High viscosity embolizing compositions
View Patent ↗Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.
1. A composition capable of embolizing an aneurysm at a vascular site comprising:
(a) a biocompatible polymer;
(b) a biocompatible contrast agent wherein a sufficient amount of said contrast agent is employed in said composition to effect visualization in vivo; and
(c) a biocompatible solvent which solubilizes said biocompatible polymer
wherein a sufficient amount of said polymer are employed in said composition such that, upon delivery to a vascular site, a polymer precipitate forms which embolizes said vascular site; and
further wherein the biocompatible polymer has a molecular weight sufficient to impart to the composition a viscosity of at least about 150 cSt at 40° C.
2. A composition capable of embolizing an aneurysm at a vascular site comprising:
(a) a biocompatible polymer at a concentration of from about 2 to 50 weight percent;
(b) a biocompatible contrast agent at a concentration of from about 10 to about 40 weight percent; and
(c) a biocompatible solvent from about 10 to 88 weight percent
wherein the weight percents of the biocompatible polymer, contrast agent and biocompatible solvent are based on the total weight of the composition; and
further wherein the biocompatible polymer has a molecular weight sufficient to impart to the composition a viscosity of at least about 150 cSt at 40° C.
3. The composition according to claim 1 or claim 2 , wherein said composition has a viscosity of at least about 200 cSt at 40° C.
4. The composition according to claim 3 , wherein said composition has a viscosity of at least about 500 cSt at 40° C.
5. The composition according to claim 4 , wherein said composition has a viscosity of from about 500 to 5,000 cSt at 40° C.
6. The composition according to claim 1 or claim 2 wherein said composition has a migration distance of less than 25 mm.
7. The composition according to claim 1 or claim 2 , wherein the concentration of biocompatible polymer employed in said composition is from 6 to 50 weight percent.
8. The composition according to claim 7 , wherein the concentration of biocompatible polymer employed in said composition is from 8 to 30 weight percent.
9. The composition according to claim 1 or claim 2 wherein said biocompatible solvent is selected from the group consisting of ethyl lactate, dimethylsulfoxide, ethanol and acetone.
10. The composition according to claim 9 wherein said biocompatible solvent is dimethylsulfoxide.
11. The composition according to claim 1 or claim 2 wherein said contrast agent is a water insoluble contrast agent.
12. The composition according to claim 11 wherein said water insoluble contrast agent is selected from the group consisting of tantalum, tantalum oxide, tungsten and barium sulfate.
13. The composition according to claim 12 wherein said contrast agent is tantalum.
14. The composition according to claim 1 or claim 2 wherein said contrast agent is a water soluble contrast agent.
15. The composition according to claim 1 or claim 2 wherein said biocompatible polymer is a non-biodegradable, biocompatible polymer.
16. The composition according to claim 15 wherein said non-biodegradable, biocompatible polymer is selected from the group consisting of cellulose acetates, ethylene vinyl alcohol copolymers, hydrogels, polyacrylonitrile, polyvinylacetate, cellulose butyrate, nitrocellulose, copolymers of urethane/carbonate, copolymers of styrene/maleic acid, and mixtures thereof.
17. The composition according to claim 16 wherein said biocompatible polymer is an ethylene vinyl alcohol copolymer.