Polynucleotides encoding a super-active porcine growth hormone releasing hormone analog
View Patent ↗Inadequate growth due to deficiencies in growth hormone (GR), growth hormone releasing hormone (GHRH), or genetic diseases can be ameliorated utilizing recombinant protein therapy with a novel GHRH analog having a sequence (SEQ ID NO:1). Also included is (1) a method of treating growth hormone-related deficiencies associated with the growth hormone pathway; (2) a method for treating growth hormone-related deficiencies associated with genetic disease; (3) a method to improve growth performance in an animal; (4) a method of treating an animal having a growth deficiency disease; (5) a method of increasing the efficiency of an animal used for food; and (6) a method to enhance growth in an animal.
1. An isolated polynucleotide molecule encoding a growth hormone-releasing hormone having the amino acid sequence of SEQ ID NO:1.
2. A vector comprising a promoter; a nucleotide sequence encoding SEQ ID NO:1; and a 3′ untranslated region operatively linked for functional expression.
3. The vector of claim 2 , wherein said vector is selected from the group consisting of a plasmid, or a viral vector.