IP Library › Granted Patent US 6,919,185
Granted Patent B2
US 6,919,185 · App. 10/296,144 · Granted Jul 19, 2005

Regulation of human transketolase-like enzyme

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Quick Facts
Patent No.
US 6,919,185
App. No.
10/296,144
Granted
Jul 19, 2005
Kind
B2
Abstract

Reagents which regulate human transketolase-like enzyme and reagents which bind to human transketolase-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, anemia, and end-stage renal disease, including sensory periphery neuropathy associated with uremia.

Claims (6)

1. A method of screening for candidate modulators of transketolase activity comprising the steps of:

contacting a protein comprising the amino acid sequence shown in SEQ ID NO:2 with a test compound;

assaying for binding between the protein and the test compound; and

identifying a test compound that binds to the protein as a candidate modulator of transketolase activity that may be useful for regulating activity of the protein.

2. The method of claim 1 wherein either the test compound or the protein comprises a detectable label.

3. The method of claim 1 wherein either the test compound or the protein is bound to a solid support.