Self-curing system for endodontic sealant applications
View Patent ↗A two-part self-curing endodontic sealing system comprises a thiourea derivative, such as acetyl thiourea, and a hydroperoxide, such as cumene hydroperoxide. The thiourea derivative is used as a reducing agent and the hydroperoxide is used as an oxidizing agent.
1. A method of sealing a root canal during an endodontic procedure using a sealing composition comprising:
mixing a first part of the sealing composition comprising a hydroperoxide oxidizing agent in an amount from about 1% to 3% by weight with a second part of the sealing composition comprising a thiourea reducing agent in an amount from about 1% to 3% by weight, wherein the second part further comprises an acidic component, wherein a polymerizable resin is contained in at least the first part or the second part of the sealing composition, wherein the sealing composition comprises a basic filler consisting essentially of calcium hydroxide; and wherein the sealing composition is shelf-life stable at 50° C. for about four weeks; and
inserting the sealing composition into the root canal.
2. The method of claim 1 wherein the acidic component comprises an organic acid miscible in the polymerizable resin.
3. The method of claim 2 wherein the organic acid comprises an acid having a carboxylic or phosphoric acid group attached.
4. The method of claim 2 wherein the organic acid comprises methacrylic acid, pyromellitic dianhydrate glyceryl dimethacrylate (PMGDM), or 4-methacryloxyethyl trimellitic anhydride (4-META).