Dry powders of metal-containing compounds
View Patent ↗Dry powders of metal-containing compounds are disclosed. Methods of preparing and using the dry powders, particularly in the treatment of a subject having a condition, are also disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.
1. A method of treating a human or animal subject having a condition, the method comprising:
contacting an area of the subject having the condition with an antimicrobial nanocrystalline metal-containing compound by dry inhaling a safe and therapeutically effective amount of a free-standing powder of the antimicrobial nanocrystalline metal-containing compound, wherein:
the condition is selected from the group consisting of bacterial respiratory conditions, microbial respiratory conditions, fungal respiratory conditions and viral respiratory conditions,
the antimicrobial nanocrystalline metal-containing compound contains a metal selected from the group consisting of silver, gold, platinum and palladium, and
the free-standing powder of the antimicrobial nanocrystalline metal-containing compound has an average particle size of less than about two microns.
2. The method of claim 1 , wherein the antimicrobial nanocrystalline metal-containing compound is selected from the group consisting of silver, gold, platinum, palladium, and alloys thereof.
3. The method of claim 1 , wherein the antimicrobial nanocrystalline metal-containing compound is an oxide, nitride, boride, halide or hydride of silver, gold, platinum or palladium.
4. The method of claim 1 , wherein the antimicrobial nanocrystalline metal-containing compound comprises silver.
5. The method of claim 1 , antimicrobial nanocrystalline metal-containing compound comprises an ionic compound of silver, gold, platinum or palladium.
6. The method of claim 1 , wherein the antimicrobial nanocrystalline metal-containing compound comprises atoms, molecules or clusters of silver, gold, platinum or palladium.
7. The method of claim 1 , wherein the antimicrobial nanocrystalline metal-containing compound comprises an atomically disordered, crystalline compound of silver, gold, platinum or palladium.
8. The method of claim 1 , wherein the condition is selected from the group consisting of bronchitis, tuberculosis, pneumonia, sinusitis, and pharyngitis.
9. The method of claim 1 , wherein the free-standing powder is inhaled with a dry powder inhaler.
10. The method of claim 1 , wherein the free-standing powder has an average particle size of about one micron or less.
11. The method of claim 1 , wherein the condition is a bacterial respiratory condition.
12. The method of claim 1 , wherein the condition is a microbial respiratory condition.
13. The method of claim 1 , wherein the condition is a fungal respiratory condition.
14. The method of claim 1 , wherein the condition is a viral respiratory condition.
15. The method of claim 1 , wherein the condition is bronchitis.
16. The method of claim 1 , wherein the condition is tuberculosis.
17. The method of claim 1 , wherein the condition is pneumonia.
18. The method of claim 1 , wherein the condition is sinusitis.
19. The method of claim 1 , wherein the condition is pharyngitis.
20. The method of claim 1 , wherein the condition is pneumonia and the antimicrobial nanocrystalline metal-containing compound comprises silver.