoethyl}amino)-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridylthio)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridylthio)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridylsulfonyl)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridylsulfonyl)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(5-chloro-2-pyridyl)thio]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5 -Chloro-N-[(1S)-2-[(2-{4-[(5 -chloro-2-pyridyl)thio]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(4-pyridylthio)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(4-pyridylthio)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(4-chlorophenyl)thio]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(4-chlorophenyl)thio]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-[(2-{4-[(4-chlorophenyl)sulfonyl]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-2-propenamide;

5-Chloro-N-[(1S)-2-[(2-{4-[(4-chlorophenyl)sulfonyl]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide; and

pharmaceutically acceptable salts thereof.

17. The pharmaceutical composition of claim 14 , which comprises a compound selected from the group consisting of:

5-Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(1,3-thiazol-2-yloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyrazinyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]acrylamide;

5 -Chloro-N-[(1S)-2-[(2-{4-[(6-methoxy-2-pyridyl)oxy]-1-piperidinyl}-2-oxoethyl)amino]-2-oxo-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

5 -Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofiiran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-{[2-oxo-2-(4-phenoxy-1-piperidinyl)ethyl]amino}-1-(2-pyridylmethyl)ethyl]acrylamide;

5 -Chloro-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(2,2,2-trifluoroethoxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-1-benzofuran-2-carboxamide;

(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-{[2-(4-isopropoxy-1-piperidinyl)-2-oxoethyl]amino }-2-oxo-1-(2-pyridylmethyl)ethyl]acrylamide; and

pharmaceutically acceptable salts thereof.

18. A method of treating rejection due to organ transplantation by administering an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof, to a subject in need thereof.

19. A method of treating rejection due to organ transplantation by administering an effective amount of a pharmaceutical composition comprising FK506 and a compound of claim 1 or a pharmaceutically acceptable salt thereof, to a subject in need thereof.