Method of treating depression with delta receptor agonist compounds
View Patent ↗Methods for treatment of depression or other affective mood disorders, such as bipolar manic depression or seasonal affective disorder, are disclosed by administration to a subject suffering or susceptible to same, of therapeutically effective diarylpiperazine compounds as herein described.
1. A method of combating depression in a subject experiencing or susceptible to same, comprising administering to said subject an effective amount of a therapeutic composition, wherein the composition comprises an active agent, wherein the active agent consists of at least one compound selected from the group consisting of:
where G=O-alkyl, N(alkyl) 2 , and any other pharmaceutically acceptable esters thereof;
and pharmaceutically acceptable salts and esters thereof.
2. A method of combating a mood disorder in a subject experiencing or susceptible to same, comprising administering to said subject an effective amount of a therapeutic composition comprising an active agent, wherein the active agent is at least one compound selected from the group consisting of:
and pharmaceutically acceptable salts and esters thereof, wherein said mood disorder comprises depression, bipolar manic depression or seasonal affective disorder.
3. A method of combating a mood disorder in a subject experiencing or susceptible to same, comprising administering to said subject an effective amount of a therapeutic composition comprising an active agent, wherein the active agent consists of at least one compound selected from the group consisting of:
where G=O-alkyl, N(alkyl) 2 , and any other pharmaceutically acceptable esters thereof;
and pharmaceutically acceptable salts and esters thereof, wherein the mood disorder comprises depression, bipolar manic depression or seasonal affective disorder.
4. The method of claim 3 , wherein said therapeutic composition is administered by an administration modality selected from the group consisting of oral, rectal, topical, sub-lingual, mucosal, nasal, ophthalmic, subcutaneous, intramuscular, intravenous, transdermal, spinal, intrathecal, intra-articular, intra-arterial, sub-arachnoid, bronchial, lymphatic, and intra-uterine administration.
5. A method for combating depression, bipolar manic depression or seasonal affective disorder in a subject experiencing or susceptible to same, comprising: affixing a patch to a corporeal locus containing a composition for combating depression, bipolar manic depression or seasonal affective disorder in a subject experiencing or susceptible to same, the composition comprising an active agent, wherein the active agent consists of a member selected from the group consisting of:
where G=O-alkyl, N(alkyl) 2 , and any other pharmaceutically acceptable esters thereof;
and pharmaceutically acceptable salts and esters thereof.
6. The method of claim 5 , wherein said patch comprises a transdermal patch.
7. The method of claim 5 , wherein said patch comprises a transmucosal patch.
8. A method of combating depression, bipolar manic depression or seasonal affective disorder in a subject experiencing or susceptible to same, comprising administering to said subject an effective amount of a therapeutic composition comprising an active agent, wherein the active agent consists of a diarylmethylpiperazine compound of the formula:
wherein:
Ar 1 is 6-member carbocyclic aromatic ring having on a carbon atom thereof a substituent Y, wherein Y is a carboxamide of the formula CONR 9 R 10 where R 9 and R 10 are both an ethyl group;
Z is selected from the group consisting of hydrogen, hydroxyl, and alkoxy; and
Ar 2 is a 6-member carbocyclic aromatic ring having on a carbon atom thereof a substituent X and wherein X is a halogen or hydrogen
or a pharmaceutically acceptable ester or salt thereof, wherein the mood disorder comprises depression, bipolar manic depression or seasonal affective disorder.