Methods for enhancing fluid flow through an obstructed vascular site, and systems and kits for use in practicing the same
View Patent ↗Methods of enhancing fluid flow through a vascular site occupied by a vascular occlusion, as well as systems and kits for use in practicing the same, are provided. In practicing the subject methods, the vascular site is flushed simultaneously with a first dissolution fluid (e.g., an organic matter dissolution fluid and/or an inorganic matter dissolution fluid), and a second dissolution fluid attenuating fluid, where flushing is carried out in a manner such that only a surface of the vascular occlusion is contacted with the non-attenuated dissolution fluid. The subject methods, systems and kits for practicing the same find use in the treatment of a variety of different vascular diseases characterized by the presence of vascular occlusions, including both partial and total occlusions.
1. A method of enhancing fluid flow through a vascular site occupied by an organic matter comprising vascular occlusion, said method comprising:
simultaneously flushing said vascular site with:
(i) an organic matter dissolution fluid; and
(ii) an organic matter dissolution fluid attenuating fluid;
for a period of time sufficient for fluid flow to be enhanced through said vascular site;
with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said organic matter comprising vascular occlusion is contacted with non-attenuated organic matter dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated organic matter dissolution fluid;
whereby fluid flow is enhanced through said vascular site.
2. The method according to claim 1 , wherein said organic matter dissolution fluid comprises an active agent selected from the group consisting of enzymes, surfactants, oxidizing and thrombolytic agents.
3. The method according to claim 1 , wherein said organic matter dissolution fluid attenuating agent is an aqueous fluid.
4. The method according to claim 1 , wherein said organic matter dissolution fluid comprises an oxidizing agent.
5. The method according to claim 4 , wherein said organic matter dissolution fluid attenuating agent comprises an aqueous buffer solution.
6. The method according to claim 5 , wherein said wherein said organic matter dissolution fluid comprises surfactant.
7. The method according to claim 1 , wherein said vascular occlusion is a total occlusion.
8. The method according to claim 1 , wherein said vascular occlusion is a partial occlusion.
9. A method of enhancing fluid flow through a vascular site occupied by an inorganic matter comprising vascular occlusion, said method comprising:
simultaneously flushing said vascular site with:
(i) an inorganic matter dissolution fluid; and
(ii) an inorganic matter dissolution fluid attenuating fluid;
for a period of time sufficient for fluid flow to be enhanced through said vascular site;
with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said inorganic matter comprising vascular occlusion is contacted with non-attenuated inorganic matter dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated inorganic matter dissolution fluid;
whereby fluid flow is enhanced through said vascular site.
10. The method according to claim 9 , wherein said inorganic matter is a calcium phosphate mineral.
11. The method according to claim 9 , wherein said inorganic matter dissolution fluid is an acidic solution.
12. The method according to claim 11 , wherein said inorganic matter dissolution fluid attenuating fluid is a buffer solution.
13. The method according to claim 9 , wherein said vascular occlusion is a total occlusion.
14. The method according to claim 9 , wherein said vascular occlusion is a partial occlusion.
15. A method of enhancing fluid flow through a vascular site occupied by vascular occlusion, said method comprising:
simultaneously flushing said vascular site with:
(i) a dissolution fluid that dissolves both organic and inorganic matter; and
(ii) a dissolution fluid attenuating fluid;
for a period of time sufficient for fluid flow to be enhanced through said vascular site;
with the proviso that said simultaneous flushing occurs in a manner such that only a surface of said inorganic matter comprising vascular occlusion is contacted with non-attenuated dissolution fluid and the remainder of said vascular site is not contacted with non-attenuated dissolution fluid;
whereby fluid flow is enhanced through said vascular site.
16. The method according to claim 15 , wherein said dissolution fluid comprises an acid.
17. The method according to claim 15 , wherein said dissolution fluid comprises a surfactant.
18. The method according to claim 15 , wherein said dissolution fluid attenuating fluid is a buffer solution.
19. The method according to claim 15 , wherein said vascular occlusion is a total occlusion.
20. The method according to claim 15 , wherein said vascular occlusion is a partial occlusion.
21. A lesion dissolution fluid comprising:
an acid; and
a surfactant.
22. The fluid according to claim 21 , wherein said fluid further comprises a salt.
23. The fluid according to claim 21 , wherein said acid is an inorganic acid.
24. The fluid according to claim 21 , wherein said inorganic acid is hydrogen chloride.
25. The fluid according to claim 21 , wherein said surfactant is selected from the group consisting of cationic surfactants, anionic surfactants, zwitterionic surfactants and nonionic surfactants.
26. The fluid according to claim 25 , wherein said surfactant is a cationic surfactant.
27. The fluid according to claim 26 , wherein said cationic surfactant is sodium dodecyl sulfate.