Mixing and delivery of therapeutic compositions
View Patent ↗Syringe systems for mixing and delivery of particles into the body are disclosed. In some embodiments, a mixing and delivery medical syringe system can include a barrel including first and second detachable sections, and first and second compartments communicable through a conduit.
1. A mixing and delivery medical syringe system, comprising:
a syringe barrel including an upper compartment and a lower compartment;
wherein the upper compartment and the lower compartment are detachably connectable to each other;
a failure membrane disposed in the upper compartment;
wherein the failure membrane is planar and includes:
a first peripheral region having a first thickness,
a second region connected to the first peripheral region, the second region having a second thickness less than the first thickness,
a third region connected to the second region, the third region having a third thickness that is equal to the first thickness,
a fourth region connected to the third region, the fourth region having a fourth thickness that is less than the first thickness and that is greater than the second thickness, and
a fifth peripheral region connected to the fourth region, the fifth peripheral region having a fifth thickness that is equal to the first thickness;
a vial of embolic material disposed in the upper compartment;
a vial of contrast agent disposed in the lower compartment; and
a plunger having a base.
2. The system of claim 1 , wherein the upper compartment has a female connector on a bottom end thereof.
3. The system of claim 2 , wherein the lower compartment has a male connector on a top end thereof, the male connector being configured to connect with the female connector.
4. The system of claim 1 , wherein the second region of the failure membrane is a failure region.
5. The system of claim 1 , wherein the fourth region of the failure membrane is a hinge region.
6. The system of claim 5 , wherein the failure membrane is circular and has a circumference, and wherein the hinge region extends along a short segment of the circumference of the failure membrane.
7. The system of claim 1 , wherein the failure membrane includes cellulose acetate.
8. The system of claim 1 , wherein the vial of embolic material includes saline.
9. The system of claim 1 , further comprising a stopcock attached to the lower compartment.