Anti-HLA-DA antibodies and the methods of using thereof
View Patent ↗This invention provides anti-HLA-DR antibodies and the methods of use thereof for the treatment of leukemia or lymphomas, or solid tumors such as ovarian cancer or melanoma.
1. An isolated antibody that binds to HLA-DR, wherein said antibody comprises a heavy chain having an amino acid sequence of SEQ ID NO: 3.
2. The antibody according to claim 1 , wherein said antibody comprises a light chain having an amino acid sequence of SEQ ID NO: 6.
3. The antibody according to claim 2 , wherein said antibody is an IgG1 antibody.
4. The antibody according to claim 2 , wherein said antibody comprises a kappa light chain.
5. An isolated antibody that binds to HLA-DR, wherein said antibody comprises a heavy chain having an amino acid sequence of SEQ ID NO: 9.
6. The antibody according to claim 5 , wherein said antibody comprises a light chain having an amino acid sequence of SEQ ID NO: 12.
7. The antibody according to claim 1 , wherein said antibody is an antibody tetramer, Fab fragment, (Fab′) 2 , or Fv.
8. The antibody according to claim 5 , wherein said antibody is an antibody tetramer, Fab fragment, (Fab′) 2 , or Fv.
9. An antibody conjugate comprising the antibody according to claim 1 .
10. An antibody conjugate comprising the antibody according to claim 5 .
11. The antibody conjugate according to claim 9 , wherein said antibody is conjugated with a cytotoxin.
12. A pharmaceutical composition comprising the antibody according to claim 1 and a pharmaceutical carrier.
13. A pharmaceutical composition comprising the antibody according to claim 5 and a pharmaceutical carrier.