IP Library › Granted Patent US 6,878,105

Granted Patent B2

US 6,878,105 · App. 10/279,772 · Granted Apr 12, 2005

Red blood cell processing systems and methods with deliberate under spill of red blood cells

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Quick Facts

Patent No.: US 6,878,105
App. No.: 10/279,772
Granted: Apr 12, 2005
Kind: B2

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Abstract

Collection systems and methods use a separation chamber that receives blood or a suspension containing red blood cells and performs a separation process including separation of red blood cells from the blood or suspension. The separation chamber contains, during the separation process, a red blood cell volume. An outlet line is coupled to the separation chamber to remove red blood cells from the chamber device, at least in part, while the separation process occurs. A collection container is coupled to the outlet line to receive a volume of red blood cells removed from the separation chamber. A controller includes a processing function that, during the separation process, includes comparing the volume of red blood cells received by the collection container to a selected targeted red blood cell collection volume to derive a difference. The controller includes another processing function that includes purging substantially all the red blood cell volume occupying the separation chamber into the collection container when the red blood cell volume occupying the separation chamber approximates the difference.

Claims (92)

1. A collection system comprising

a separation chamber that receives blood or a suspension containing red blood cells and performs a separation process including separation of red blood cells from the blood or the suspension, the separation chamber containing, during the separation process, a red blood cell volume,

an outlet line coupled to the separation chamber to remove red blood cells from the chamber device, at least in part, while the separation process occurs,

a collection container coupled to the outlet line to receive a volume of red blood cells removed from the separation chamber, and

a controller including a processing function that, during the separation process, includes comparing the volume of red blood cells received by the collection container to a selected targeted red blood cell collection volume to derive a difference, and another processing function that includes purging substantially all the red blood cell volume occupying the separation chamber into the collection container when the red blood cell volume occupying the separation chamber approximates the difference.

2. A system according to claim 1

wherein the separation chamber performs the separation process by generating a centrifugal separation field.

3. A system according to claim 1

wherein the separation chamber comprises a body preformed to hold a fixed blood volume.

4. A system according to claim 3

wherein the body of the separation chamber is preformed by molding.

5. A system according to claim 1

wherein the other processing function includes conveying a volume of blood into the separation chamber to displace the red blood cell volume from the separation chamber.

6. A system according to claim 5

wherein the other processing function includes determining, as a function of blood hematocrit, red blood cell hematocrit, and configuration of the separation chamber, the volume of blood that is to be conveyed into the separation chamber to displace the red blood cell volume.

7. A system according to claim 1

wherein the separation process includes separation of blood into a plasma volume, the red blood cell volume, and a leukocyte volume, and

wherein the other processing function includes purging substantially all the plasma volume and the leukocyte volume from the separation chamber prior to purging substantially all the red blood cell volume from the separation chamber.

8. A system according to claim 7

wherein the other processing function includes preventing substantially all the plasma volume and the leukocyte volume purged from the separation chamber from entering the collecting container.

9. A system according to claim 1

wherein the other processing function includes conveying a volume of blood into the separation chamber and performing the separation process while purging the red blood cell volume from the separation chamber.

10. A system according to claim 9

11. A blood separation system comprising

a separation chamber having a fixed volume that, in use, performs a separation process including separation of blood into a red blood cell volume, a plasma volume, and a leukocyte volume,

a blood inlet line coupled to the separation device to convey blood into the separation device, at least in part, while the separation process occurs,

a plasma outlet line coupled to the separation device to convey plasma from the separation device, at least in part, while the separation process occurs,

a red blood cell outlet line coupled to the separation device to remove red blood cells from the separation device, at least in part, while the separation process occurs,

a collection container coupled to the red blood cell outlet line to receive red blood cells removed from the separation chamber, and

a controller including a processing function that, during the separation process, includes comparing a collected volume of red blood cells received by the collection container to a selected targeted red blood cell collection volume to derive a difference, and another processing function that includes purging substantially all the red blood cell volume occupying the separation chamber into the collection container when the red blood cell volume occupying the separation chamber approximates the difference.

12. A system according to claim 11

wherein the separation chamber performs the separation process by generating a centrifugal separation field.

13. A system according to claim 11

wherein the separation chamber comprises a body preformed to hold a fixed blood volume.

14. A system according to claim 13

wherein the body of the separation chamber is preformed by molding.

15. A system according to claim 11

wherein the other processing function includes conveying a volume of blood into the separation chamber to displace the red blood cell volume from the separation chamber.

16. A system according to claim 15

17. A system according to claim 11

wherein the other processing function includes purging substantially all the plasma volume and all the leukocyte volume from the separation chamber prior to purging substantially all the red blood cell volume from the separation chamber.

18. A system according to claim 17

wherein the other processing function includes preventing substantially all the plasma volume and all the leukocyte volume purged from the separation chamber from entering the collecting container.

19. A system according to claim 11

20. A system according to claim 19

21. A collection method comprising the steps of

conveying blood or a suspension containing red blood cells into a separation chamber to perform a separation process including separation of red blood cells from the blood or the suspension, the separation chamber containing, during the separation process, a volume of red blood cells,

removing red blood cells from the chamber device, at least in part, while the separation process occurs,

collecting in a collection container a volume of red blood cells removed from the separation chamber, and

performing a processing function that, during the separation process, includes comparing the volume of red blood cells that are collected to a selected targeted red blood cell collection volume to derive a difference, and

performing another processing function that includes purging substantially all red blood cells occupying the separation chamber into the collection container when the volume of red blood cells occupying the separation chamber approximates the difference.

22. A method according to claim 21

wherein the separation process includes generating a centrifugal separation field.

23. A method according to claim 21

wherein the other processing function includes conveying a volume of blood into the separation chamber to displace the volume of red blood cells from the separation chamber.

24. A method according to claim 23

25. A method according to claim 21

wherein the separation process includes separation of blood into a plasma volume, the volume of red blood cells, and a leukocyte volume, and

26. A method according to claim 25

wherein the other processing function includes preventing substantially all the plasma volume and the leukocyte volume purged from the separation chamber from entering the collecting container.

27. A method according to claim 21

wherein the other processing function includes conveying a volume of blood into the separation chamber and performing the separation process while purging the volume of red blood cells from the separation chamber.

28. A method according to claim 27

29. A blood separation method comprising the steps of

conveying blood into a separation chamber having a fixed volume to perform a separation process including separation of blood into a red blood cell volume, a plasma volume, and a leukocyte volume,

conveying blood into the separation device, at least in part, while the separation process occurs,

conveying plasma from the separation device, at least in part, while the separation process occurs,

removing red blood cells from the separation device, at least in part, while the separation process occurs,

collecting in a collection container a volume of red blood cells removed from the separation chamber,

performing a processing function that, during the separation process, includes comparing the volume of red blood cells collected in the collection container to a selected targeted red blood cell collection volume to derive a difference, and

performing another processing function that includes purging substantially all the red blood cell volume occupying the separation chamber into the collection container when the red blood cell volume occupying the separation chamber approximates the difference.

30. A method according to claim 29

wherein the separation process generates a centrifugal separation field.

31. A method according to claim 29

wherein the other processing function includes conveying a volume of blood into the separation chamber to displace the red blood cell volume from the separation chamber.

32. A method according to claim 31

33. A method according to claim 29

34. A method according to claim 33

wherein the other processing function includes preventing substantially all the plasma volume and all the leukocyte volume purged from the separation chamber from entering the collecting container.

35. A method according to claim 29

36. A method according to claim 35

Assignments (6)

RELEASE OF SECURITY INTEREST Recorded Dec 17, 2012

From: MORGAN STANLEY & CO. LLC

To: FENWAL, INC.; FENWAL HOLDINGS, INC.

Reel/Frame 029480/0549 →

RELEASE OF SECURITY INTEREST Recorded Dec 17, 2012

From: MORGAN STANLEY & CO. LLC

To: FENWAL, INC.; FENWAL HOLDINGS, INC.

Reel/Frame 029480/0597 →

SECOND-LIEN INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded May 15, 2007