Conjugates comprising two active agents
View Patent ↗The present invention pertains to a pharmaceutical conjugate comprising an insoluble carrier to which first and second active agents are bound, respectively via a first linker to a first functional group on the carrier and via a second linker to a second functional group on the carrier. For example, fibrinogen and Factor VIII can be independently linked to albumin microcapsules.
1. A pharmaceutical conjugate comprising an insoluble carrier to which first and second active agents are bound, respectively via a first linker to a first functional group on the carrier and via a second linker to a second functional group on the carrier, wherein one of the agents is effective to treat said bleeding condition or tumor and the other agent acts as a targeting agent to the site; and wherein the carrier is an insolubilized protein and the functional groups are selected from the group consisting of SH, NH 2 and COOH; and wherein one of the agents is a glycoprotein.
2. The conjugate according to claim 1 , wherein the carrier is insolubilized human serum albumin.
3. The conjugate according to claim 1 , wherein the carrier is in the form of microcapsules.
4. The conjugate according to claim 1 , wherein the first agent is Factor VIII.
5. The conjugate according to claim 1 , wherein the second agent is fibrinogen.
6. The conjugate according to claim 1 , wherein the first linker is at least 10 nm long.
7. The conjugate according to claim 1 , wherein the first linker is a dihydrazide reagent.