Method and apparatus for determining conditions of biological tissues
View Patent ↗The present invention relates to a method of determining characteristics of biological tissues in humans and animals. In particular, it relates to determining the characteristics of tissues such as the lungs and airways by introducing a sound to the tissue, and recording the sound. The invention further includes an apparatus capable of such measurement. In a first aspect of the present invention there is provided a method of determining characteristics of biological tissue in situ, including: introducing a sound to the tissue at first position; detecting the sound at another position spaced from the first position after it has traveled through the tissue; calculating the velocity and attenuation of sound that has traveled through the tissue from the first position to another position; and correlating the velocity and attenuation of the detected sound to characteristics of the biological tissue.
1. A method of determining characteristics of tissue of the respiratory system in situ, said method including:
introducing an audible sound to the tissue at a first position;
detecting the sound at a second position spaced from the first position after it has traveled through the tissue;
calculating the velocity and attenuation of sound that has traveled through the tissue from the first position to the second position; and
correlating the velocity and attenuation of the detected sound to characteristics of the tissue of the respiratory system.
2. A method according to claim 1 wherein the characteristics include any one of make-up of tissue, volume, condition or position in the body.
3. A method according to claim 1 wherein the tissue of the respiratory system is selected from the group including lung tissue or tissues of the upper airway.
4. A method according to claim 1 wherein the audible sound is produced with frequencies in the range of 20 Hz to 25 kHz.
5. A method according to claim 1 wherein the sound is produced at a sound pressure level between 1 and 100 Pascal.
6. A method according to claim 1 wherein the sound is detected by a sound detector means including a microphone or a vibration detector having a frequency response that is flat in the acoustic region.
7. A method according to claim 6 wherein the frequency response that is flat in the acoustic region is between 20 Hz and 25 kHz.
8. A method according to claim 1 wherein a characteristic being determined is a state of the upper airways in a respiratory tract in a patient in situ, and wherein:
the first position is in the upper airways;
the sound is detected at the second position after it has traveled through the upper airways;
the calculated velocity and attenuation is of the sound that has traveled through the upper airways; and
the velocity and attenuation of the sound is correlated to a characteristic being the state of the upper airways.
9. A method according to claim 8 wherein the state of the upper airways is determined as an obstructed or open airway.
10. A method according to claim 8 wherein the state of the upper airways is determined to monitor obstructive sleep apnoea and wherein a change in the velocity and attenuation of the sound indicates a change in the state of the upper airway.
11. A method according to claim 8 wherein the first position in the upper airways is in the nasal region and the second position spaced from the first position is in the upper chest region below the neck and above the lung.
12. A method according to claim 1 wherein the characteristics are determined for monitoring lung condition in situ, and wherein:
the audible sound is introduced transthoracically so that the sound travels from the first position on one side of the thorax, through the lung, to the second position on another side of the thorax;
the calculating step includes measuring the velocity and attenuation of the sound as it travels from one side of the thorax, through and across the lung, to the second position the other side of the thorax; and
the attenuation, the sound velocity and velocity dispersion are correlated to a characteristic being lung condition.
13. A method according to claim 12 wherein the lung condition is selected from the group including:
(a) lung tissue density;
(b) lung gas volume;
(c) regional collapse (atelectasis);
(d) regional blood volume, interstitial oedema; and
(e) focal lung pathology including tumour and global lung disease.
14. A method according to claim 1 wherein the characteristics are determined for measuring lung inflation, and wherein:
the audible sound is introduced transthoracically so that the sound travels from the first position on one side of the thorax, through the lung, to the second position on another side of the thorax;
the calculating step includes measuring the velocity and attenuation of the sound as it travels from one side of the thorax, through and across the lung, to the other side of the thorax; and
changes in sound velocity and attenuation are correlated with characteristics being lung volume and inflation.
15. A method according to claim 1 wherein the characteristics are determined for predicting chronic lung disease in infants and wherein:
the audible sound is introduced transthoracically so that the sound travels from the first position on one side of the thorax, through the lung, to the second position on another side of the thorax;
the calculating step includes measuring the velocity and attenuation of the sound as it travels from one side of the thorax, through and across the lung, to the other side of the thorax; and
the correlating step includes comparing the measured sound velocity and attenuation with that of a normal lung in the absence of chronic lung disease.
16. A method according to claim 1 wherein the characteristics are determined for diagnosing lung disease, said method including measuring lung density and wherein:
the audible sound is introduced transthoracically so that the sound travels from the first position on one side of the thorax, through the lung, to the second position on another side of the thorax;
the calculating step includes measuring the velocity and attenuation of the sound as it travels from one side of the thorax, through and across the lung, to the other side of the thorax; and
the correlating step includes correlating sound velocity and attenuation with a characteristic being lung density and comparing the density of the lung being diagnosed with the density of a normal lung to determine if the lung being diagnosed is diseased.
17. A method according to claim 16 wherein the lung disease is selected from the group including emphysema, asthma, regional collapse (atelectasis), interstitial oedema, focal lung disease and global lung disease.
18. A method according to claim 1 wherein the characteristics are determined for preventing lung injury, said method including monitoring lung condition wherein:
the audible sound is introduced transthoracically so that the sound travels from the first position on one side of the thorax, through the lung, to the second position another side of the thorax;
the calculating step includes measuring the velocity and attenuation of the sound as it travels from one side of the thorax, through and across the lung, to the other side of the thorax;
the correlating step includes correlating the sound velocity and attenuation with a characteristic being lung volume; and the method further includes the step of:
maintaining a lung volume at an optimal volume such that the lung is substantially free of atelectasis or over-inflation (volutrauma).