Uninterrupted flow pump apparatus and method
View Patent ↗This invention describes a method for pumping or delivering fluids utilizing a flexible vessel subject to controlled pressures within another pressure vessel. The pressure vessel can be sourced with positive and/or negative (e.g., vacuum) pressure.
1. An apparatus for providing substantially stable flow of a biological fluid comprising:
an outer chamber adapted to contain a sealed flexible chamber, wherein said outer chamber is adapted to provide a space containing a pressure sensitive medium around said sealed flexible chamber;
said sealed flexible chamber adapted to contain fluid, wherein said sealed flexible chamber comprises a fluid path between said sealed flexible chamber and an exterior of said outer chamber;
a receiving container that is in fluid communication with said sealed flexible chamber via a photoactivation element, and is adapted for returning said fluid from said receiving container to said sealed flexible chamber;
a pressure reservoir adapted for continuously increasing or decreasing the pressure in a uniform and controlled manner within said space around said sealed flexible chamber;
a pressure valve adapted for continuously increasing or decreasing the pressure in a uniform and controlled manner within said space around said sealed flexible chamber, wherein said apparatus renders said biological fluid suitable for return to a patient; and
means for monitoring the properties of fluid displaced into or out of said sealed flexible chamber, wherein said means for monitoring comprises a load cell.
2. An apparatus for providing substantially stable flow of a biological fluid comprising:
a sealed flexible chamber adapted to contain fluid disposed within an outer chamber, wherein said sealed flexible chamber comprises a fluid path between said sealed flexible chamber and the exterior of said outer chamber and wherein said outer chamber is adapted to provide a space containing a pressure sensitive medium around said sealed flexible chamber;
means for continuously increasing or decreasing the pressure in a uniform and controlled manner within said space around said sealed flexible chamber;
means for changing the pressure within said space around said sealed flexible chamber such that fluid is displaced into or out of said sealed flexible chamber in a uniform and controlled manner, wherein said apparatus renders said biological fluid suitable for return to a patient; and
a receiving container that is in fluid communication with said sealed flexible chamber via a photoactivation element, and is adapted for returning said fluid from said receiving container to said sealed flexible chamber;
wherein said apparatus is adapted for use in conjunction with a photopheresis process that comprises collecting a buffy-coat fraction of said biological fluid; adding a photoactivatable drug to said buffy-coat fraction; exposing said buffy-coat fraction to light energy; and reinfusing said exposed buffy-coat fraction.
3. The apparatus of claim 2 , wherein said buffy-coat fraction comprises white blood cells.
4. The apparatus of claim 2 , wherein said photoactivatable drug is 8-methoxyp-soralen.
5. The apparatus of claim 2 , wherein said light energy comprises ultraviolet A.