Method for enhancing protective cellular responses to genotoxic stress in skin

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Quick Facts

Patent No.: US 7,425,319
App. No.: 10/256,403
Granted: Sep 16, 2008
Kind: B2

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Abstract

The present invention is directed to methods of using pro-NAD agents capable of enhancing the dermal and epidermal skin cell NAD content. These pro-NAD agents may be administered topically, orally, or parenterally to enhance DNA repair and other protective responses to DNA damage. The invention further relates to pharmaceutical compositions comprising pro-NAD agents that effectively elevate intracellular NAD content. Finally, the invention relates to the method of using the pro-NAD agents to treat disorders such as sunburn and other skin deterioration that results from DNA damage in skin cells.

Claims (16)

1. A composition for increasing intracellular NAD content, comprising a hexadecyl nicotinic acid ester, tocopheryl acetate and a pharmaceutically acceptable carrier.

2. The composition of claim 1 , wherein said hexadecyl nicotinic acid ester is presented in said composition at from about 0.001% to about 10% by weight of said composition.

3. The composition of claim 2 , wherein said hexadecyl nicotinic acid ester is present in said composition at from about 0.01% to about 3% by weight of said composition.

4. The composition of claim 3 , wherein said hexadecyl nicotinic acid ester is present in said composition at about 1% by weight of said composition.

5. A composition for increasing intracellular NAD content comprising:

(i) a hexadecyl nicotinic acid ester;

(ii) an antioxidant, a sun screen, a vitamin or a pH stabilizer;

(iii) tocopheryl acetate, and

(iv) a pharmaceutically acceptable carrier.

6. The composition of claim 5 , wherein (ii) is an antioxidant.

7. The composition of claim 5 , wherein (ii) is a sun screen.

8. The composition of claim 5 , wherein (ii) is a vitamin.

9. The composition of claim 5 , wherein (ii) is a pH stabilizer.

10. The composition of claim 5 , wherein (i) is present at from about 0.001% to about 10% by weight of said composition.

11. The composition of claim 10 , wherein (i) is present at from about 0.01% to about 3% by weight of said composition.