Modified cytokines for use in cancer therapy
View Patent ↗Cytokine derivatives capable of homing the tumoral vessels and the antigen presenting cells and the use thereof as antitumoral agents.
1. A cDNA encoding TNF bearing a 5′ or 3′ contiguous sequence encoding a peptide containing a NGR motif.
2. A cDNA according to claim 1 , wherein said NGR motif is selected from the group consisting of (SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11 and SEQ ID NO: 12.
3. A vector for gene therapy containing the cDNA of claim 1 or claim 2 operably linked to a control sequence that regulates the expression of said cDNA.
4. A pharmaceutical composition comprising an effective amount of the vector of claim 3 , together with pharmaceutically acceptable carriers and excipients.
5. A method of treating cancer comprising administering to a subject the cDNA of claim 1 or claim 2 operably linked to a control sequence that regulates the expression of said cDNA.
6. A pharmaceutical composition comprising an effective amount of the cDNA of claim 1 or 2 , together with pharmaceutically acceptable carriers and excipients, wherein said cDNA is operably linked to a control sequence that regulates the expression of the cDNA.