Uses for polycationic compounds
View Patent ↗The invention relates to the use of a polycationic compound for the preparation of a medicament with retarded in vivo release.
1. A method of vaccinating comprising administering to a subject at a subcutaneous, intradermal, transdermal, or intramuscular site of administration polyarginine, and an antigenic polypeptide consisting of a T cell epitope of 8 to 11 amino acids in length, and an immunogenic nucleic acid molecule, wherein a depot effect is induced at the site of administration wherein the depot effect is present at the site of administration 19 days after administration.
2. The method of claim 1 , wherein the immunogenic nucleic acid molecule is an oligonucleotide containing non-methylated cytosine-guanine dinucleotides( CpG-ODN) or an inosine containing oligodeoxynucleotide (I-ODN).
3. A method of vaccinating comprising injecting into a subject at a subcutaneous, intradermal, transdermal, or intramuscular site of administration polyarginine, and an antigenic polypeptide consisting of a T cell epitope of 8 to 11 amino acids in length, and an immunogenic nucleic acid molecule, wherein a depot effect is induced at the site of administration wherein the depot effect is present at the site of administration 19 days after administration.
4. The method of claim 3 , wherein the immunogenic nucleic acid molecule is an oligonucleotide containing non-methylated cytosine-guanine dinucleotides (CpG-ODN) or an inosine containing oligodeoxynucleotide (I-ODN).