Polycyclic guanine derivative phosphodiesterase V inhibitors
View Patent ↗A compound having the formula (Ia) or (b), salt or solvate thereof, with the variables as defined herein, which can inhibit selectively phosphodiesterase V and can be useful for treating sexual dysfunction and other physiological disorders, symptoms and diseases:
1. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt or solvate thereof.
2. The compound according to claim 1 which is:
3. The compound according to claim 1 which is:
4. The compound according to claim 1 which is:
5. The compound according to claim 1 which is:
6. The compound according to claim 1 which is:
7. The compound according to claim 1 which is:
8. A pharmaceutical composition comprising the compound of claim 1 or a salt or solvate thereof and a pharmaceutically acceptable carrier.
9. The composition according to claim 8 , wherein the compound of claim 1 , salt or solvate thereof is administered to a patient in an amount ranging from about 1 to about 1000 milligrams per day.
10. The compound according to claim 1 which is:
11. The compound according to claim 1 which is:
12. The compound according to claim 1 which is:
13. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt or solvate thereof.
14. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt or solvate thereof.