IP Library › Granted Patent US 6,897,208

Granted Patent B2

US 6,897,208 · App. 10/279,834 · Granted May 24, 2005

Benzimidazoles

View Patent ↗

Loading inventors, assignments & file history…

Monitor This Case

Get email alerts when status or documents change.

Order Certified Copies

Most orders are placed with the USPTO same day — all within 24 business hours.

Order via The Patent Place →

Pre-filled with this patent's details

Quick Facts

Patent No.: US 6,897,208
App. No.: 10/279,834
Granted: May 24, 2005
Kind: B2

External Links

USPTO Patent Center↗ Full Patent PDF↗

Abstract

The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (Ix), and to processes for their preparation. Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.

Claims (942)

1. A compound of general formula (Ix)

wherein

X, Y, Z, and W are carbon atoms;

A 5 represents H or alkyl;

R 1 is a pyrazolyl moiety in which

R 7 is hydrogen or alkyl,

R 8 is selected from the group consisting of hydrogen, carboxy, cyano, halo, haloalkyl, hydroxy, nitro, R 14 , —C(═O)R 4 , —C(═O)NY 1 Y 2 , —C(═O)OR 4 , —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —N(R 6 )C(═O)OR 4 , —N(R 6 )SO 2 R 4 , —N(R 6 )SO 2 NY 1 Y 2 , —NY 1 Y 2 , —OR 4 , —OC(═O)R 4 , —OC(═O)NY 1 Y 2 , —S(O) n R 4 and —S(O) 2 NY 1 Y 2 , and R 9 is selected from the group consisting of hydrogen, carboxy, cyano, halo, haloalkyl, hydroxy, nitro, R 4 , —C(═O)R 4 , —C(═O)NY 1 Y 2 , —C(═O)OR 4 , —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —N(R 6 )C(═O)OR 4 , —N(R 6 )SO 2 R 4 , —N(R 6 )SO 2 NY 1 Y 2 , —NY 1 Y 2 , —OR 4 , —OC(═O)R 4 , —OC(═O)NY 1 Y 2 , —S(O) n R 4 and —S(O) 2 NY 1 Y 2 ; or R 8 and R 9 together with the carbon atoms to which they are attached form (i) a 5 to 8 membered carbocyclic ring optionally substituted by one or more carbocyclic ring substituents; (ii) a phenyl ring optionally substituted by one or more aryl group substituents; (iii) a 5 or 6 membered heteroaromatic ring in which one or more of the ring members is/are nitrogen, oxygen or sulfur and which is optionally substituted by one or more group selected from haloalkyl, hydroxy, halo, cyano, nitro, R 4 , —C(═O)NY 1 Y 2 , —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —N(R 6 )SO 2 R 4 , —NY 1 Y 2 and —OR 5 ; or (iv) a 5 or 6 membered heterocyclic ring unsubstituted or substituted by alkyl or oxo, and comprising a heteroatom-containing group selected from O, S, SO 2 , and NY 5 , where Y 5 is hydrogen, R 4 , —C(═O)R 4 , —C(═O)NY 1 Y 2 , —C(═O)OR 4 or —SO 2 R 4 ;

R 2 and R 3 are attached to X, Y, Z, or W but they are not attached to the same atom simultaneously;

R 2 and R 3 are independently H, carboxy, cyano, halo, haloalkyl, hydroxy, nitro, R 24 , —C(═O)R 4 , —C(═O)NY 1 Y 2 , —C(═O)OR 4 , —NY 1 Y 2 , —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —N(R 6 )C(═O)OR 4 , —N(R 6 )SO 2 R 4 , —N(R 6 )SO 2 NY 1 Y 2 , —OR 4 , —OCF 2 H, —OCF 3 , —OC(═O)R 4 , —OC(═O)NY 1 Y 2 , —S(O) n R 4 , —S(O) n NY 1 Y 2 or —S(O) n OR 4 , provided that R 2 and R 3 are not both H simultaneously; or

R 2 represents , carboxy, cyano, halo, haloalkyl, hydroxy, nitro, R 4 , —C(═O)R 4 , —C(═O)NY 1 Y 2 , —C(═O)OR 4 , —NY 1 Y 2 , —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —N(R 6 )C(═O)OR 4 , —N(R 6 )SO 2 R 4 , —N(R 6 )SO 2 NY 1 Y 2 , —OR 4 , —OCF 2 H, —OCF 3 , —OC(═O)R 4 , —OC(═O)NY 1 Y 2 , —S(O) n R 4 , —S(O) n NY 1 Y 2 or —S(O) n OR 4 and R 3 represents alkyl, haloalkyl, halogen and OR 6 ;

R 4 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, each optionally substituted with one or more substituents selected from alkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, halo, hydroxy, hydroxyalkyl —C(═O)NY 3 Y 4 , —C(═O)OR 6 , —N( 6 )C(═O)NY 1 Y 2 , —NY 1 Y 2 , —OR 5 or alkyl substituted by —NY 3 Y 4 ;

R 14 is alkyl with more than one carbon atoms, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, each optionally substituted with one or more substituents selected from alkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, halo, hydroxy, hydroxyalkyl, —C(═O)NY 3 Y 4 , —C(═O)OR 6 , —N(R 6 )C(═O)NY 1 Y 2 , —NY 1 Y 2 , —OR 5 or alkyl, substituted by —NY 3 Y 4 ;

R 24 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heteroaryl, each optionally substituted with one or more substituents selected from alkyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, halo, hydroxy, hydroxyalkyl, —C(═O)NY 3 Y 4 , —C(═O)OR 6 , —N(R 6 )C(═O)NY 1 Y 2 , —NY 1 Y 2 , —OR 5 or alkyl substituted by —NY 3 Y 4 ;

R 5 is alkyl, alkenyl, aryl, arylalkyl, cycloalkyl, cycloalkylalky, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl;

R 6 is alkyl, alkenyl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkylalkyl;

n is zero or an integer 1 or 2;

Y 1 and Y 2 are independently hydrogen, alkenyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, heterocycloalkyalkyl or alkyl optionally substituted by one or more groups selected from cyano, aryl, heteroaryl, hydroxy, —C(═O)OR 6 , —C(═O)NY 3 Y 4 , —NY 3 Y 4 and OR 5 , or the group —NY 1 Y 2 may from a cyclic amine;

Y 3 and Y 4 are independently hydrogen, alkenyl, alkyl, aryl, arylalkyl, cycloalkyl heteroaryl or heteroarylalkyl; or the group —NY 3 Y 4 may form a cyclic amine;

where

all the alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl radicals present in the above radicals are optionally substituted with one or more radicals chosen from halogen atoms and hydroxyl, cyano, alkyl, alkoxy, acylamino (NH—COalk), —C(═O)OR 6 , —C(═O)R 6 , hydroxyalkyl, carboxyalkyl, S(O) n -alkyl, S(O) n —NH 2 , S(O) n —NH(alk), S(O) n —N(alk) 2 , CF 3 , OCF 3 , NO 2 , arylalkoxy, aryl, heteroaryl, aryloxy, aryloxyalkyl, —C(═O)—NY 3 Y 4 and NY 3 Y 4 radicals, the latter radicals containing alkyl, aryl and heteroaryl being themselves optionally substituted with one or more radicals chosen from halogen atoms and alkyl radicals, free, salified or esterified carboxyl radicals and acylamino radicals NH—C(O)R 5 ;

or an N-oxide, prodrug, acid bioisostere, pharmaceutically acceptable salt or solvate of said compound, or an N-oxide, prodrug, or acid bioisostere of said salt or solvate.

2. A pharmaceutical composition comprising a compound of claim 1 in a pharmaceutically acceptable carrier or excipient.

3. A compound according to claim 1 of formula (Ixa)

wherein

R 7 is hydrogen or alkyl,

R 8 and R 9 are independently selected from hydrogen, carboxy, cyano, halo, haloalkyl, hydroxy, nitro, R 14 , —C(═O)R 4 , —C(═O)NY 1 Y 2 , C(═O)OR 4 , —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —N(R 6 )C(═O)OR 4 , —N(R 6 )SO 2 R 4 , —NY 1 Y 2 , —OR 4 , —OC(═O)R 4 , —OC(═O)NY 1 Y 2 , —S(O) n R 4 and

—S(O) 2 NY 1 Y 2 , where X,Y,Z, W, R 4 , R 6 , Y 1 , Y 2 , and n are defined in claim 1 ; or an N-oxide, prodrug, acid bioisostere pharmaceutically acceptable salt or solvate of such compound; or an N-oxide, prodrug, or acid bioisostere of such salt or solvate.

4. A compound according to claim 3 wherein R 2 and R 3 are independently alkyl, aryl, CN, NO2, halo, halo-alkyl, heteroaryl, OR4, C(═O)R 4 , C(═O)NY 1 Y 2 , C(═O)OR 4 , NHC(═O)R 4 CH(OH) aryl, S(O) 2 NY 1 Y 2 , or S(O) n R 4 , where R 4 , R 6 , Y 1 , Y 2 , and n are defined in claim 1 .

5. A compound according to claim 3 wherein

R 2 is attached to X and R 3 is attached to Y;

R2 is CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 , OCH 3 , OCH 2 CH 3 , Br, Or Cl;

R3 is CH 3 , CH 2 CH 3 , OCH 3 , Br, Cl, F,

6. A compound according to claim 3 wherein R 2 is CH 3 and is attached to Y and R 3 is CH 3 and is attached to Z.

7. A compound according to claim 3 wherein CR 2 is attached to X; CR 3 is attached to Y, and R 2 and R 3 form the group —CH 2 —O—CH 2 .

8. A compound according to claim 3 wherein CR 2 is attached to X; CR 3 is attached to Y, and R 2 and R 3 form the group —CH 2 —CH 2 —CH 2 .

9. A compound according to claim 3 wherein R 7 represents hydrogen.

10. A compound according to claim 3 wherein R 8 represents hydrogen, C 1-4 alkyl, —SR 4 , —NY 1 Y 2 or —OR 5 .

11. A compound according to claim 3 wherein R 9 represents hydrogen, C 1-7 alkyl, aryl, —C(═O)NY 1 Y 2 , —N(R 6 )C(═O)R 4 , where R 4 is alkyl optionally substituted by aryl, cycloalkyl, heteroaryl, heterocycloalkyl, or where R 4 is NY 1 Y 2 or —OR 5 or where R 4 is aryl, or where R 4 is cycloalkyl, or where R 4 is heteroaryl, or when R 4 is heterocycloalkyl; or R 9 represents —N(R 6 )C(═O)NY 1 Y 2 , —NY 1 Y 2 , or alkyl substituted by —N(R 6 )C(═O)NY 1 Y 2 .

12. A compound according to claim 3 wherein

R 2 is H;

R 3 is H; or R 3 is CH 3 and is attached to Z;

R 7 represents hydrogen;

R 8 represents hydrogen, C 2-4 alkyl, —SR 4 , —NY 1 Y 2 ; and

R 9 represents hydrogen, C 2-7 alkyl, aryl, —C(═O)NY 1 Y 2 , —N(R 6 )C(═O)R 4 , particularly —NHC(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —NY 1 Y 2 , or alkyl substituted by —N(R 6 )C(═O)NY 1 Y 2 .

13. A compound according to claim 3 wherein

R2is H;

R3 is attached to Y and Y-R3 represents

C—C 1-4 alkyl, C-aryl, C—CN, C—NO 2 , C-halo, C-haloalkyl, C-heteroaryl, C—OR 4 , C—C(═O)R 4 , C—C═O)NY 1 Y 2 , C—C(═O)OR 4 , or C—CH(OH)aryl;

R 8 represents hydrogen, C 2-4 alkyl, —SR 4 , —NY 1 Y 2 or —OR 5 ; and

R 9 represents hydrogen, C 2-7 alkyl, aryl, —C(═O)NY 1 Y 2 , —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , NY 1 Y 2 , or alkyl substituted by —N(R 6 )C(═O)NY 1 Y 2 .

14. A compound according to claim 3 wherein

R 2 is attached to X and X—R 2 represents C—CH 3 , C—CH 2 CH 3 , C—CH(CH 3 ) 2 , C—OCH 3 , C—OCH 2 CH 3 , C—Br or C—Cl;

R 3 is attached to Y and Y—R 3 represents C—CH 3 , C—CH 2 CH 3 , C—OCH 3 , C—Br, C—Cl, C—F,

R 7 represents hydrogen;

R 8 represents hydrogen, C 2-4 alkyl, —SR 4 , —NY 1 Y 2 , or —OR 5 ; and

R 9 represents hydrogen, C 2-7 alkyl, aryl, —C(═O)NY 1 Y 2 , —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —NY 1 Y 2 , or alkyl substituted by —N(R 6 )C(═O)NY 1 Y 2 .

15. A compound according to claim 3 wherein

R 2 and R 3 are CH 3 and attached to Y and Z, respectively;

R 7 represents hydrogen;

R 8 represents hydrogen, C 2-4 alkyl, —SR 4 , —NY 1 Y 2 , or —OR 5 ; and

R 9 represents hydrogen, C 2-7 alkyl, aryl, —C(═O)NY 1 Y 2 ; —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —NY 1 Y 2 , or alkyl substituted by —N(R 6 )C(═O)NY 1 Y 2 .

16. A compound according to claim 3 wherein

CR 2 is attached X and CR 3 is attached to Y, where R 2 and R 3 form the group —CH 2 —O—CH 2 —;

R 7 represents hydrogen;

R 8 represents hydrogen, C 2-4 alkyl, —SR 4 , —NY 1 Y 2 , or —O 5 ; and

R 9 represents hydrogen, C 2-7 alkyl, aryl, —C(═O)NY 1 Y 2 ; —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —NY 1 Y 2 , or alkyl substituted by —N(R 6 )C(═O)NY 1 Y 2 .

17. A compound according to claim 3 wherein

CR 2 is attached to X and CR 3 is attached to Y, where R 2 and R 3 form the group —CH 2 —CH 2 —CH 2 —;

R 7 represents hydrogen;

R 8 represents hydrogen, C 2-4 alkyl, —SR 4 , —NY 1 Y 2 , or —OR 5 ; and

R 9 represents hydrogen, C 2-7 alkyl, aryl, —C(═O)NY 1 Y 2 , —N(R 6 )C(═O)R 4 , —N(R 6 )C(═O)NY 1 Y 2 , —NY 1 Y 2 or alkyl substituted by —N(R 6 )C(═O)NY 1 Y 2 .

18. A compound according to claim 3 wherein

R 8 is hydrogen or —CH 3 ; and

R 9 is —CH 2 —CH(CH 3 ) 2 ,

19. A compound according to claim 3 wherein R 9 represents hydrogen and R 8 represents

—CH(CH 3 ) 2 , —S—CH 3 , —S—CH 2 CH 3 or

20. A compound according to claim 3 wherein

R 2 is attached to Y; and Y—R 2 is CH, C—CH 2 CH 3 , C—CH 2 CH 2 CH 3 ,

C—CN, C—Br, C—CF 3 ,

C—OCH 3 , C—OCH 3 CH 2 , C—OCHF 2 , C—OCF 3 ,

C—C(═O)—NH—CH 3 , C—C(═O)—NH—CH 2 CH 3 , C—C(═O)—NH—CH(CH 3 ) 2 , C—C(═O)—NH—C(CH 3 ) 2 —CH 2 OH, C—C(═O)—NH—CH 2 CH 2 CN, C—C(═O)—NH—CH 2 CH 2 OCH 3 ,

and Z is CH.

21. A compound according to claim 3 wherein R 2 is attached to X and X—R 2 is C—CH 3 or C—CH 2 CH 3 ; R 3 is attached to Y and Y—R 3 is C—CH 3 , C—CH 2 CH 3 , C—CH(CH 3 ) 2 , C—Br, C—Cl, C—F,

22. A compound according to claim 3 wherein R 2 is attached to X and X—R 2 is C—OCH 3 ; and R 3 is attached to Y and Y—R 3 is CH, C—CH 3 , C—CH 2 CH 3 , C—Cl or C—OCH 3 .

23. A compound according to claim 3 wherein R 2 is attached to X and X—R 2 is C—OCH 2 CH 3 ; and R 3 is attached to Y and Y—R 3 is C—F.

24. A compound according to claim 3 wherein R 2 is attached to X and R 3 is attached to Y, where R 2 and R 3 atoms form the group —CH 2 —CH 2 —CH 2 .

25. A compound according to claim 3 wherein R 2 is attached to X and R 3 is attached to Y, where R 2 and R 3 form the group —CH 2 —O—CH 2 .

26. A compound according to claim 3 wherein R 8 is hydrogen; and

R 9 is —C(═O)—NH—CH 2 CH 3 ,

27. A compound according to claim 3 wherein R 2 is H and is attached to X; and R 3 is attached to Y and Y—R 3 is C-OCH 3 , C—OCH 2 CH 3 , C—OCHF 2 , C—CF 3 ,

and Z is CH.

28. A compound according to claim 3 wherein R 2 is CH 3 or CH 2 CH 3 and is attached to X; and R 3 is attached to Y and Y—R 3 is C—CH 3 or C—CH 2 CH 3 , C—Cl or C—F.

29. A compound according to claim 3 wherein R 2 is attached to X and X—R 2 is C—OCH3; R 3 is attached to Y and Y—R 3 is C—CH3, C—CH2CH3, C—Cl, C—F, or C—OCH3.

30. A compound according to claim 3 wherein R 2 is attached to X and X—R 2 is C—OCH 2 CH 3 ; R 3 is attached to Y and Y—R 3 is C—Cl or C—F.

31. A compound according to claim 3 wherein R 2 is attached to X and R 3 is attached to Y, where R 2 and R 3 form the group —CH 2 —CH 2 —CH 2 .

32. A compound according to claim 3 wherein R 2 is attached to X and R 3 is attached to Y where R 2 and R 3 form the group —CH 2 —O—CH 2 .

33. A compound according to claim 1 selected from the group consisting of:

2-(1H-indazol-3-yl)-1H-benzimidazole-5-carboxylic acid benzylamide;

2-(1H-indazol-3-yl)-1H-benzimidazole-5-carboxylic acid N-methylamide;

2-(1H-indazol-3-yl)-1H-benzimidazole-5-carboxylic acid N-ethylamide;

2-(1H-indazol-3-yl)-1H-benzimidazoIe-5-carboxylic acid N-isopropylamide;

2-(1H-indazol-3-yl)-1H-benzimidazole-5-carboxylic acid N-phenylamide;

2-(1H-indazol-3-yl)-1H-benzimidazole-5-carboxylic acid N-phenethylyamide;

5,6-dimethyl-2-(5-methylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

6-chloro-5-methyl-2-(5-methylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

6-chloro-2(5-ethylsulfanyl-1H-pyrazol-3-yl)-5-methyl-1H-benzoimidazole;

2-(5-methylsulfanyl-1H-pyrazol-3-yl)-5-trifluoromethyl-1H-benzoimidazole;

2-(5-cyclopropylmethylsulfanyl-1H-pyrazol-3-yl)-5,6-dimethyl-1H-benzoimidazole;

2-(5-ethylsulfanyl-1H-pyrazol-3-yl)-5,6-dimethyl-1H-benzoimidazole;

5,6-dimethyl-2-[5-(pyridin-3-ylmethylsulfanyl)-1H-pyrazol-3-yl]-1H-benzoimidazole;

5-fluoro-2-[5-methylsulfanyl)-1H-pyrazol-3-yl]-1H-benzoimidazole;

5,6-dimethyl-2-(5phenethylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

4-methyl-2-(5-methylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

5,6-dimethyl-2(5-bezylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

6-chloro-5-methyl-2-(5-morpholin-4-yl-1H-pyrazol-3-yl)-1H-benzoimidazole;

5,6-dimethyl-2-[5-(thiophen-2-ylmethylsulfanyl)-1H-pyrazol-3-yl]-1H-benzoimidazole;

2-(5-ethylsulfanyl-1H-pyrazol-3-yl)-5-methozy-1H-benzoimidazole hydrochloride;

5-methyl-2-(5-methylsulfanyl-4-propyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

2-(5-(4-methoxy-benzylsulfanyl)-4-propyl-1H-pyrazol-3-yl)-5-methyl-1H-benzoimidazole;

2-(5-benzylsulfanyl-4-isopropyl-1H-pyrazol-3-yl)-5-methyl-1H-benzoimidazole;

2-(5-methylsulfanyl-4-methyl-1H-pyrazol-3-yl)-5-methoxy-1H-benzoimidazole;

2-(5-methylsulfanyl-4-methyl-1H-pyrazol-3-yl)-5-methyl-1H-benzoimidazole;

3-(5-chloro-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

3-(5,6-dichloro-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

3-(5-ethyl-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

3-(6-chloro-5-methoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

3-(5-methoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

3-(5-ethoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

3-(5-fluoro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

3-(5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

3-(5-trifluoromethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

2-(4-amino-1H-pyrazol-3-yl)-1H-benzoimidazole-5-carboxylic acid methyl ester,

3-(1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-methoxy-1H-benzimidazol-2-yl)-1H-indazole;

[2-(indazol-3-yl)-1H-benzoimidazol-5-yl]-phenyl-methanone;

2-(1H-indazol-3-yl)-3H-benzoimidazol-4-ol;

2-phenyl-1H-imidazol[4,5-b]pyrazine;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-indazole;

2-(1H-indazol-3-yl)-3H-imidazo[4,5-c]pyridine;

2-(1H-indazole-3-yl)-3H-imidazo[4,5-b]pyridine;

2-(1H-pyrazol-3-yl)-1H-benzoimidazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-5-methoxy-1H-indazole;

3-(5-ethyl-6-methyl-1H-benzoimidazol-2-yl)-5-methoxy-1H-indazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-5-fluoro-1H-indazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-6-fluoro-1H-indazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-5-methyl-1H-indazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-6-methoxy-1H-indazole;

5,6-dimethyl-2-(4-phenyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

3-(5-ethyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-ethyl-6-methyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-isopropyl-6-methyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-bromo-6-methyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-bromo-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-(3-cyano)phenyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-(pyrid-3-yl)-1H-benzoimidazol-2-yl)-1H-indazole;

3-(6-methyl-5-phenyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-phenyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-(2-fluoro)phenyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-(5,6-methylenedioxy)phenyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-(2-methoxy)phenyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-(4-chloro)phenyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-(4-methyl)phenyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5-benzyloxy-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5,6-methylenedioxy-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5,6-dimethoxy-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5,6-diethyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(4,5-dimethyl-1H-benzoimidazol-2-yl)-1H-indazole;

2-(1H-indazol-3-yl)-1H-benzoimidazole-5-carbonitrile;

3-(5-methoxycarbonyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-5-ethoxy-1H-indazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-pyrazole-4-carboxylic acid ethyl ester;

2-(4-isopropylcarbamoyl-1H-pyrazol-3-yl)-1H-benzoimidazole-5-carboxylic acid methyl ester;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-5-methyl-pyrazole-4-carboxylic acid ethyl ester;

3-(1,5,6,7-tetrahydro-1,3-diaza-s-indacen-2-yl)-1H-pyrazol-2-carboxylic acid cyclopropylamide;

3-(5-methoxy-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid isopropylamide;

3-[5-(2-morpholin-4-yl-ethoxy)-1H-benzoimidazol-2-yl]-1H-indazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (2-methoxy-ethyl)-amide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid propylamide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (tetrahydro-pyran-4-yl)-amide;

3-(5-ethyl-6-methyl-1H-benzoimidazol-2-yl)-1H-indazole-5-carbonitrile;

3-(5-difluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid isopropylamide;

3-(5-difluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid cyclopropylamide;

3-(6-ethyl-5-methoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid isopropylamide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-indazole-5-carbonitrile;

2-(5-methyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

2-(5-ethoxy-1H-pyrazol-3-yl)-1H-benzoimidazole;

2(5-methylsulfanyl-isoxazol-3-yl)-1H-benzoimidazole;

5-chloro-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole;

5,6-dichloro-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole;

(benzoimidazol-2-yl)-5-methylthio-3-pyrazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-4,5,6,7-tetrahydro-1H-indazole;

2-(5-isopropyl-1H-pyrazol-3-yl)-5,6-dimethyl-1H-benzoimidazole;

2-(5-ethyl-1H-pyrazol-3-yl)-5,6-dimethyl-1H-benzoimidazole;

5,6-dimethyl-2-(1,4,5,6-tetrahydro-cyclopentapyrazol-3-yl)-1H-benzoimidazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-4-fluoro-1H-indazole;

4-chloro-3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-indazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-5-chloro-1H-indazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-indazol-5-ol;

3-(5-n-propyl-1H-benzoimidazol-2-yl)-1H-indazole;

2-(1H-indazol-3-yl)-1H-benzoimidazole-5-sulfonic acid benzylamide;

3-(5-methanesulfonyl-1H-benzoimidazol-2-yl)-1H-indazole;

[2-(indazol-3-yl)-1H-benzoimidazol-5-yl]-phenyl-methanol;

[2-(indazol-3-yl)-1H-benzoimidazol-5-yl]-carboxylic acid;

[2-(indazol-3-yl)-1H-benzoimidazol-5-yl]-carboxylic acid, methylamide;

[2-(indazol-3-yl)-1H-benzoimidazol-5-yl]-carboxylic acid, dimethylamide;

[2-(indazol-3-yl)-1H-benzoimidazol-5-yl]-carboxylic acid, isopropylamide;

1H-benzoimidazol-5-yl]-carboxylic acid, benzylamide;

[2-(indazol-3-yl)-1H-benzoimidazol-5-yl]-carboxylic acid, benzamide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid isopropylamide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide,

2-(4-isopropylcarbamoyl-1H-pyrazol-3-yl)-1H-benzoimidazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid cyclopropylamide;

2-(4-isopropylcarbamoyl-1H-pyrazol-3-yl)-1H-benzoimidazole-5-carboxylic acid phenylmethyl-amide;

2-(4-isopropylcarbamoyl-1H-pyrazol-3-yl)-1H-benzoimidazole-5-carboxylic acid (pyridin-2-ylmethyl)-amide;

2-(1H-indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide;

2-(1H-indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid 3-methyl-benzylamide;

2-(1H-indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid 4-methyl-benzylamide;

2-(1H-indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid [3-(2-oxo-pyrrolidin-1-yl)-propyl]-amide;

2-(1H-indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid (2-morpholin-4-yl-ethyl)-amide;

2-(1H-indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid (2-methoxy-ethyl)-amide;

2-(1H-indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid (2-cyano-ethyl)-amide;

2-(1H-indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide;

2-(1H-Indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid (3-imidazol-1-yl-propyl)-amide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid isobutyl-amide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid isopropylamide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid cyclopropylmethyl-amide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-5-methyl-1H-pyrazole-4-carboxylic acid tert-butylamide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-indazole-5-carboxylic acid dimethylamide;

2-(4-isobutyrylamino-1H-pyrazol-3-yl)-1H-benzoimidazole-5-carboxylic acid benzylamide;

[2-(indazol-3-yl)-1H-benzoimidazol-5-yl]-carboxylic acid;

3-(5,6-dimethyl-1H-benzoimidazol-5-yl)-pyrazole-4-carboxylic acid;

2-(4-isopropylcarbamoyl-1H-pyrazol-3-yl)-1H-benzimidazole-5-carboxylic acid;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-5-methyl-pyrazole-4-carboxylic acid;

N-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-isobutyramide;

N-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-3-methyl-butylamide;

N-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-2-phenyl-acetamide;

cyclopropanecarboxylic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazolyl-4-yl]-amide;

methoxyacetic acid [3(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

cyclopentanecarboxylic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

trimethylacetic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

tert-butylacetic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

butanoic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

isoxazole-5-carboxylic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

S(+)-2-methylbutanoic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

cyclopropanecarboxylic acid [3-(5-ethyl-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

piperidine-1-carboxylic acid[3-(6-chloro-5-methoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

3-[3-(6-chloro-5-methoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-1,1-dimethylurea;

cyclopropanecarboxylic acid [3-(5-methoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

cyclopropanecarboxylic acid [3-(5-ethoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

cyclopropanecarboxylic acid [3-(5-fluoro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

cyclopropanecarboxylic acid [3-(5-trifluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

cyclopropanecarboxylic acid [3-(5-trifluoromethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

N-[3-(5-trifluoromethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-isobutyramide;

cyclopropanecarboxylic acid [3-(5-chloro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

3,5-dimethyl-isoxazole-4-carboxylic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

N-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-acetamide;

furan-3-carboxylic acid [3-(5-chloro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

N-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-4-methyl-benzamide;

5,6-dimethyl-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole;

5-ethyl-6-methyl-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole;

6-chloro-5-methoxy-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole;

5-fluoro-6-methyl-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole;

2-(4-nitro-1H-pyrazol-3-yl)-5-trifluoromethoxy-1H-benzoimidazole;

2-(4-nitro-1H-pyrazol-3-yl)-5-trifluoromethyl-1H-benzoimidazole;

5-chloro-6-methyl-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole;

2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole-5-carboxylic acid methyl ester;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid isopropylamide;

cyclopropyl-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-methanone,

isopropyl-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-methanone;

1-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-2,2-dimethyl-propan-1-one;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[3-c]pyridine-5-carboxylic acid methyl ester;

3-(5,6-methyl-1H-benzoimidazol-2-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine;

3-(5-chloro-6-methyl-1H-benzoimidazol-2-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine;

3-[5-(2-morpholin-4-yl-ethoxy)-1H-benzoimidazol-2-yl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine;

3-(5-trifluoromethyl-1H-benzoimidazol-2-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester;

5-methoxy-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole;

5-ethoxy-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole;

3-(5-chloro-6-methyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester;

3-([5-(2-morpholin-4-yl-ethoxy)-1H-benzoimidazol-2-yl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrano[4,3-c]pyrazole;

3-(5-trifluoromethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester;

N-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-2-morpholin-4-yl-acetamide;

2-dimethylamino-N-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-acetamide;

N-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-2-(1H-1,2,3,4-tetraazol-1l-yl)-acetamide;

N-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-isonicotinamide;

2-cyclopropyl-N-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-acetamide;

1-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl)-3-methyl-urea;

1-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-3-isopropyl-urea;

1-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-3-phenyl-urea;

1-benzyl-3-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid isopropylamide;

cyclopropanecarboxylic acid[3-(5-ethoxy-6-ethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]amide;

3-(1,5,6,7-tetrahydro-1,3-diaza-s-indacen-2-yl)-1H-pyrazol-4-ylamine;

4-methylpiperazine-1-carboxylic acid [3-(1,5,6,7-tetrahydro-1,3-diaza-s-indacen-2-yl)-1H-pyrazol-4-yl]amide;

1,1-dimethyl-3-[3-(1,5,6,7-tetrahydro-s-indacen-2-yl)-1H-pyrazol-4-yl]urea;

cyclopropanocarboxylic acid [3-(6-ethoxy-5-fluoro-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]amide;

tetrahydropyran-4-carboxylic acid [3-(6-ethoxy-5-fluoro-1H-benzimidazol-2-yl)-1H-pyrazole-4-yl]amide;

morpholine-4-carboxylic acid[3-(6-ethoxy-5-fluoro-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]amide;

piperidine-4-carboxylic acid[3-(6-ethoxy-5-fluoro-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]amide;

3-[6-ethoxy-5-fluoro-1H-benzimidazol-2-yl)-1H-pyrazol-4-yl]-1,1-diethylurea;

5-methoxy-2-(4-nitro-1H-pyrazol-3-yl)-1H-benzoimidazole;

morpholine-4-carboxylic acid[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylmethyl]-amide;

3-[3-(5-difluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-1,1-diethyl-urea;

piperidine-1-carboxylic acid [3-(5-difluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

cyclopropanecarboxylic acid [3-(6-chloro-5-methoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

cyclopropanecarboxylic acid [3-(1,5,6,7-tetrahydro-1,3-diaza-s-indacen-2-yl)-1H-pyrazol-4-yl]amide;

morpholine-4-carboxylic acid[3-(1,5,6,7-tetrahydro-1,3-diaza-s-indacen-2-yl)-1H-pyrazol-4-yl]-amide;

piperidine-1-carboxylic acid [3-(5-methoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

3-[3-(5-methoxy-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-1,1-dimethyl-urea;

piperidine-1-carboxylic acid [3-(5-ethyl-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

3-[3-(5-fluoro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-1,1-dimethyl-urea;

morpholine-4-carboxylic acid [3-(5-trifluoromethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid diethylamide;

[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-pyrrolidin-1-yl-methanone;

[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-piperidin-1-yl-methanone;

[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-yl]-morpholin-4-yl-methanone;

3-(5-chloro-6-methyl-1H-benzoimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid diethylamide;

morpholine-4-carboxylic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

piperidine-1-carboxylic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

3-[5-(2-morpholin-4-yl-ethoxy)-1H-benzoimidazol-2-yl]-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridin-5-carboxylic acid diethylamide;

3-(5-trifluoromethyl-1H-benzimidazol-2-yl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid diethylamide;

2-(1H-indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid [2-(2H-tetrazol-5-yl)-ethyl]-amide;

1-cyclopropyl-3-[3-(5-ethyl-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea;

1-[3-(5-ethyl-6methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-3-methyl-urea;

4-methyl-piperazine-1-carboxylic acid [3-(5-ethyl-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

piperidine-1-carboxylic acid [3-(5-fluoro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

1-[3-(5-fluoro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-3-methyl-urea;

morpholine-4-carboxylic acid [3-(5-fluoro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

4-methyl-piperazine-1-carboxylic acid [3-(5-fluoro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

1-methyl-3-[3-(5-trifluoromethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea;

1-[3-(5-chloro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-3-methyl-urea;

4-methyl-piperazine-1-carboxylic acid [3-(5-chloro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

1-tert-butyl-3-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea;

1-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-3-ethyl-urea;

4-methyl-piperazine-1-carboxylic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide;

1-cyclopropyl-3-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea;

3-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-1,1-diethyl-urea;

1-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-3-isobutyl-urea;

1-cyclopropylmethyl-3-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea;

3-(5-chloro-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

3-(5-ethyl-6-methyl-1H-benzoimidazol-2-yl)-1H-indazole-5-carboxylic acid amide dihydrochloride;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-indazole-5-carboxylic acid;

2-(4-isobutyrylamino-1H-pyrazol-3-yl)-1H-benzoimidazol-5-carboxylic acid;

3-[3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-1,1-dimethyl-urea;

3-(5-nitro-1H-benzoimidazol-2-yl)-1H-indazole;

2-(1H-Indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid (2-piperidin-1-yl-ethyl)-amide;

2-(1H-Indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid (pyridin-2-ylmethyl)-amide;

2-(1H-Indazol-3-yl)-1H-benzoimidazole-5-carboxylic acid [3-(4-methyl-piperazin-1-yl)-propyl]-amide; N-[2-(1H-Indazol-3-yl)-1H-benzoimidazol-5-yl]-isobutyramide;

N-[3-(5,6-Dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-2-piperidin-1-yl-acetamide;

2-(1H-indazol-3-yl)-3H-benzoimidazol-5-amine; and

piperidine-1-carboxylic acid [3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-amide.

34. A compound according to claim 1 selected from the group consisting of;

2-(1H-indazol-3-yl)-1H-benzimidazole-5-carboxylic acid benzylamide;

2-(1H-indazol-3-yl)-1H-benzimidazole-5-carboxylic acid N-methylamide;

2-(1H-indazol-3-yl)-1H-benzimidazole-5-carboxylic acid N-ethylamide;

2-(1H-indazol-3-yl)-1H-benzimidazole-5-carboxylic acid N-isopropylamide;

2-(1H-indazol-3-yl)-1H-benzimidazole-5-carboxylic acid N-phenylamide;

2-(1H-indazol-3-yl)-1H-benzimidazole-5-carboxylic acid N-phenethylamide;

5,6-dimethyl-2-(5-methylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

6-chloro-5-methyl-2-(5-methylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

6-chloro-2-(5-ethylsulfanyl-1H-pyrazol-3-yl)-5-methyl-1H-benzoimidazole;

2-(5-methylsulfanyl-1H-pyrazol-3-yl)-5-trifluoromethyl-1H-benzoimidazole;

2-(5-cycloproylmethylsulfanyl-1H-pyrazol-3-yl)-5,6-dimethyl-1H-benzoimidazole;

2-(5-ethylsulfanyl-1H-pyrazol-3-yl)-5,6-dimethyl-1H-benzoimidazole;

5,6-dimethyl-2-[5-(pyridin-3-ylmethylsulfanyl)-1H-pyrazol-3-yl]-1H-benzoimidazole;

5-fluoro-2-[5-methylsulfanyl)-1H-pyrazol-3-yl]-1H-benzoimidazole;

5,6-dimethyl-2-(5-phenethylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

4-methyl-2-(5-methylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

5,6-dimethyl-2-(5-benzylsulfanyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

5,6-dimethyl-2-[5-(thiophen-2-ylmethylsulfanyl)-1H-pyrazol-3-yl]-1H-benzoimidazole;

2-(5-ethylsulfanyl-1H-pyrazol-3-yl)-5-methoxy-1H-benzoimidazole hydrochloride;

5-methyl-2-(5-methylsulfanyl-4-propyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

2-(5-(4-methoxy-benzylsulfanyl)-4-propyl-1H-pyrazol-3-yl)-5-methyl-1H-benzoimidazole;

2-(5-benzylsulfanyl-4-isopropyl-1H-pyrazol-3-yl)-5-methyl-1H-benzoimidazole;

2-(5-methylsulfanyl-4-methyl-1H-pyrazol-3-yl)-5-methoxy-1H-benzoimidazole;

2-(5-methylsulfanyl-4-methyl-1H-pyrazol-3-yl)-5-methyl-1H-benzoimidazole;

3-(5-chloro-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

3-(5,6-dichloro-1H-benzoimidazol-2-yl)-1H-pyrazol-4-ylamine;

5,6-dimethyl-2-(4-phenyl-1H-pyrazol-3-yl)-1H-benzoimidazole;

3-(1,5,6,7-tetrahydro-1,3-diaza-s-indacen-2-yl)-1H-pyrazol-4-carboxylic acid cyclopropylamide;

3-(5-methoxy-6-methyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid isopropylamide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (2-methoxy-ethyl)-amide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid propylamide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (tetrahydro-pyran-4-yl)-amide;

3-(5-difluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid isopropylamide;

3-(5-difluoromethoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid cyclopropylamide;

3-(6-ethyl-5-methoxy-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid isopropylamide;

2-(5-ethoxy-1H-pyrazol-3-yl)-1H-benzoimidazole;

(benzoimidazol-2-yl)-5-methylthio-3-pyrazole;

2-(5-isopropyl-1H-pyrazol-3-yl)-5,6-dimethyl-1H-benzoimidazole;

2-(5-ethyl-1H-pyrazol-3-yl)-5,6-dimethyl-1H-benzoimidazole;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid isopropylamide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (2-hydroxy-1,1-dimethyl-ethyl)-amide;

2-(4-isopropylcarbamoyl-1H-pyrazol-3-yl)-1H-benzoimidazole-5-carboxylic acid (pyridin-3-ylmethyl)-amide;

3-(5,6-dimethyl-1H-benzoimidazol-2-yl)-5-methyl-1H-pyrazol-4-carboxylic acid cyclopropylamide;