Injectable solution of an LHRH antagonist
View Patent ↗An aqueous injectable soution of an LHRH antagonist, such as Cetrorelix, in an organic, pharmaceutically acceptable acid, such as gluconic acid.
1. An aqueous solution of about 500 mg of one LHRH antagonist or a combination of LHRH antagonists selected from the group consisting of cetrorelix, teverelix, D-63153 (Ac-D-Nal-D-pCl-Phe-D-Pal-Ser-N-Me-Tyr-D-Hci-Nle-Arg-Pro-D-Ala-NH2), ganirelix, abarelix, antide, and azaline; about 2.4 g of an acid selected from the group consisting of carboxylic acid, hydroxycarboxylic acid, gluconic acid, and gluconic acid deltalactone; about 2.0 g Tween 80; about 95 g mannitol; in water; to form a solution with a volume of about 10 mL to 2 Liters.
2. An aqueous solution of about 500 mg D-63153; about 100 mg Tween 80; about 475 mg mannitol; in water; to form a solution with a volume of about 10 mL to 2 Liters.
3. An aqueous solution of about 100 mg teverelix; about 100 mg Tween 80; about 475 mg mannitol; in water; to form a solution with a volume of about 10 mL to 2 Liters.
4. The aqueous injectable solution of claim 1 , wherein the acid is gluconic acid deltalactone.
5. The aqueous injectable solution of claim 1 , wherein the LHRH antagonist is Cetrorelix and the acid is gluconic acid deltalactone.
6. The aqueous injectable solution of claim 1 , wherein the volume of the aqueous injectable solution is about 10 mL.
7. A method for producing an aqueous injectable solution of an LHRH antagonist or a combination of LHRH antagonists, as in any of claims 1 – 3 , 4 – 5 , or 6 , which comprises either (a) compounding an injectable solution of an LHRH antagonist; Tween; and mannitol in a pharmaceutically acceptable organic acid and water; or (b) dissolving an LHRH antagonist; Tween; and mannitol in a pharmaceutically acceptable organic acid; homogenizing the resulting solution; and recovering it in an injectable form.
8. The method of claim 7 , wherein said acid is a carboxylic acid.
9. The method of claim 8 , wherein said acid is hydroxycarboxylie acid.
10. The method of claim 9 , wherein said acid is gluconic acid deltalactone.