Genetic vaccination device and process for forming an injection therefor
View Patent ↗There is disclosed a genetic vaccination device and a process for forming an injection solution therefor, the device comprising a syringe and canula coupled to a membrane adsorber having genetic material adsorbed thereon, and the process comprising eluting the genetic material from the membrane adsorber so as to form an injection solution containing the genetic material.
1. A device for the injection of material comprising a syringe and a canula having at least one membrane adsorber cartridge between and in fluid communication with said syringe and said canula, said at least one membrane adsorber cartridge comprising a housing containing an anion exchange membrane adsorber that has genetic material adsorbed thereon and is capable of reversibly binding nucleic acids.
2. The device of claim 1 wherein said genetic material is coded DNA.
3. The device of claim 2 wherein said genetic material is selected from the group consisting of plasmids, plasmid derivatives and linear DNA.
4. The device of claim 1 wherein said genetic material is selected from the group consisting of RNA, c-DNA and m-RNA.
5. The device of claim 4 including at least one additive adsorbed on said membrane adsorber.
6. The device of claim 4 wherein said genetic material is enhanced with at least one adjuvant.
7. The device of claim 6 wherein said adjuvant is a DNA sequence.
8. The device of claim 7 wherein said DNA sequence is superimposed on antigen-coded plasmids.
9. The device of claim 1 wherein said membrane adsorber has endotoxins adsorbed thereon so as to form an endotoxin filter.
10. The device of claim 1 including a second membrane adsorber in said cartridge having at least one adjuvant bonded thereto.
11. The device of claim 1 or 10 including a sterile filter disposed downstream of said canula.