Medical devices comprising nanocomposites
View Patent ↗The present invention provides medical devices comprising nanocomposite materials. By utilizing nanocomposites in the production thereof, the inventive medical devices can be produced with various advantageous properties. Methods of producing the inventive medical devices are also provided. Inasmuch as the inventive devices are expected to provide certain advantages in their use, there is also provide a method of medical care including methods of treatment or diagnosis, wherein the inventive devices are brought into therapeutic contact with a body to be treated or diagnosed thereby.
1. A medical device comprising:
at least one component comprising multiple layers, at least one of the layers comprising a nanocomposite material comprising
a matrix material, and
a plurality of nanoparticulate filler particles comprising one or more polyhedral oligomeric silsesquioxane and one or more carbon or ceramic nanotubes, nanowires or nanofibers,
wherein the matrix material comprises a nitrile butadiene elastomer, a silicone, an epoxy, a isocyanate, EPDM, epichlorohydrin, or a copolymer, block copolymer or polymer blend of these; or
a polyamide, a polyester, a polyether, a polyurethane, a polyurea, a polyacrylic, a fluoropolymer or a copolymer, block copolymer or blend of any of these.
2. The medical device of claim 1 , wherein the nanocomposite material further comprises a funcrionalizer, a compatibilizer, a dispersant or combinations thereof.
3. The medical device of claim 1 , wherein the device is a transluminal medical device.
4. The medical device of claim 3 , wherein the at least one component comprises an inner lumen wall of a multilumen catheter.
5. The medical device of claim 3 , wherein the at least one component comprises an outer lumen wall of a multilumen catheter.
6. The medical device of claim 3 , wherein the at least one of the layers is tapered in thickness along a longitudinal axis thereof.
7. The medical device of claim 3 , wherein flexibility of the device varies along a longitudinal axis thereof.
8. The medical device of claim 3 , wherein the component comprises at least one nanocomposite layer and at least one layer.
9. The medical device of claim 3 , wherein the component comprises at least two nanocomposite layers separated by at least one non-nanocomposite layer.
10. The medical device of claim 3 , wherein the component comprises at least a first and a second nanocomposite layer, wherein the first and second nanocomposite layers are comprised of different nanocomposites.
11. The medical device of claim 3 , wherein the component comprises at least a first ,and a second nanocomposite layer, wherein at least one of the first and second nanocomposite layers further comprises at least a first functionalizer, and are otherwise comprised of the same nanocomposite.
12. The medical device of claim 3 , wherein the component comprises at least a first and a second nanocomposite layer, wherein the first and second nanocomposite layers further comprise at least a first and a second functionalizer respectively, and otherwise are comprised of the same nanocomposite.
13. The medical device of claim 1 , wherein the at least one component comprises an expandable balloon.
14. The medical device of claim 13 , wherein each of at least two layers comprises a different functionalizer and are otherwise comprised of the same nanocomposite material.
15. The medical device of claim 1 , wherein the matrix material comprises a thermoset material.
16. The medical device of claim 1 , wherein the matrix material comprises a thermoplastic material.
17. The medical device of claim 16 , wherein the thermoplastic material is a nylon.
18. The medical device of claim 17 , wherein the nylon is nylon 12.
19. The medical device of claim 16 , wherein the thermoplastic material is a polyether amide block copolymer.
20. The medical device of claim 1 , wherein the filler particles further comprise synthetic or natural phyllosilicate, monomeric silicate, metal or metal oxide powder, magnetic or paramagnetic powder, temperature sensitive polymer, biodegradable polymer or a combination of these.
21. The medical device of claim 1 , wherein the filler particles further comprise one or more phyllosilicates.
22. The medical device of claim 1 , wherein the filler particles further comprise one or more clays.
23. The medical device of claim 22 , wherein at least one of the clays comprises montmorillonite.
24. The medical device of claim 1 , wherein the at least one component comprises a catheter shaft.
25. The medical device of claim 1 , wherein the at least one component comprises a stent.
26. The medical device of claim 1 , wherein the medical device is a guide catheter.
27. The medical device of claim 1 , wherein the at least one component comprises a stent delivery catheter.