Indole derivatives as anti-inflammatory agents
This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: wherein A is a —CH 2 —, —O—, —S—, or —S(O)—; and the other substituents are as defined in the specification; or individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
1. A compound selected from the group of compounds represented by Formula I:
wherein:
A is a —O—, —S—, or —S(O);
Ar is an optionally substituted phenyl;
R 1 is cyano;
R 2 is hydrogen, alkyl, alkoxy, hydroxy, halo, haloalkyl, nitro, cyano, or —NR 5 R 6 , wherein R 5 and R 6 are each independently in each occurrence hydrogen or alkyl;
R 3 is —SOR 7 , or —SO 2 R 7 , or wherein R 7 is alkyl; and R 5 and R 6 are as defined previously;
R 4 is hydrogen or alkyl;
or pharmaceutically acceptable salts.
2. The compound of claim 1 wherein Ar is phenyl optionally substituted at one or two substituents independently selected from the group consisting of halo and alkoxy, and R 3 is —SO 2 R 7 .
3. The compound of claim 2 wherein A is —S.
4. The compound of claim 1 comprising:
3-(4-Fluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carbonitrile; or
3-(2,4-Difluoro-phenylsulfanyl)-6-methanesulfonyl-1H-indole-2-carbonitrile.
5. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable excipient.